Fabrication and evaluation of Zn containing fluoridated hydroxyapatite layer with Zn release ability

Miao, Shundong; Cheng, Kui; Weng, Wenjian; Du, Piyi; Shen, Ge; Han, Gaorong; Yan, Wei; Zhang, Sam

doi:10.1016/j.actbio.2007.08.013

Cited by 68 publications

(39 citation statements)

References 27 publications

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“…Alizarin red S quantification revealed that the percentage of mineralized nodules increased with the Zn/Ca mol ratio and cells on the Zn-Ca 0.3 coating after 21 days had higher levels of calcium nodule formation than that in other groups. The results were in agreement with previous studies showing that Zn plays an important role in osteoblastic bone formation and mineralization and that Zn-containing implants could improve osteoblastic function through proper Zn-ion release 54, 55 . However, little is known about the mechanism underlying the Zn-modified coating promotion of osteogenic differentiation and bone regeneration.…”

Section: Discussionsupporting

confidence: 93%

Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits

et al. 2017

Sci Rep

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Surface-modified metal implants incorporating different ions have been employed in the biomedical field as bioactive dental implants with good osseointegration properties. However, the molecular mechanism through which surface coatings exert the biological activity is not fully understood, and the effects have been difficult to achieve, especially in the osteopenic bone. In this study, We examined the effect of zinc-modified calcium silicate coatings with two different Zn contents to induce osteogenic differentiation of rat bone marrow-derived pericytes (BM-PCs) and osteogenetic efficiency in ovariectomised rabbits. Ti-6Al-4V with zinc-modified calcium silicate coatings not only enhanced proliferation but also promoted osteogenic differentiation and mineralized matrix deposition of rat BM-PCs as the zinc content and culture time increased in vitro. The associated molecular mechanisms were investigated by Q-PCR and Western blotting, revealing that TGF-β/Smad signaling pathway plays a direct and significant role in regulating BM-PCs osteoblastic differentiation on Zn-modified coatings. Furthermore, in vivo results that revealed Zn-modified calcium silicate coatings significantly promoted new bone formation around the implant surface in osteopenic rabbits as the Zn content and exposure time increased. Therefore, Zn-modified calcium silicate coatings can improve implant osseointegration in the condition of osteopenia, which may be beneficial for patients suffering from osteoporosis-related fractures.

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Section: Discussionsupporting

confidence: 93%

Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits

et al. 2017

Sci Rep

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“…The cell morphologies observed for other Zn 2 þ included samples supported the study of Xue et al [70]. Similarly, in a study by Miao et al, SEM observations showed that human osteoblast-like MG63 cells had dendritic shapes and a diameter of 50 mm on Zn 2 þ doped samples [12]. The group observed spherical cell bodies on the samples without Zn 2 þ with SEM [15].…”

Section: In Vitro Biocompatibility Studiessupporting

confidence: 60%

“…This crucial element has an important role in the activity of many enzymes and its uptake and release are strongly mediated by the bone reservoir in the body [12]. Additionally, antibacterial and antifungal effects of Zn doped HA against Escherichia coli, Staphylococcus aureus and pathogen yeast Candida albicans were also documented in solid and liquid media [13].…”

Section: Introductionmentioning

confidence: 99%

Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Uysal

Severcan

Tezcaner

et al. 2014

Progress in Natural Science: Materials International

105

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Hydroxyapatite (HA) co-doped with Zn 2 þ and F À ions was synthesized by precipitation method for the first time in this study. FTIR spectroscopy revealed Zn 2 þ and F À ions incorporation into HA structure. Co-doping of Zn 2 þ and F À ions decreased unit cell volume of HA and decreased grain sizes. Zn 2 þ or 5 mol% F À addition into HA significantly improved its density. Microhardness was increased with Zn 2 þ addition and further increase was detected with F À co-doping. Zn 2 þ and F À co-doped samples had higher fracture toughness than pure HA. Zn 2 þ incorporation to the structure resulted in an increase in cell proliferation and ALP activity of cells, and further increase was observed with 1 mol% F À addition. With superior mechanical properties and biological response 2Zn1F is a good candidate for biomedical applications.

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“…HA coatings with ionic substitutions have been produced to stimulate bone binding to an implant surface. The substitution of Zn 2+ and Sr 2+ for Ca 2+ , the substitution of SiO 4 4 − and CO 3 2 − for PO 4 3 − and the substitution of F − for OH − have been shown to stimulate bone cell adhesion to an implant and to enhance the stability of coatings [19][20][21]. The incorporation of F − into the HA structure reduces the lattice parameters and the unit cell volume, resulting in a structure with a higher hardness and a lower dissolution rate [22,23].…”

Section: Introductionmentioning

confidence: 99%

Crystalline nano-coatings of fluorine-substituted hydroxyapatite produced by magnetron sputtering with high plasma confinement

López

Rossi

Archanjo

et al. 2015

Surface and Coatings Technology

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a b s t r a c tA radio-frequency magnetron sputtering technique operating in right-angle geometry (RAMS) with high plasma confinement was revised to produce thin films (15-570 nm) of fluorine-substituted hydroxyapatite, FHA, adapted to be used as nano-coatings for biomedical implants. An electron temperature of T eff ≈ 9.0 eV and a plasma electron density of 1.2 × 10 15 m −3 assured the nucleation of an amorphous fluorine-substituted hydroxyapatite phase on Si and Ti surfaces. With the aid of a Langmuir probe, the RAMS plasma energy was tuned to control the coating stoichiometry and the ratio between the crystalline and amorphous phases. The energy delivered over time from the bombardment of ions and electrons transformed the amorphous calcium phosphate phase into crystalline fluorine-substituted hydroxyapatite. The crystalline films were obtained at room temperature. The partial substitution of OH − for F − in the HA structure was confirmed by X-ray diffraction using synchrotron radiation in grazing-incidence mode, X-ray photoelectron spectroscopy and attenuated total reflection Fourier transform infrared spectroscopy. High-resolution transmission electron microscopy carried out on crosssection film samples prepared by a focused ion beam (FIB) technique revealed that the film ultrastructure was composed of columnar crystals oriented perpendicularly to the substrate surface. The crystals were connected to the substrate surface by ordered nanolayers, indicating the existence of a continuous binding between the two materials. This work demonstrates that the RAMS technique is able to produce FHA nano-coatings with controlled chemical compositions and structures on metallic implants for clinical applications.

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Fabrication and evaluation of Zn containing fluoridated hydroxyapatite layer with Zn release ability

Cited by 68 publications

References 27 publications

Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits

Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits

Co-doping of hydroxyapatite with zinc and fluoride improves mechanical and biological properties of hydroxyapatite

Crystalline nano-coatings of fluorine-substituted hydroxyapatite produced by magnetron sputtering with high plasma confinement

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