Fabrication, modification, and application of poly(methyl methacrylate) microfluidic chips

Chen, Yun; Zhang, Luyan; Chen, Gang

doi:10.1002/elps.200700552

Cited by 150 publications

(93 citation statements)

References 123 publications

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“…Polymeric materials can be divided into two main groups: elastomers (including for example, PDMS [20] and polyurethane [21]) and thermoplastics (comprising polycarbonate and PMMA). Due to its high mechanic and chemical stability, optical transparency, and excellent dielectric properties [22], PMMA has become one of the most popular substrates for ME systems. These properties have also allowed for the development of different fabrication methods including hot embossing [23], injection molding [24], and laser engraving [25,26].…”

Section: Introductionmentioning

confidence: 99%

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Gabriel,

Coltro,

Garcia

2014

Electrophoresis

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This paper describes the effects of different modes and engraving parameters on the dimensions of microfluidic structures produced in PMMA using laser engraving. The engraving modes included raster and vector while the explored engraving parameters included power, speed, frequency, resolution, line-width and number of passes. Under the optimum conditions, the technique was applied to produce channels suitable for CE separations. Taking advantage of the possibility to cut-through the substrates, the laser was also used to define solution reservoirs (buffer, sample, and waste) and a PDMS-based decoupler. The final device was used to perform the analysis of a model mixture of phenolic compounds within 200 s with baseline resolution.

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Section: Introductionmentioning

confidence: 99%

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Gabriel,

Coltro,

Garcia

2014

Electrophoresis

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“…The PMMA microspheres used in this study exhibited ideal characteristics in terms of inertness, stability at room temperature, availability, low production cost, physical consistency at the implantation site similar to that of un implanted tissue, and durability [7][8][9][10][11][12]18,19,28,29].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have shown that polymethylmethacrylate (PMMA) is biocompatible, does not generate an inflammatory response when implanted under the skin, and remains at the implantation site for long periods [11,18,19]. Because of its small number of side effects and its lasting results, PMMA is believed to be a good solution for dermal filling.…”

Section: Introductionmentioning

confidence: 99%

Potential of Migration and Tissue Reactions to Intraperitoneally Implanted Polymethyl Methacrylate in Wistar Rats

Fc¹,

Acl²,

A³

2016

J Clin Exp Dermatol Res

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Objective: This study aimed to evaluate the performance of polymethyl methacrylate (PMMA) when implanted into the peritoneal cavities of Wistar rats, specifically its potential for migration to the examined organs and possible tissue reactions at the implantation site.Methods: Adult male Wistar rats (290-400 g) were distributed randomly into 2 groups: P4 (n=20), to which 0.4 mL of PMMA was administered; and P2 (n= 0), to which was 2 mL of PMMA were administered. These groups were subsequently divided into 4 subgroups according to the day on which euthanasia occurred (day 1, 7, 14, or 28). Results:The changes in animal weight prior to PMMA implantation and after euthanasia were compared. No nodules or signs of PMMA implantation or any other macroscopic alterations were observed in the spleen, kidneys, lungs, or liver. However, mild-to-moderate inflammatory infiltration in which macrophages, lymphocytes, and neutrophils predominated was observed in at least 1 of the 4 organs examined from each animal during the experimental time points. Mild inflammatory responses were observed that were rich in histiocytes and giant cells and featured increased numbers of blood vessels and fibroblasts in the pericapsular regions of the studied organs. In 29 cases, a greyish material compatible with PMMA was identified. There was no migration of PMMA into the parenchyma of the examined organs. The changes in the tissues were the same regardless of the volume of implanted PMMA. Following staining with HE, the PMMA particles in the tissues were a grayish color, measuring approximately 30-40 µm in size, and were found to have stimulated histiocytic reactions in 29 examined organs. Conclusions:The results showed that the most affected tissues were the visceral peritoneum of the spleen and the kidneys from group P2. Our study may contribute to add a new proof of testing implants.

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“…PMMA, used for fabricating the main modules of the system, has low hydrophobicity and can be easily modified. 29 Most importantly, it is sufficiently UV permeable to allow the hapten immobilization. Elasticity of PDMS 30 has been instrumental in achieving the functionality of the ribbons used in the micropump and valves as well as leakage-proof sealing to flat surfaces using the BJIB module-to-module interconnections.…”

Section: Fabrication Of µFia Based Amperometric Immunosensormentioning

confidence: 99%

Micro-flow-injection analysis (μFIA) immunoassay of herbicide residue 2,6-dichlorobenzamide – towards automated at-line monitoring using modular microfluidics

Uthuppu

Heiskanen

Kofoed

et al. 2015

Analyst

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Fabrication, modification, and application of poly(methyl methacrylate) microfluidic chips

Cited by 150 publications

References 123 publications

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving

Potential of Migration and Tissue Reactions to Intraperitoneally Implanted Polymethyl Methacrylate in Wistar Rats

Micro-flow-injection analysis (μFIA) immunoassay of herbicide residue 2,6-dichlorobenzamide – towards automated at-line monitoring using modular microfluidics

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