Fabrication of a Zn(II)‐Based 2D Pillar Bilayer Metal‐Organic Framework for Antimicrobial Activity

Dutta, Basudeb; Pal, Kunal; Jana, Kuladip; Sinha, Chittaranjan; Mir, Mohammad Hedayetullah

doi:10.1002/slct.201901887

Cited by 16 publications

(8 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Distinctive physicochemical properties of the MOF enhance the loading capacity of the MOF compared to other carrier molecules. , Lipophilic outer membranes of bacteria only allow hydrophobic and amphiphilic plant metabolites to be internalized and employ their antimicrobial action. The phytochemical-loaded MOF showed greater antimicrobial action. − Thus, it can be a potential carrier of the hydrophobic metabolites to control pathogenic species.…”

Section: Potential Of Mof Against Resistant Microbesmentioning

confidence: 99%

“…MOFs have been used extensively as biomolecules and drug carrier molecules in recent years. , Hence, MOF-mediated antibiotics (e.g., ciprofloxacin, gentamicin, vancomycin, nalidixic acid, gentamicin, and vancomycin) delivery can be a potential tool to treat microbial infection. , Loading of antibiotics does not affect the crystal phase of the framework and thus maintains its properties . Therefore, a synergistic effect of the MOF with antibiotics and other antimicrobial agents is another effective way to control resistant microorganisms.…”

Section: Potential Of Mof Against Resistant Microbesmentioning

confidence: 99%

“…Therefore, a synergistic effect of the MOF with antibiotics and other antimicrobial agents is another effective way to control resistant microorganisms. Here, the MOF induces membrane permeability and allows a sufficient amount of antibiotics to be internalized and inhibit MDR bacterial growth. − In a comprehensive study, ampicillin and kanamycin were loaded into three Zn-based MOFs (i.e., IRMOF-3, MOF-5, and Zn-BTC) and observed a decline in MIC values in all of the antibiotic-loaded MOFs compared to the free antibiotics . Moreover, antimicrobial activity of physcion or dihydroxyanthraquinone was enhanced after being encapsulated by ZIF-8 .…”

Section: Potential Of Mof Against Resistant Microbesmentioning

confidence: 99%

See 2 more Smart Citations

Prospects of Exploring the Metal–Organic Framework for Combating Antimicrobial Resistance

Polash

Khare

Kumar

et al. 2021

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Infectious diseases are a major public health concern globally. Infections caused by pathogens with resistance against commonly used antimicrobial drugs or antibiotics (known as antimicrobial resistance, AMR) are becoming extremely difficult to control. AMR has thus been declared as one of the top 10 global public health threats, as it has very limited solutions. The drying pipeline of effective antibiotics has further worsened the situation. There is no absolute treatment, and the limitations of existing methods warrant further development in antimicrobials. Recent developments in the nanomaterial field present them as promising therapeutics and effective alternative to conventional antibiotics and synthetic drugs. The metal–organic framework (MOF) is a recent addition to the antimicrobial category with superior properties. The MOF exerts antimicrobial action on a wide range of species and is highly biocompatible. Additionally, their porous structures allow the incorporation of biomolecules and drugs for synergistic antimicrobial action. This review provides an inclusive summary of the molecular events responsible for resistance development and current trends in antimicrobials to combat antibiotic resistance and explores the potential role of the MOF in tackling the drug-resistant microbial species.

show abstract

Section: Potential Of Mof Against Resistant Microbesmentioning

confidence: 99%

Section: Potential Of Mof Against Resistant Microbesmentioning

confidence: 99%

Section: Potential Of Mof Against Resistant Microbesmentioning

confidence: 99%

See 1 more Smart Citation

Prospects of Exploring the Metal–Organic Framework for Combating Antimicrobial Resistance

