Fabrication and properties of 3D printed zirconia scaffold coated with calcium silicate/hydroxyapatite

Zhang, Hanxu; Jiao, Chen; He, Zhijing; Ge, Mengxing; Tian, Zongjun; Wang, Changjiang; Wei, Zhao; Shen, Lida; Liang, Huixin

doi:10.1016/j.ceramint.2021.06.116

Cited by 23 publications

(16 citation statements)

References 43 publications

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“…In addition, the DLP technique might be more suitable for preparing spatial lattice structures with limited thickness to give full play of their strength rather than continuum bulk materials. For example, researchers have designed several ceramic bone scaffolds for bone regeneration [32][33][34][35].…”

Section: Semmentioning

confidence: 99%

The Influence of Microstructure on the Flexural Properties of 3D Printed Zirconia Part via Digital Light Processing Technology

et al. 2022

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In recent years, additive manufacturing of ceramics is becoming of increasing interest due to the possibility of the fabrication of complex shaped parts. However, the fabrication of a fully dense bulk ceramic part without cracks and defects is still challenging. In the presented work, the digital light processing method was introduced for fabricating zirconia parts. The flexural properties of the printed zirconia were systematically investigated via a three-point bending test with the digital image correlation method, scanning electron microscopy observation and fractography analysis. Due to the anisotropy of the sample, the bending deformation behaviors of the zirconia samples in the parallel and vertical printing directions were significantly different. The flexural strength and the related elastic modulus of the samples under vertical loading were higher than that of the parallel loading, as the in-plane strength is higher than that of the interlayer strength. The maximum horizontal strain always appeared at the bottom center before the failure for the parallel loading case; while the maximum horizontal strain for the vertical loading moved upward from the bottom center to the top center. There was a clear dividing line between the minimum perpendicular strain and the maximum perpendicular strain of the samples under parallel loading; however, under vertical loading, the perpendicular strain declined from the bottom to the top along the crack path. The surrounding dense part of the sintered sample (a few hundred microns) was mainly composed of large and straight cracks between printing layers, whereas the interior contained numerous small winding cracks. The intense cracks inside the sample led to a low flexural property compared to other well-prepared zirconia samples, which the inadequate additive formulations would be the main reason for the generation of cracks. A better understanding of the additive formulation (particularly the dispersant) and the debinding-sintering process are necessary for future improvement.

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Section: Semmentioning

confidence: 99%

The Influence of Microstructure on the Flexural Properties of 3D Printed Zirconia Part via Digital Light Processing Technology

et al. 2022

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“…Compared with traditional production methods, 3D printing has the advantages of fast molding speed, high precision, and suitability for producing complex shapes. In vivo application, irregular defect sections and intricacies of simulated tissue can be assembled by precise positioning [ 75 , 76 , 77 ]. The HA granules smaller than the nozzle size are mixed with polymers and polymerized by adding a binder or by curing; the printing parameters (shape, size, pores, etc.)…”

Section: Recent Strategies For Compounding Natural and Synthetic Poly...mentioning

confidence: 99%

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

et al. 2022

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Hydroxyapatite (HA), especially in the form of HA nanoparticles (HANPs), has excellent bioactivity, biodegradability, and osteoconductivity and therefore has been widely used as a template or additives for drug delivery in clinical applications, such as dentistry and orthopedic repair. Due to the atomically anisotropic distribution on the preferred growth of HA crystals, especially the nanoscale rod-/whisker-like morphology, HA can generally be a good candidate for carrying a variety of substances. HA is biocompatible and suitable for medical applications, but most drugs carried by HANPs have an initial burst release. In the adsorption mechanism of HA as a carrier, specific surface area, pore size, and porosity are important factors that mainly affect the adsorption and release amounts. At present, many studies have developed HA as a drug carrier with targeted effect, porous structure, and high porosity. This review mainly discusses the influence of HA structures as a carrier on the adsorption and release of active molecules. It then focuses on the benefits and effects of different types of polymer-HA composites to re-examine the proteins/drugs carry and release behavior and related potential clinical applications. This literature survey can be divided into three main parts: 1. interaction and adsorption mechanism of HA and drugs; 2. advantages and application fields of HA/organic composites; 3. loading and drug release behavior of multifunctional HA composites in different environments. This work also presents the latest development and future prospects of HA as a drug carrier.

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“…The 100% coating of CS resulted in a maximum compressive strength of 50.95 MPa, that satisfies the requirements of cortical bone. When the coating % of Hap was increased, the compressive strength of the scaffold decreased …”

Section: Physical and Mechanical Characteristics Of Additive Manufact...mentioning

confidence: 99%

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

Thangavel

Elsen

2022

ACS Biomater. Sci. Eng.

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This review focuses on the advancements in additive manufacturing techniques that are utilized for fabricating bioceramic scaffolds and their characterizations leading to bone tissue regeneration. Bioscaffolds are made by mimicking the human bone structure, material composition, and properties. Calcium phosphate apatite materials are the most commonly used scaffold materials as they closely resemble live bone in their inorganic composition. The functionally graded scaffolds are fabricated by utilizing the right choice of the 3D printing method and material combinations to achieve the requirement of the bioscaffold. To tailor the physical, mechanical, and biological properties of the scaffold, certain materials are reinforced, doped, or coated to incorporate the functionality. The biomechanical loading conditions that involve flexion, torsion, and tension exerted on the implanted scaffold are discussed. The finite element analysis (FEA) technique is used to investigate the mechanical property of the scaffold before fabrication. This helps in reducing the actual number of samples used for testing. The FEA simulated results and the experimental result are compared. This review also highlights some of the challenges associated while processing the scaffold such as shrinkage, mechanical instability, cytotoxicity, and printability. In the end, the new materials that are evolved for tissue engineering applications are compiled and discussed.

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Fabrication and properties of 3D printed zirconia scaffold coated with calcium silicate/hydroxyapatite

Cited by 23 publications

References 43 publications

The Influence of Microstructure on the Flexural Properties of 3D Printed Zirconia Part via Digital Light Processing Technology

The Influence of Microstructure on the Flexural Properties of 3D Printed Zirconia Part via Digital Light Processing Technology

Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review

Review of Physical, Mechanical, and Biological Characteristics of 3D-Printed Bioceramic Scaffolds for Bone Tissue Engineering Applications

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