Fabrication and optimization of amoxicillin-loaded niosomes: an appropriate strategy to increase antimicrobial and anti-biofilm effects against multidrug-resistant <i>Staphylococcus aureus</i> strains

Shadvar, Pardis; Mirzaie, Amir; Yazdani, Shaghayegh

doi:10.1080/03639045.2022.2027958

Cited by 17 publications

(19 citation statements)

References 33 publications

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“…Liposomes are generally less stable than SLNs or NLCs, although a larger body of research exists around liposomes. Unlike SLNs and NLCs, liposomes can fuse with bacterial membranes, delivering active drug (Thorn et al 2021 ; Shadvar et al 2022 ). They can be made with rapeseed or milk-derived phospholipid, stigmasterol and hydrogenated phosphatidylcholine (Liu et al 2013 ; Vergara and Shene 2019 ; Vergara et al 2020 ) to improve stability and delay hydrolysis in the gastrointestinal environment.…”

Section: Discussionmentioning

confidence: 99%

Nanoparticular and other carriers to deliver lactoferrin for antimicrobial, antibiofilm and bone-regenerating effects: a review

2022

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Bone and joint infections are a rare but serious problem worldwide. Lactoferrin’s antimicrobial and antibiofilm activity coupled with its bone-regenerating effects may make it suitable for improving bone and joint infection treatment. However, free lactoferrin (LF) has highly variable oral bioavailability in humans due to potential for degradation in the stomach and small intestine. It also has a short half-life in blood plasma. Therefore, encapsulating LF in nanocarriers may slow degradation in the gastrointestinal tract and enhance LF absorption, stability, permeability and oral bioavailability. This review will summarize the literature on the encapsulation of LF into liposomes, solid lipid nanoparticles, nanostructured lipid carriers, polymeric micro and nanoparticles and hydroxyapatite nanocrystals. The fabrication, characterization, advantages, disadvantages and applications of each system will be discussed and compared.

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Section: Discussionmentioning

confidence: 99%

Nanoparticular and other carriers to deliver lactoferrin for antimicrobial, antibiofilm and bone-regenerating effects: a review

2022

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“…Each is approximately 20 times smaller than red blood cells. [74] A new therapeutic method for removing cancer-tumors by radiation therapy is using Auro-Shell™. That could take the necessary permissions in the treatment sector in 2002.…”

Section: Novel Methods Of Drug Delivery To Cancerousmentioning

confidence: 99%

“…This method has been used as targeted thermotherapy for breast cancer treatment. [73][74][75] This method uses antibodies that specific breast cancer cells absorb antibodies. In this way, the Nano-tubes or Auro-Shell™ connect to the particular antibody.…”

Section: Novel Methods Of Drug Delivery To Cancerousmentioning

confidence: 99%

Nano‐Biotechnology and Challenges of Drug Delivery System in Cancer Treatment Pathway: Review Article

Asadipour

Asgari

Mousavi

et al. 2023

Chemistry & Biodiversity

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In this review, we discuss Nanotechnology models, which have been developed recently in cancer treatment. Nanotechnology manipulates matter at the atomic and molecular scale to create materials with new and advanced properties. Nano‐biotechnology consists of the branches of nanotechnology that have been applied in biology (molecular and cellular genetics) and biotechnology. Nano‐biotechnology allows us to put components and compounds into cells and build new materials using new methods like assembly. Cancer is a disease caused by an uncontrolled division of abnormal cells in a part of the body. Its therapeutic methods include chemotherapy, radiation, or surgery, but the effects of these techniques are not only on tumor tissue and may affect healthy tissues. Nano‐Biotech applications regarding cancer include drug delivery, treatment, and foresight therapy. This review article aims to obtain a proper mentality of the current technologies of Nano‐biotechnology for cancer treatment.

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“…To check the stability, the optimal sample was kept for 1 month in both room and refrigerator temperatures and was evaluated in terms of %EE and size at specific time intervals 24 .…”

Section: Methodsmentioning

confidence: 99%

“…Sampling is done at different hours, in such a way that 1 mL of PBS containing the dialysis bag is removed and 1 mL of PBS with a temperature of 37 °C is replaced. Sampling is done up to 72 h in specific time intervals (1,2,4,8,24,48, and 72 h). The optical absorption of the samples was read by the UV spectrophotometer at a wavelength of 265 nm and the graph of the cumulative release percentage of SeNPs from niosome was drawn for 72 h 23 .…”

Section: Drug Release Testmentioning

confidence: 99%

Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities

Haddadian

Robattorki

Dibah

et al. 2022

Sci Rep

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Targeted drug delivery and increasing the biological activity of drugs is one of the recent challenges of pharmaceutical researchers. Niosomes are one of the new targeted drug delivery systems that enhances the biological properties of drugs. In this study, for the first time, the green synthesis of selenium nanoparticles (SeNPs), and its loading into niosome was carried out to increase the anti-bacterial and anti-cancer activity of SeNPs. Different formulations of noisome-loaded SeNPs were prepared, and the physical and chemical characteristics of the prepared niosomes were investigated. The antibacterial and anti-biofilm effects of synthesized niosomes loaded SeNPs and free SeNPs against standard pathogenic bacterial strains were studied, and also its anticancer activity was investigated against breast cancer cell lines. The expression level of apoptotic genes in breast cancer cell lines treated with niosome-loaded SeNPs and free SeNPs was measured. Also, to evaluate the biocompatibility of the synthesized niosomes, their cytotoxicity effects against the human foreskin fibroblasts normal cell line (HFF) were studied using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The results illustrated that the optimal formulation had an average size of 177.9 nm, a spherical shape, and an encapsulation efficiency of 37.58%. Also, the results revealed that the release rate of SeNPs from niosome-loaded SeNPs and free SeNPs was 61.26% and 100%, respectively, in 72 h. Also, our findings demonstrated that the niosome-loaded SeNPs have significant antibacterial, anti-biofilm, and anticancer effects compared to the free SeNPs. In addition, niosome-loaded SeNPs can upregulate the expression level of Bax, cas3, and cas9 apoptosis genes while the expression of the Bcl2 gene is down-regulated in all studied cell lines, significantly. Also, the results of the MTT test indicated that the free niosome has no significant cytotoxic effects against the HFF cell line which represents the biocompatibility of the synthesized niosomes. In general, based on the results of this study, it can be concluded that niosomes-loaded SeNPs have significant anti-microbial, anti-biofilm, and anti-cancer effects, which can be used as a suitable drug delivery system.

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Fabrication and optimization of amoxicillin-loaded niosomes: an appropriate strategy to increase antimicrobial and anti-biofilm effects against multidrug-resistant Staphylococcus aureus strains

Cited by 17 publications

References 33 publications

Nanoparticular and other carriers to deliver lactoferrin for antimicrobial, antibiofilm and bone-regenerating effects: a review

Nanoparticular and other carriers to deliver lactoferrin for antimicrobial, antibiofilm and bone-regenerating effects: a review

Nano‐Biotechnology and Challenges of Drug Delivery System in Cancer Treatment Pathway: Review Article

Niosomes-loaded selenium nanoparticles as a new approach for enhanced antibacterial, anti-biofilm, and anticancer activities

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