Polash

Khare

Kumar

et al. 2021

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…In the 2D MOF [Zn 2 (aip) 2 (bpy)(H 2 O) 2 ]•2MeOH (aip = 5-aminoisophthalate), the square pyramidal Zn(II) atom is bonded to an aqua ligand, an oxygen atom of aip, an N atom of the amino group, and a N from bpy in the equatorial basal plane. 416 The oxygen atom of another aip anion occupies the apical position. The aip anion in turn connected three different Zn(II) atoms.…”

mentioning

confidence: 99%

Two-Dimensional Metal-Organic Framework Materials: Synthesis, Structures, Properties and Applications

et al. 2021

View full text Add to dashboard Cite

Among the recent developments in metal-organic frameworks (MOFs), porous layered coordination polymers (CPs) have garnered attention due to their modular nature and tunable structures. These factors enable a number of properties and applications, including gas and guest sorption, storage and separation of gases and small molecules, catalysis, luminescence, sensing, magnetism, and energy storage and conversion. Among MOFs, two-dimensional (2D) compounds are also known as 2D CPs or 2D MOFs. Since the discovery of graphene in 2004, 2D materials have also been widely studied. Several 2D MOFs are suitable for exfoliation as ultrathin nanosheets similar to graphene and other 2D materials, making these layered structures useful and unique for various technological applications. Furthermore, these layered structures have fascinating topological networks and entanglements. This review provides an overview of different aspects of 2D MOF layered architectures such as topology, interpenetration, structural transformations, properties, and applications.

show abstract

“…This work significantly unlocks a new path of application of MOF-embedded hydrogels in treating skin diseases and drug delivery. A Zn(II) based 2D MOF [{Zn(aip)(4,4′bpy) 0.5 (MeOH)}•(H 2 O)] n (H 2 aip = 5-aminoisophthalic acid and 4,4′-bpy = 4,4′-bipyridine) was reported by Dutta et al119 The compound exhibited antibacterial action on E. coli and S. aureus with IC50 values of 86.26 ± 1.2 and 95.96 ± 2.04 μg mL , respectively. Lee and co-workers reported zeolite based framework ZIF-8 loaded with iodine.…”

mentioning

confidence: 99%

Smart Metal–Organic Frameworks for Biotechnological Applications: A Mini-Review

Chattopadhyay

Mandal

Maiti

2021

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

In this pandemic situation it is evident that viruses and bacteria, more specifically, multiple drug resistant (MDR) bacteria, endanger human civilization severely. It is high time to design smart weapons to combat these pathogens for the prevention and cure of allied ailments. Metal–organic frameworks (MOFs) are porous materials designed from metal ions or inorganic clusters and multidentate organic ligands. Due to some unique features like high porosity, tunable pore shape and size, numerous possible metal-ligand combinations, etc., MOFs are ideal candidates to design “smart biotechnological tools”. MOFs construct promising fluorescence based biosensing platforms for detection of viruses. MOFs also exhibit excellent antibacterial activity due to their ability for sustained release of active biocidal agents. There are several reviews that summarize the antibacterial applications of MOFs, but the biosensing platforms based on MOFs for detection of viruses have scarcely been summarized. This review carefully covers both the aspects including virus detection (nucleic acid recognition and immunological detection) with underlying mechanisms as well as antibacterial application of MOFs and doped MOFs or composites. This review will deliver valuable information and references for designing new, smarter antimicrobial agents based on MOFs.

show abstract

Fabrication of a Zn(II)‐Based 2D Pillar Bilayer Metal‐Organic Framework for Antimicrobial Activity

Cited by 16 publications

References 53 publications

Prospects of Exploring the Metal–Organic Framework for Combating Antimicrobial Resistance

Prospects of Exploring the Metal–Organic Framework for Combating Antimicrobial Resistance

Two-Dimensional Metal-Organic Framework Materials: Synthesis, Structures, Properties and Applications

Smart Metal–Organic Frameworks for Biotechnological Applications: A Mini-Review

Contact Info

Product

Resources

About