Fabrication and toxicity characterization of a hybrid material based on oxidized and aminated MWCNT loaded with carboplatin

Balaș, Mihaela; Constanda, Sabrina; Voiculet, Adriana; Prodana, Mariana; Pop, Sevinci; Demetrescu, Ioana; Dinischiotu, Anca

doi:10.1016/j.tiv.2016.09.011

Cited by 18 publications

(15 citation statements)

References 67 publications

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“…There is a need to elucidate specific TNBC targets on which to rely future therapies. Our previous experiments proved that carbon nanotubes are able to penetrate the TNBC cell membrane (MDA-MB-231 cell line) and to spread into the cytoplasm [15]. In line with this, the scientific literature attests that CNTs are suitable as drug carriers by penetrating into the cancerous cells directly and keeping the drug intact unmetabolized during transport in the cell [16,17], thus addressing the major shortfalls of failed TNBC therapies.…”

Section: Introductionmentioning

confidence: 87%

Cisplatin Loaded Multiwalled Carbon Nanotubes Induce Resistance in Triple Negative Breast Cancer Cells

et al. 2018

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In this paper we developed a method for multiwalled carbon nanotubes (MWCNTs) use as carriers for a drug based on platinum in breast cancer therapy. The method of functionalization involves the carboxyl functionalization of nanotubes and encapsulation of cisplatin (CDDP) into MWCNTs. The biological properties of MWCNTs loaded with CDDP (MWCNT-COOH-CDDP) and of individual components MWCNT-COOH and free CDDP were evaluated on MDA-MB-231 cells. Various concentrations of CDDP (0.316–2.52 µg/mL) and MWCNTs (0.5–4 µg/mL) were applied on cells for 24 and 48 h. Only at high doses of CDDP (1.26 and 2.52 µg/mL) and MWCNT-COOH-CDDP (2 and 4 µg/mL) cell morphological changes were observed. The cellular viability decreased only with approx. 40% after 48 h of exposure to 2.52 µg/mL CDDP and 4 µg/mL MWCNT-COOH-CDDP despite the high reactive oxygen species (ROS) production induced by MWCNTs starting with 24 h. After 48 h, ROS level dropped as a result of the antioxidant defence activation. We also found a significant decrease of caspase-3 and p53 expression after 48 h, accompanied by a down-regulation of NF-κB in cells exposed to MWCNT-COOH-CDDP system which promotes apoptosis escape and thus failing to overcome the triple negative breast cancer (TNBC) cells resistance.

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Section: Introductionmentioning

confidence: 87%

Cisplatin Loaded Multiwalled Carbon Nanotubes Induce Resistance in Triple Negative Breast Cancer Cells

et al. 2018

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“…Another study also claimed that oxidized and ammoniated multi-walled carbon nanotubes increase the autophagy activity in cancer cells. Overexpression of Beclin 1 and the reduction of Bcl 2 expression were also observed [34].…”

Section: Advances In the Therapeutic Effects Of Carbon Nanotubes On Amentioning

confidence: 94%

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

Wang¹,

Xue²

2017

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Abstract:Nervous system diseases, such as Alzheimer's disease, stroke, and Parkinson's disease, are spreading around the world. These diseases involve complicatedly pathological processes, and so far, there are no effective medicines for therapy. Another type of psychiatric disorder is induced by drugs. The synthetic drugs, represented by methamphetamine, are becoming widely abuse. At present, the cure of methamphetamine dependence is mainly symptomatic treatment, but the recurrence rate is very high. As the common brain impairments in neuropsychiatric disease, it is necessary to summary novel strategies effectively restored brain function. In recent years, carbon nanotubes have attracted the attention due to their unique properties in the field of translational medicine. Recently, new advances reported that carbon nanotubes as a nanomedicine to treat various neuropsychiatric disorders. The purpose of this review is to introduce the therapeutic approaches and mechanisms of carbon nanotubes on neuropsychiatric disorders.

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“…Both non-covalent and covalent functionalization [ 80 , 81 ] allow CNTs to be applied in biomedical purposes. Covalent functionalization is mostly performed with amino groups, by oxidation, hydrogenation, thiolation, and radical reactions [ 82 , 83 , 84 ]. On the other hand, non-covalent interactions are established between CNTs and biologically active molecules, but with the preserved intact chemical structure of the active principle.…”

Section: General Properties Of Carbon Nanomaterialsmentioning

confidence: 99%

The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity

et al. 2020

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Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly arise from their small size. They have proved to be very promising for application in the technical and biomedical field. A wide spectrum of use implies the inevitable presence of carbon nanomaterials in the environment, thus potentially endangering their whole nature. Although scientists worldwide have conducted research investigating the impact of these materials, it is evident that there are still significant gaps concerning the knowledge of their mechanisms, as well as the prolonged and chronic exposure and effects. This manuscript summarizes the most prominent representatives of carbon nanomaterial groups, giving a brief review of their general physico-chemical properties, the most common use, and toxicity profiles. Toxicity was presented through genotoxicity and the activation of the cell signaling pathways, both including in vitro and in vivo models, mechanisms, and the consequential outcomes. Moreover, the acute toxicity of fullerenol, as one of the most commonly investigated members, was briefly presented in the final part of this review. Thinking small can greatly help us improve our lives, but also obliges us to deeply and comprehensively investigate all the possible consequences that could arise from our pure-hearted scientific ambitions and work.

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Fabrication and toxicity characterization of a hybrid material based on oxidized and aminated MWCNT loaded with carboplatin

Cited by 18 publications

References 67 publications

Cisplatin Loaded Multiwalled Carbon Nanotubes Induce Resistance in Triple Negative Breast Cancer Cells

Cisplatin Loaded Multiwalled Carbon Nanotubes Induce Resistance in Triple Negative Breast Cancer Cells

Nanomedicine: A New Approach for Treatment Neuropsychiatric Diseases

The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity

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