Fabrication of a molecularly imprinted silylated graphene oxide polymer for sensing and quantification of creatinine in blood and urine samples

Anirudhan, T.S.; Deepa, J.; Stanly, Nisha

doi:10.1016/j.apsusc.2018.10.001

Cited by 35 publications

(15 citation statements)

References 47 publications

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“… 49 The DPV technique was used to detect creatinine using a molecular imprinting sensor consist of silver nanoparticles and reduced graphene oxide functionalized with polyoxometalate, obtaining a limit of detection of 0.0151 nM. 50 Among the lowest limits of detection obtained by DPV are 76.3 nM, 51 0.61 mg dL −1 μM −1 52 and 43 μM. 53 …”

Section: Electrochemical Techniques For Detection and Characterizationmentioning

confidence: 99%

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Electrochemical creatinine detection for advanced point-of-care sensing devices: a review

et al. 2022

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Section: Electrochemical Techniques For Detection and Characterizationmentioning

confidence: 99%

“… 43 Anirudhan et al fabricated a new molecularly imprinted polymer based on a TMSPMA–GO- co -HEMA/MMA composite, with a limit of detection of 16.6 μM and a concentration range of 44.2–265.21 μM. 52 TMSPMA interacts with GO through its OH groups, forming the Si–O–C bond.…”

Section: Nanomaterials In Creatinine Electrochemical Sensors (Ces)mentioning

confidence: 99%

Electrochemical creatinine detection for advanced point-of-care sensing devices: a review

et al. 2022

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“…This method provides the advantages of higher bonding capacity and faster bonding kinetics on the material surface [136]. The applications of MIPs combined with electrochemical studies have increased in the sensor field because of their ease of use and low cost [137]. However, some problems still need to be overcome before MIP-based sensors can enter the sensor market.…”

Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Laraib

Arshad

et al. 2021

Nanomaterials

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Over various scientific fields in biochemistry, amino acids have been highlighted in research works. Protein, peptide- and amino acid-based drug delivery systems have proficiently transformed nanotechnology via immense flexibility in their features for attaching various drug molecules and biodegradable polymers. In this regard, novel nanostructures including carbon nanotubes, electrospun carbon nanofibers, gold nanoislands, and metal-based nanoparticles have been introduced as nanosensors for accurate detection of these organic compounds. These nanostructures can bind the biological receptor to the sensor surface and increase the surface area of the working electrode, significantly enhancing the biosensor performance. Interestingly, protein-based nanocarriers have also emerged as useful drug and gene delivery platforms. This is important since, despite recent advancements, there are still biological barriers and other obstacles limiting gene and drug delivery efficacy. Currently available strategies for gene therapy are not cost-effective, and they do not deliver the genetic cargo effectively to target sites. With rapid advancements in nanotechnology, novel gene delivery systems are introduced as nonviral vectors such as protein, peptide, and amino acid-based nanostructures. These nano-based delivery platforms can be tailored into functional transformation using proteins and peptides ligands based nanocarriers, usually overexpressed in the specified diseases. The purpose of this review is to shed light on traditional and nanotechnology-based methods to detect amino acids, peptides, and proteins. Furthermore, new insights into the potential of amino protein-based nanoassemblies for targeted drug delivery or gene transfer are presented.

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“…Synthetic MIPs with different polymers have been used as extraction sorbents of carbamazepine in various matrices, e.g., urine [26,27], blood [28], and environmental waters [29]. Moreover, MIPs have also been reported for the extraction of other analytes, e.g., atenolol [30], creatinine [31], cortisol [32], and myoglobin [33] from blood samples.…”

Section: Introductionmentioning

confidence: 99%

Paper-based molecularly imprinted-interpenetrating polymer network for on-spot collection and microextraction of dried blood spots for capillary electrophoresis determination of carbamazepine

2020

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Carbamazepine is an antiepileptic drug with a narrow therapeutic index, which requires an efficient method for blood level monitoring. Finger-prick dried blood spot (DBS) collection is an alternative microsampling technique, which is less invasive than conventional venipuncture. Paper-based molecularly imprinted-interpenetrating polymer networks (MI-IPN) were developed as blood collection devices, which allowed for selective on-spot microextraction of carbamazepine from DBS. A hybrid of homogeneous polystyrene and silica gel polymer was synthesized and coated on a Whatman ® Grade 1 filter paper. Proteins and other interferences in the blood samples were eliminated by using the MI-IPN collection devices, and the resulting DBS extracts were suitable for direct injection into the capillary electrophoretic instrument. The lower limit of quantitation of 4 μg/mL in capillary blood was achieved by the sweeping-micellar electrokinetic chromatography method using a KCl-containing matrix, which was sufficient for the therapeutic drug monitoring purposes. Method accuracies were in the range of 88.4 ± 4.5% to 94.5 ± 2.7% with RSD values ≤ 5.1%. The developed paper-based MI-IPN provided superior extraction efficiencies (92.2 ± 2.5%) in comparison with commercially available DBS collection cards, i.e., Whatman ® 903 protein saver card (59.8 ± 2.8%) and GenCollect™ 2.0 card (47.2 ± 1.4%). The paper-based MI-IPN devices for DBS collection and on-spot extraction were characterized by simple fabrication, low costs, disposability, and reduction in sample preparation steps, and their further developments might open new perspectives in clinical applications, such as in therapeutic drug monitoring.

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Fabrication of a molecularly imprinted silylated graphene oxide polymer for sensing and quantification of creatinine in blood and urine samples

Cited by 35 publications

References 47 publications

Electrochemical creatinine detection for advanced point-of-care sensing devices: a review

Electrochemical creatinine detection for advanced point-of-care sensing devices: a review

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Paper-based molecularly imprinted-interpenetrating polymer network for on-spot collection and microextraction of dried blood spots for capillary electrophoresis determination of carbamazepine

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