Fabrication of acetylated dioscorea starch nanoparticles: Optimization of formulation and process variables

Paulos, Getahun; Mrestani, Yahya; Heyroth, Frank; Gebre‐Mariam, Tsige; Neubert, Reinhard H.H.

doi:10.1016/j.jddst.2015.11.009

Cited by 22 publications

(6 citation statements)

References 34 publications

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“…It is observed that a new peak absorption band appeared at 1727 cm −1 , and it was attributed to the stretching of the ester carbonyl CO, which indicated the acetylation of starch. [ 28 ] It was noticed from Figure 2C that with increasing moisture content, the peak at 1727 cm −1 rose significantly and decreased gradually. The results also proved the vital function of water in the acetylation of starch.…”

Section: Resultsmentioning

confidence: 99%

Influence of Moisture Content on Starch Esterification by Solvent‐Free Method

Zhu¹,

Lu²,

Liu³

et al. 2021

Starch Stärke

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Moisture is of vital importance in starch modification; however, the molecular interaction between water and starch during the process is far from being fully understood. In this study, two fundamental issues of starch esterification by the solvent‐free method are focused on: 1) the effect of moisture content of starch on the modification and 2) the effect of the physical state, solid or liquid, of chemical agents. The esterification of corn starch with varying contents of moisture (2.69–23.48 wt%) is investigated by the solvent‐free method, using both solid (maleic anhydride and maleic acid) and liquid (acetic anhydride and acetic acid) esterifying agents for comparison. The degree of substitution (DS) and reaction efficiency (RE) is measured by titration. FTIR, 1H NMR, DSC, XRD, and SEM are used to evaluate the properties of the modified starches. It is found that when the moisture content is below 5.55 wt%, it is hard for esterification to happen because of strong interactions between H‐bonds and the low activity of hydroxyl groups. Both DS and RE reached the maximum points when the moisture is ≈14.89 wt%, then decreased with further increasing moisture content, mainly due to side reaction and dilution of the esterifying agents.

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Section: Resultsmentioning

confidence: 99%

Influence of Moisture Content on Starch Esterification by Solvent‐Free Method

Zhu¹,

Lu²,

Liu³

et al. 2021

Starch Stärke

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“…H ydrophilic matrix systems are most popular because of the simplicity of formulation, ease of manufacturing, low cost, Food and Drug Administration acceptance, and applicability to drugs with a wide range of solubility. [1][2][3][4][5] Drug release from these systems is the sequence of controlled matrix hydration, followed by gel formation, change of textural/ rheological behavior, matrix erosion, and/or drug dissolution and diffusion, the significance of which depends on drug solubility, concentration, and changes in matrix characteristics. [6] Statistical experimental design methodologies are powerful, efficient, and systematic tools in the design of pharmaceutical dosage forms, allowing a rational study of the influence of formulation parameters on the selected responses with a shortening of the experiment time and an improvement in the research and development work.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Sharma¹

2020

AJP

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Aim: Natural materials have advantages over synthetic materials as pharmaceuticals because they are nontoxic, less expensive, and easily available. Furthermore, they can be modified to obtain customized materials for drug delivery systems better or equivalent to synthetic products that are commercially available. The present investigation aimed at the optimization of controlled release hydrogel microsphere of metformin hydrochloride prepared with bora rice flour (BRF), mucilage of Dillenia indica fruits, and mucilage of Abelmoschus esculentus in combination. Materials and Methods: Physical, mucoadhesive, and in vitro drug release properties were studied. Validation of the optimization process, selection of optimized batch, and stability study of optimized batch were also among the objectives of this study. The response surface approach was used for optimization process. The experimental values were compared with the predicted values, and percentage errors were calculated. Results and Discussion: In the statistical optimization process, the models for the selected response variables were significant. It was observed that there was variable influence of the concentration of the independent variables (BRF and mucilage) on the responses. Mucilage exhibited pronounced effect on the properties of microspheres than BRF. However, the observed effect was the resultant effect of the influence of individual variables on microspheres. Conclusion: In this study, much deviation was not of the experimental values from the predicted values.

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“…It is also the second most abundant biomass material in nature . Due to its natural abundance, biocompatibility, and relatively easy structural modification through physical, enzymatic, and chemical methods, starch products and starch derivates have been used widely in the food, cosmetic, and pharmaceutical industries . In recent years, much interest has emerged in the use of starch‐based nanomaterials, either as reinforced composite materials or as bioactive molecule carriers .…”

Section: Introductionmentioning

confidence: 99%

“…1 Due to its natural abundance, biocompatibility, and relatively easy structural modification through physical, enzymatic, and chemical methods, starch products and starch derivates have been used widely in the food, cosmetic, and pharmaceutical industries. 2 In recent years, much interest has emerged in the use of starch-based nanomaterials, either as reinforced composite materials or as bioactive molecule carriers. [3][4][5][6][7] In brief, starch nanomaterials are nano-size particles obtained either by acid hydrolysis or through controlled precipitation by using different mechanical or chemical methods.…”

Section: Introductionmentioning

confidence: 99%

Citric‐acid modified banana starch nanoparticles as a novel vehicle for β‐carotene delivery

2019

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BACKGROUND Starch nanoparticles have become among the most interesting nanovehicles for drug delivery because of their relatively easy synthesis, biocompatibility, and numerous botanical sources. Starch nanoparticles obtained from green bananas were cross‐linked with citric acid and loaded with β‐carotene. RESULTS Mean particle size, encapsulation efficiency, and β‐carotene release in simulated gastric and intestinal fluids and food simulants were studied. Cross‐linked nanoparticles showed higher loading efficiency and encapsulation capacity, indicating that they can accommodate more molecules than their unmodified counterparts, while mathematical models showed a diffusion of released β‐carotene into food simulant media. CONCLUSIONS Cross‐linked nanoparticles showed more controlled release under gastric conditions, mainly in the simulated intestinal fluid, indicating that they are suitable as vehicles for intestine‐specific targeting. This controlled released was also observed in food simulants, with lower release values in the more aqueous simulants. © 2019 Society of Chemical Industry

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Fabrication of acetylated dioscorea starch nanoparticles: Optimization of formulation and process variables

Cited by 22 publications

References 34 publications

Influence of Moisture Content on Starch Esterification by Solvent‐Free Method

Influence of Moisture Content on Starch Esterification by Solvent‐Free Method

Untitled

Citric‐acid modified banana starch nanoparticles as a novel vehicle for β‐carotene delivery

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