Abstract:Aim: Natural materials have advantages over synthetic materials as pharmaceuticals because they are nontoxic, less expensive, and easily available. Furthermore, they can be modified to obtain customized materials for drug delivery systems better or equivalent to synthetic products that are commercially available. The present investigation aimed at the optimization of controlled release hydrogel microsphere of metformin hydrochloride prepared with bora rice flour (BRF), mucilage of Dillenia indica fruits, and m… Show more
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