Fabrication, Characterization and Electrochemical Modeling of CNT Based Enzyme Field Effect Acetylcholine Biosensor

Dutta, Jiten Chandra; Sharma, Purnima Kumari

doi:10.1109/jsen.2018.2810133

Cited by 22 publications

(11 citation statements)

References 39 publications

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“…This dependence is nonmonotonic, and the CNTs can have distinct band gap energies which principally determine the behavior and type of the CNTs as either metallic or semiconducting. Semiconducting CNT is sensitive to its environment and varies significantly with surface adsorption of various chemicals and biomolecules and hence able to detect various biological species such as DNA, proteins, antibodies, living cells and single molecules [22], [23]. Typical CNTFET with top gate and back gate structure is illustrated in Fig.…”

Section: Cnt As Biofet Sensing Channelmentioning

confidence: 99%

“…Moreover, high-k materials can achieve quite same capacitance with small thickness compared to bulkier low-k materials. Indeed, the integration of high-k dielectric materials with CNTs is the way forward for device miniaturization as they exhibit superior performance in terms of subthreshold swings, high transconductance and mobility at the sub-microscale [23].…”

Section: A Cnt Channel Morphologymentioning

confidence: 99%

“…This immunosensor reportedly had a limit of detection 1.37 pg/mL. Sharma and Dutta (2018) developed a CNT based enzyme filed effect transistor biosensor on ITO coated glass substrate passivated by a thin insulating layer of intrinsic ZnO for acetylcholine (Ach) detection [23]. Quasi-ohmic contact between the Al source and drain and the CNT channel was observed as the work function of Al is less than CNT.…”

Section: Recent Studies On Cnt-biofetsmentioning

confidence: 99%

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A Review of Carbon Nanotubes Field Effect-Based Biosensors

et al. 2020

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Field effect-based biosensors (BioFETs) stand out among other biosensing technologies due to their unique features such as real time screening, ultrasensitive detection, low cost, and amenability to extreme device miniaturization due to the convenient utilization of nanoscale materials. Nanodevices pave the way for the detection of tiny biomolecules and minute concentrations of analytes as they are ultrasensitive to surface charge modulation, allowing for better point-of-care screening of various life-threatening infectious diseases. Semiconducting carbon nanotubes (sc-CNTs) are exceptionally promising for FET-channel integration to replace bulky silicon technology beyond the dimensions of the short channel effects for their 1D ultrathin structure, superior electronic features, and biocompatibility. However, performance of CNTFET biosensors is influenced by the inhomogeneous interface between sc-CNTs and metallic source and drain electrodes. This article reviews recent studies on CNTFET biosensors, morphology of these devices and the cause-and-effect of the interface issues between sc-CNTs and metallic electrodes. Finally, future outlook on suggested technology to improve the performance of such CNTFET devices is presented. INDEX TERMS BioFETs, biomolecules, biosensors, carbon nanotubes, contact resistance, metal electrodes.

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Section: Cnt As Biofet Sensing Channelmentioning

confidence: 99%

Section: A Cnt Channel Morphologymentioning

confidence: 99%

Section: Recent Studies On Cnt-biofetsmentioning

confidence: 99%

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A Review of Carbon Nanotubes Field Effect-Based Biosensors

et al. 2020

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“…Such models have later been extended for modeling Si‐based biologically sensitive field effect transistors (BioFETs) . As far as CNT‐based electrochemical devices are concerned, many such devices have been thoroughly investigated numerically and experimentally considering the device physics and biochemistry . To the best of our knowledge, there is no electrochemical model for CNT‐ISFET that has taken account of the site binding and current transport concepts.…”

Section: Introductionmentioning

confidence: 99%

“…26,27 As far as CNT-based electrochemical devices are concerned, many such devices have been thoroughly investigated numerically and experimentally considering the device physics and biochemistry. [28][29][30] To the best of our knowledge, there is no electrochemical model for CNT-ISFET that has taken account of the site binding and current transport concepts. Such a modeling has importance as it gives the knowledge of device physics, helps explain experimental data, and chooses the parameters for high sensitivity and selectivity of CNT-based ISFET.…”

Section: Introductionmentioning

confidence: 99%

Modeling of carbon nanotube ISFETs with high‐κ gate dielectrics for biosensing applications

Thakur

Dutta

2019

Int J Numerical Modelling

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An electrochemical model for two fabricated CNT‐ISFETs has been developed by considering all chemical and physical parameters of the device and then simulated in MATLAB environment. Model has been developed by studying on some aspects of carbon nanotube‐based ion sensitive field effect transistor (CNT‐ISFET) with two high‐κ dielectric materials (HfO2 and ZrO2) fabricated by chemical solution process at low temperature. DC experiments have been performed on pH of the solution to determine the dependence of surface potential, threshold voltage, and drain current. Sensitivities of the devices have also been determined experimentally and found to be 57.5 and 60 mV/pH compared with theoretical values of 56.6 and 58.6 mV/pH for HfO2 and ZrO2 CNT‐ISFETs, respectively in the pH range of 5 to 9. Time domain experiments have been performed to determine the memory effects of the devices. Experiments showed drift rate of 0.52 and 0.683 mV/h at pH 7 for HfO2 and ZrO2 as gate oxides, respectively. The hysteresis widths are found to be 5.88 and 5.26 mV in a pH loop of 7 → 9 → 7 → 5 → 7 for loop time of 60 minutes, respectively, for HfO2 and ZrO2 dielectrics. The simulated results of the developed model are compared with experimentally obtained data and found to be in good agreement.

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