Fabrication of a Retinal‐protein Photoreceptor Array

Zhao, Yingchun; Jia, Wang; Huang, Weida; Ding, Jiandong

doi:10.1002/cjoc.201100252

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…Here we introduced chromium between glass and gold, because an integrating layer of chromium is helpful for avoiding the detachment of gold off glass. 47 It was also conrmed in this study (data not shown).…”

Section: Preparation and Observation Of Hap Micropatternssupporting

confidence: 51%

Preparation of hydroxyapatite micropatterns for the study of cell–biomaterial interactions

Wang

Chen

et al. 2014

J. Mater. Chem. B

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Section: Preparation and Observation Of Hap Micropatternssupporting

confidence: 51%

Preparation of hydroxyapatite micropatterns for the study of cell–biomaterial interactions

Wang

Chen

et al. 2014

J. Mater. Chem. B

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“…For instance, retinal proteins such as bacteriorhodopsin (BR)273–280 and archaerhodopsin281–283 are classic families of photoresponsive biomacromolecules, and BR has recently been found to serve as a non‐fouling chemical 284, 285. A corresponding BR array has even been prepared, which remains the light‐driven proton‐pumping activity 286. How to use those responsive chemicals as the background of cell patterns might be a topic of functional patterns in the future.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Cell–Material Interactions Revealed Via Material Techniques of Surface Patterning

2013

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Cell-material interactions constitute a key fundamental topic in biomaterials study. Various cell cues and matrix cues as well as soluble factors regulate cell behaviors on materials. These factors are coupled with each other as usual, and thus it is very difficult to unambiguously elucidate the role of each regulator. The recently developed material techniques of surface patterning afford unique ways to reveal the underlying science. This paper reviews the pertinent material techniques to fabricate patterns of microscale and nanoscale resolutions, and corresponding cell studies. Some issues are emphasized, such as cell localization on patterned surfaces of chemical contrast, and effects of cell shape, cell size, cell-cell contact, and seeding density on differentiation of stem cells. Material cues to regulate cell adhesion, cell differentiation and other cell events are further summed up. Effects of some physical properties, such as surface topography and matrix stiffness, on cell behaviors are also discussed; nanoscaled features of substrate surfaces to regulate cell fate are summarized as well. The pertinent work sheds new insight into the cell-material interactions, and is stimulating for biomaterial design in regenerative medicine, tissue engineering, and high-throughput detection, diagnosis, and drug screening.

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“…The inner and outer segments of the retinal photoreceptors are the areas that receive light signals and are the most initial sites for generating visual impulses, and the integrity of the IS/OS directly affects visual sensitivity. [2] Thus IS/OS fracture can lead to significant vision loss. [3] A retrospective, comparative, consecutive case study from the Department of Ophthalmology at the University of California, San Diego included 62 eyes of 38 patients with diabetic macular edema undergoing SD-OCT imaging and showed a significant correlation between the percentage of disruption of the photoreceptor inner-segment-outer-segment connection and visual acuity in diabetic macular edema ( P = .0312).…”

Section: Lessons Subsectionsmentioning

confidence: 99%

Visual training for the treatment of retinal photoreceptor inner and outer segment connection (IS/OS) fracture: A case report

Jiang,

Xu,

Chen

et al. 2024

Medicine

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Background: The inner segments and outer segments (IS/OS) of the retinal photoreceptors are the areas that receive light signals and are the most initial sites for generating visual impulses, and the integrity of the IS/OS has a direct impact on visual sensitivity. Methods: We performed OCT on a 6-year-old child with vision loss and found that the cause of his vision loss was a retinal IS/OS fracture, and the child underwent some treatments to improve microcirculation and nourish the retina at a higher-level hospital, but his vision never improved. Our examination of this child revealed that this child not only had decreased visual acuity, but also hypermetropia, but his near stereopsis was normal. The symptoms were similar to those of amblyopia, so we tried to use visual training as a treatment. Results: First, 6 sessions of fine visual stimulation were given, followed by 3 sessions of accommodation training, and we followed the 4 stages of accommodation training: perception of accommodation, amplitude of accommodation, sensitivity of accommodation, and autonomic accommodation. After 9 consecutive visual training sessions, the child’s visual acuity was stabilized at 0.6, and then we added eye movement training, and after the child’s visual acuity was improved to 0.7, we suppressed the visual acuity of the left eye to 0.6, so as to make the visual acuity of both eyes similar, which would promote the establishment of binocular stereo vision, and then we carried out 9 more visual training sessions, and the patient’s visual acuity was stabilized at 0.8 gradually. OCT review showed that the child’s retinal IS/OS fracture was basically closed. Conclusion subsections: In conclusion, our study found that visual training can restore visual acuity in children with monocular IS/OS fracture and also promote repair of IS/OS fracture, which increases our understanding and knowledge of the treatment of retinal IS/OS fracture, and this case may provide some lessons for the treatment of retinal IS/OS fracture in children. We hope to have more samples of retinal IS/OS fracture in the future to evaluate the efficacy of visual training for retinal IS/OS fracture.

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Fabrication of a Retinal‐protein Photoreceptor Array

Cited by 7 publications

References 37 publications

Preparation of hydroxyapatite micropatterns for the study of cell–biomaterial interactions

Preparation of hydroxyapatite micropatterns for the study of cell–biomaterial interactions

Cell–Material Interactions Revealed Via Material Techniques of Surface Patterning

Visual training for the treatment of retinal photoreceptor inner and outer segment connection (IS/OS) fracture: A case report

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