Fabrication and evaluation of nanoencapsulated quercetin for wound healing application

Nalini, T.; Basha, Sakeenabi; Sadiq, A. Mohamed; Kumari, V. Sugantha

doi:10.1007/s00289-022-04094-5

Cited by 17 publications

(3 citation statements)

References 67 publications

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“…Quercetin, a key bioflavonoid present in onions, apples, tea, brassica vegetables, nuts, seeds, bark, flowers and leaves, can also be extracted from various medicinal plants. It has been demonstrated to have therapeutic effects in wound healing, neuroprotection, vitiligo and other conditions [ 111 , 112 , 113 , 114 ]. A notable feature of quercetin is its structural abundance of OH groups ( Table 2 ), which enables it to bind to ROS, preserving cell viability and exhibiting a higher antioxidant capacity than many other flavonoids [ 115 ].…”

Section: Major Plant-derived Compounds That Modulate Fibrosismentioning

confidence: 99%

Potential of Plant-Derived Compounds in Preventing and Reversing Organ Fibrosis and the Underlying Mechanisms

Azeredo,

Fan,

Murphy

et al. 2024

Cells

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Increased production of extracellular matrix is a necessary response to tissue damage and stress. In a normal healing process, the increase in extracellular matrix is transient. In some instances; however, the increase in extracellular matrix can persist as fibrosis, leading to deleterious alterations in organ structure, biomechanical properties, and function. Indeed, fibrosis is now appreciated to be an important cause of mortality and morbidity. Extensive research has illustrated that fibrosis can be slowed, arrested or even reversed; however, few drugs have been approved specifically for anti-fibrotic treatment. This is in part due to the complex pathways responsible for fibrogenesis and the undesirable side effects of drugs targeting these pathways. Natural products have been utilized for thousands of years as a major component of traditional medicine and currently account for almost one-third of drugs used clinically worldwide. A variety of plant-derived compounds have been demonstrated to have preventative or even reversal effects on fibrosis. This review will discuss the effects and the underlying mechanisms of some of the major plant-derived compounds that have been identified to impact fibrosis.

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Section: Major Plant-derived Compounds That Modulate Fibrosismentioning

confidence: 99%

Potential of Plant-Derived Compounds in Preventing and Reversing Organ Fibrosis and the Underlying Mechanisms

Azeredo,

Fan,

Murphy

et al. 2024

Cells

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“…There was the sustained release of quercetin, which can be correlated with the therapeutic mechanism responsible for enhanced wound healing and so the Q–ALG/CSNPs system is a good polymer system for wound healing applications. 152 Quercetin was loaded onto graphene oxide (GO) nanoparticles. Polycaprolactone nanofibers were fabricated with varying concentrations of GO/Q nanocomposites using the electrospinning procedure.…”

Section: Naturally Occurring Materials Fabricated Into Wound Dressing...mentioning

confidence: 99%

A review of past promises, present realities and a vibrant future for wound dressing from naturally occurring to sustainable materials

H.,

Tripathi,

Bose

2023

RSC Sustain.

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“…Record the absorbance values corresponding to each known concentration in a data table. This calibration equation can subsequently be utilized to determine the concentration of quercetin in unknown samples based on their measured absorbance values, facilitating quantitative analysis [14].…”

Section: Establishing the Ethanol Standard Curvementioning

confidence: 99%

Synthesis of Quercetin-Loaded Silver Nanoparticles and Assessing Their Anti-Bacterial Potential

Sharma,

Basist,

Alhalmi

et al. 2023

Micromachines

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The study delves into the multifaceted potential of quercetin (Qu), a phytoconstituent found in various fruits, vegetables, and medicinal plants, in combination with silver nanoparticles (AgNPs). The research explores the synthesis and characterization of AgNPs loaded with Qu and investigates their pharmaceutical applications, particularly focusing on antibacterial properties. The study meticulously evaluates Qu’s identity, and physicochemical properties, reaffirming its suitability for pharmaceutical use. The development of Qu-loaded AgNPs demonstrates their high drug entrapment efficiency, ideal particle characteristics, and controlled drug release kinetics, suggesting enhanced therapeutic efficacy and reduced side effects. Furthermore, the research examines the antibacterial activity of Qu in different solvents, revealing distinct outcomes. Qu, both in methanol and water formulations, exhibits antibacterial activity against Escherichia coli, with the methanol formulation displaying a slightly stronger efficacy. In conclusion, this study successfully synthesizes AgNPs loaded with Qu and highlights their potential as a potent antibacterial formulation. The findings underscore the influence of solvent choice on Qu’s antibacterial properties and pave the way for further research and development in drug delivery systems and antimicrobial agents. This innovative approach holds promise for addressing microbial resistance and advancing pharmaceutical formulations for improved therapeutic outcomes.

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Fabrication and evaluation of nanoencapsulated quercetin for wound healing application

Cited by 17 publications

References 67 publications

Potential of Plant-Derived Compounds in Preventing and Reversing Organ Fibrosis and the Underlying Mechanisms

Potential of Plant-Derived Compounds in Preventing and Reversing Organ Fibrosis and the Underlying Mechanisms

A review of past promises, present realities and a vibrant future for wound dressing from naturally occurring to sustainable materials

Synthesis of Quercetin-Loaded Silver Nanoparticles and Assessing Their Anti-Bacterial Potential

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