Fabrication and properties of degradable poly(amino acid)/nano hydroxyapatite bioactive composite

Zhao, Zhitong; Shan, Wenpeng; Zhang, Yunfei; Li, Xiangde; Ma, Jian; Yan, Yonggang

doi:10.1002/app.36355

Cited by 24 publications

(22 citation statements)

References 22 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MAC had two crystalline peaks at 2θ=19.9° and 2θ=23.5°, which agreed with previous studies. 14,15 The intensity of the two peaks in the MAC microspheres and BSA-loaded microspheres decreased significantly compared to the MAC raw material. The results suggest that crystallinity of the microspheres decreased throughout the double-emulsion solvent extraction process after the formation of microspheres because the solvent evaporated rapidly in a short time, and the copolymer crystallized and had loose structure in the inner water phase.…”

Section: Resultsmentioning

confidence: 99%

“…[10][11][12] Multi-(amino acid) copolymer (MAC) is the ideal degradable polymers, which has been investigated as biomaterials for bone repair and drug carriers. 13,14 Compared to the most widely used PLGA, MAC can prevent moisture-induced protein aggregation. Also, the pH value of the degrading medium does not drop as severely as that of PLGA, thus providing a more suitable microclimate for protein molecules.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation and properties of BSA-loaded microspheres based on multi-(amino acid) copolymer for protein delivery

Chen

Zhang

et al. 2014

IJN

Self Cite

View full text Add to dashboard Cite

A multi-(amino acid) copolymer (MAC) based on ω-aminocaproic acid, γ-aminobutyric acid, L-alanine, L-lysine, L-glutamate, and hydroxyproline was synthetized, and MAC microspheres encapsulating bovine serum albumin (BSA) were prepared by a double-emulsion solvent extraction method. The experimental results show that various preparation parameters including surfactant ratio of Tween 80 to Span 80, surfactant concentration, benzyl alcohol in the external water phase, and polymer concentration had obvious effects on the particle size, morphology, and encapsulation efficiency of the BSA-loaded microspheres. The sizes of BSA-loaded microspheres ranged from 60.2 μm to 79.7 μm, showing different degrees of porous structure. The encapsulation efficiency of BSA-loaded microspheres also ranged from 38.8% to 50.8%. BSA release from microspheres showed the classic biphasic profile, which was governed by diffusion and polymer erosion. The initial burst release of BSA from microspheres at the first week followed by constant slow release for the next 7 weeks were observed. BSA-loaded microspheres could degrade gradually in phosphate buffered saline buffer with pH value maintained at around 7.1 during 8 weeks incubation, suggesting that microsphere degradation did not cause a dramatic pH drop in phosphate buffered saline buffer because no acidic degradation products were released from the microspheres. Therefore, the MAC microspheres might have great potential as carriers for protein delivery.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and properties of BSA-loaded microspheres based on multi-(amino acid) copolymer for protein delivery

Chen

Zhang

et al. 2014

IJN

Self Cite

View full text Add to dashboard Cite

show abstract

“…Poly(amino acid)s (PAAs) are ubiquitous, naturally occurring polymers. A modified PAA copolymer was synthesized with ε‐aminohexanoic acid as the main framework and other natural amino acids as the block group, and this copolymer had molecular groups similar to those of collagen protein in natural bone . Also, PAA was biocompatible and bioactive when combined with inorganics of Ca–P ceramic, as we found in a previous study .…”

Section: Introductionmentioning

confidence: 75%

Effects of the surface modification of poly(amino acid)/hydroxyapatite/calcium sulfate biocomposites on the adhesion and proliferation of osteoblast‐like cells

Fan

Ren

Liu³

et al. 2015

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

In this study, we focused on the surface modification of a novel poly(amino acid) (PAA)/hydroxyapatite/calcium sulfate composite and the effect of its surface modification on cellular responses. The surface modification was performed by sandblasting (sample S2), calcium chloride ethanol saturated solution etching (sample S3), and formic acid etching (sample S4) followed by in vitro culturing of osteoblast‐like cells. The obtained results indicate that a new interface of the composite was formed during the modification, and the modified surface was changed with respect to its surface morphology by physical abrasion. The calcium chloride ethanol saturated solution etchant etched PAA selectively whereas forming rich calcium‐phosphate (Ca–P) apatite on the surface of S3. The formic acid etchant attacked the inorganic component without changing the PAA state. Cell attachment and cell proliferation were improved by the treatments of S2 and S3 in comparison with no treatment and the treatment of S4 © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42427.

show abstract

“…The PAA‐based nanocomposites were synthesized using a method of in situ melting polycondensation described in the literature . In summary, 236.00 g of 6‐aminohexanoic acid, 26.00 g of L‐hydroxyproline, and 90 mL of distilled water were added to a reaction flask and 0.5 mL of phosphorous acid (H 3 PO 3 ) was added as catalyst.…”

Section: Methodsmentioning

confidence: 99%

Poly(amino acid)/carbon nanotube nanocomposites with enhanced thermal, electrical, and mechanical properties

2018

Self Cite

View full text Add to dashboard Cite

Poly(amino acid) (PAA)‐based nanocomposites were synthesized by in situ melting polycondensation with various carbon nanotube (CNT) loadings; the morphology, thermal, mechanical, electrical, and biocompatible properties of the resulting nanocomposites were investigated and characterized. The nanotubes were dispersed within the polymer matrix without the need for coupling agents or surfactants. The crystallization temperature showed a gradual rise with increasing CNT loading, confirming that the nanotubes act as nucleating agents for PAA crystallization. The nanotubes increased the thermal stability of the matrix, leading to an increase in the initial degradation temperature (Ti) and the maximum degradation temperature (Tm). The mechanical properties were gradually enhanced by increasing the CNT content except for the property of elongation at break, which showed its highest value at 1 wt% CNT content. The nanocomposites showed better electrical and biocompatible properties than CNT‐free PAA, suggesting that the incorporation of CNTs is effective for improving the PAA performance, and the nanocomposites are suitable as performance materials for the manufacture of medical apparatus. POLYM. COMPOS., 39:E1939–E1949, 2018. © 2018 Society of Plastics Engineers

show abstract

Fabrication and properties of degradable poly(amino acid)/nano hydroxyapatite bioactive composite

Cited by 24 publications

References 22 publications

Preparation and properties of BSA-loaded microspheres based on multi-(amino acid) copolymer for protein delivery

Preparation and properties of BSA-loaded microspheres based on multi-(amino acid) copolymer for protein delivery

Effects of the surface modification of poly(amino acid)/hydroxyapatite/calcium sulfate biocomposites on the adhesion and proliferation of osteoblast‐like cells

Poly(amino acid)/carbon nanotube nanocomposites with enhanced thermal, electrical, and mechanical properties

Contact Info

Product

Resources

About