Fabrication and properties of porous scaffold of zein/PCL biocomposite for bone tissue engineering

Wu, Fan; Wei, Jie; Liu, Changsheng; O’Neill, Brian K.; Ngothai, Yung

doi:10.1016/j.compositesb.2012.02.040

Cited by 76 publications

(53 citation statements)

References 27 publications

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“…The hydrophobicity of pristine PCL nanofibers is the major reason for a slow degradation rate and a weak cell adhesion and proliferation on the surface of the fibers. 13,36 The presence of a peak at 1123 cm 21 in FTIR spectra of Panax ginseng extract, which represents the C-C-OH group, can be a cause of pronounced hydrophilicity of ginseng containing PCL compared with the pristine one. 13 Mechanical properties of nanofibrous sheets indicated that the incorporation of Panax ginseng extract can improve the tensile strength as well as young modulus of PCL nano fibers in a dose dependent manner.…”

Section: Physical and Mechanical Characteristics Of Scaffoldsmentioning

confidence: 99%

“…Several reports have shown that the properties of PCL based scaffolds can be improved with blending the PCL polymer with other macromeres. 8,26,36 For example, PCL had an accelerated degradation and improved biocompatibility and mechanical properties when it was blended with chitosan 36 Further, hydrophilic natural polymers such as starch have been extensively utilized to improve the biocompatibility of PCL. 36 Around 25% of current prescription drugs are derived from medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

“…8,26,36 For example, PCL had an accelerated degradation and improved biocompatibility and mechanical properties when it was blended with chitosan 36 Further, hydrophilic natural polymers such as starch have been extensively utilized to improve the biocompatibility of PCL. 36 Around 25% of current prescription drugs are derived from medicinal plants. 8 Plant extracts were medically applied mostly due to their wound healing effects, anti-inflammation, anti-bacterial, anti-diabetic, and anti-cancer properties.…”

Section: Introductionmentioning

confidence: 99%

“…16 However, application of PCL scaffolds might be limited because of its low degradation rate (ranging from 2 to 4 years) which might be related to its high crystallinity, 13 and its hydrophobicity. 36 Moreover, the scaffolds made from PCL do not display the favorable mechanical properties and bioactivity 2 that are essential for bone tissue constructs. Several reports have shown that the properties of PCL based scaffolds can be improved with blending the PCL polymer with other macromeres.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Physical and Biological Modification of Polycaprolactone Electrospun Nanofiber by Panax Ginseng Extract for Bone Tissue Engineering Application

2015

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Medicinal plants as a therapeutic agent with osteogenic properties can enhance fracture-healing process. In this study, the osteo-inductive potential of Asian Panax Ginseng root extract within electrospun polycaprolactone (PCL) based nanofibers has been investigated. Scanning electron microscopy images revealed that all nanofibers were highly porous and beadles with average diameter ranging from 250 to 650 nm. The incorporation of ginseng extract improved the physical characteristics (i.e., hydrophilicity) of PCL nanofibers, as well as the mechanical properties. Although ginseng extract increased the degradation rate of pure PCL nanofibers, the porous structure and morphology of fibers did not change significantly after 42 days. It was found that nanofibrous scaffolds containing ginseng extract had higher proliferation (up to ~1.5 fold) compared to the pristine PCL. The qRT-PCR analysis demonstrated the addition of ginseng extract into PCL nanofibers induced significant expression of osteogenic genes (Osteocalcin, Runx-2 and Col-1) in MSCs in a concentration dependent manner. Moreover, higher calcium content, alkaline phosphatase activity and higher mineralization of MSCs were observed compared to the pristine PCL fibers. Our results indicated the promising potential of ginseng extract as an additive to enhance osteo-inductivity, mechanical and physical properties of PCL nanofibers for bone tissue engineering application.

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Section: Physical and Mechanical Characteristics Of Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physical and Biological Modification of Polycaprolactone Electrospun Nanofiber by Panax Ginseng Extract for Bone Tissue Engineering Application

2015

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“…. Porém, uma das principais áreas de estudo ou aplicação da PCL na medicina é no desenvolvimento de scaffolds para regeneração tecidual em ossos [162][163][164] , cartilagens [165][166][167] , vasos sanguíneos 168,169 , peles 170,172 e nervos 173,174 . Para estas aplicações são frequentemente descritas as técnicas de copolimerização ou de modificação química da superfície do scaffold, que mantêm as propriedades do material, alterando apenas sua superfície, para melhorar a biocompatibilidade 175 .…”

Section: Policaprolactonaunclassified

Biopolímeros: aplicações farmacêutica e biomédica

et al. 2016

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____________________________________________________________________________Resumo: O estudo e desenvolvimento de polímeros para aplicação nas áreas biomédica e farmacêutica têm aumentado devido às suas propriedades peculiares que contribuem para a melhoria da qualidade de vida, como por exemplo, os polímeros usados em medicina regenerativa e sistemas de liberação de fármacos. O desenvolvimento de novos materiais baseados em polímeros depende desde os métodos de síntese, extração ou composição desses materiais até os estudos da influência de suas estruturas e propriedades em aplicações específicas, entre outras. Esta revisão descreve o uso de alguns de polímeros novos e convencionais com potencial para aplicação nas áreas farmacêutica e biomédica, enfatizando as principais propriedades que os tornam aplicáveis. Palavras-chave: biopolímero, medicina regenerativa, liberação de fármacos ____________________________________________________________________________ Abstract:The study and development of polymers for pharmaceutical and biomedical use has been increasing due to their peculiar properties that contribute for the improvement of the life quality, such as the polymers used in regenerative medicine and in drug release systems. The development of new polymer based materials and its composites depends on several steps, such as the synthesis approach, the extraction, the composition, the influence of their properties on the specific applications, and others. This review describes the use of conventional and new polymers with potential application in pharmaceutical and biomedical fields, highlighting the properties that allow them to be useful for such purposes.

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