Fabrication and evaluation of electrospun PCL–gelatin micro-/nanofiber membranes for anti-infective GTR implants

Xue, Jiajia; He, Min; Liang, Yuanzhe; Crawford, Aileen; Coates, Phil; Chen, Dafu; Shi, Rui; Zhang, Liqun

doi:10.1039/c4tb00737a

Cited by 104 publications

(77 citation statements)

References 39 publications

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“…[33,41] Many reports have emphasized that carbonaceous materials can enhance the electronic conductivity and provide extra capacity to enhance the Li-ion storage capability for the LTO material, but unfortunately, no insightful explanation on the mechanism has been provided. [44][45][46][47] Here, we illustrated the mechanism of the superior Li-ion storage ability of rGO-based LTO materials through the assistant of in situ Raman tests, which can also be extended to other carbonaceous-based LTO materials.…”

Section: Resultsmentioning

confidence: 99%

Engineering of Oxygen Vacancy and Electric‐Field Effect by Encapsulating Lithium Titanate in Reduced Graphene Oxide for Superior Lithium Ion Storage

Meng

et al. 2019

Small Methods

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Rational design of nanostructured electrode materials is highly desired for developing high‐performance lithium‐ion batteries (LIBs). Encapsulating electrode materials in reduced graphene oxide (rGO) shows great potential for manipulation of physicochemical properties at the atomic level, promoting remarkable electrochemical properties. Here, a controllable strategy is proposed to synthesize a “pomegranate‐like” 3D rGO encapsulated lithium titanate composite (CT‐rGO@LTO). The experimental results demonstrate the enriched oxygen vacancies in LTO and the electronic interactions at the interface between LTO and rGO. Density functional theory (DFT) calculations confirm the charge redistribution in the CT‐rGO@LTO composite, establishing a strong electric field with oxygen vacancies. Furthermore, the extra active sites in rGO for Li‐ion storage are investigated via in situ Raman tests. Benefiting from the oxygen vacancies and the electric‐field effect, the CT‐rGO@LTO electrode delivers excellent cycling stability with a capacity retention of 87.1% after 1500 cycles at 5 C. Moreover, the CT‐rGO@LTO electrode is adopted to assemble a full cell with a LiCoO2 cathode, which also displays superior rate capability with capacities of 139.4 and 109.7 mA h g−1 at 0.5 and 10 C, respectively. This work provides profound insights of fabricating high‐performance electrode materials for advanced energy storage.

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Section: Resultsmentioning

confidence: 99%

Engineering of Oxygen Vacancy and Electric‐Field Effect by Encapsulating Lithium Titanate in Reduced Graphene Oxide for Superior Lithium Ion Storage

Meng

et al. 2019

Small Methods

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“…Histological analysis of transverse sections at the middle sites were performed by staining with hematoxylin and eosin (H&E), and Masson's trichrome to observe the inammatory response. 26,32,33 During the experiment, all mice remained in good health, with no wound complications. For all nanobrous tubular scaffolds, no acute or chronic inammation, necrosis, or adverse tissue reactions were identied.…”

Section: Histological Analysis Aer Subcutaneous Implantationmentioning

confidence: 92%

Preparation and evaluation of poly(ester-urethane) urea/gelatin nanofibers based on different crosslinking strategies for potential applications in vascular tissue engineering

et al. 2018

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“…Drug is continuously released from polymer due to the interaction between the drug and polymer. Therefore, the compatibility of the drug and polymer is an important factor in drug release efficiency [33,34].…”

Section: Release Test Of Md/paamentioning

confidence: 99%

Preparation of Radiation Cross-Linked Poly(Acrylic Acid) Hydrogel Containing Metronidazole with Enhanced Antibacterial Activity

Jeong

Park

Kim

et al. 2019

IJMS

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Metronidazole (MD) is known as a periodontitis medicine and has been widely used in antibiotics for resistance to anaerobic bacteria, periodontal disease, and other threats. To treat diseases, drug delivery carriers are needed with a high bioadhesive property and enhanced drug penetration. Poly (acrylic acid) (PAA) hydrogel films have a good bioadhesive property and are able to localize the absorption site and increase the drug residence time. In this study, we fabricated a MD loaded PAA hydrogel with different MD content (0.1, 0.25, 0.5, and 1 wt%) using varying doses (25, 50, and 75 kGy) and the radiation doses (25, 50, or 75 kGy) in a one-step gamma-ray irradiation process. The chemical and physical structure were determined through a Fourier transformed infrared spectroscopy, X-ray photoelectron spectroscopy, gel content, and compressive strength. In addition, MD loaded PAA hydrogels were performed to MD release behaviors and cytotoxicity. Finally, we conducted antibacterial activity to demonstrate the prevention of growth of bacteria as a therapeutic dressing. The basic chemical structure analysis of MD was changed greatly at radiation doses of 50 and 75 kGy due to degradation by gamma-ray irradiation. However, when the absorbed dose was 25 kGy, the chemical structure analysis of MD did not change significantly, and the gel content and compressive strength of MD/PAA hydrogel were approximately 80% and 130 kPa, respectively. The MD/PAA hydrogels exhibited no cytotoxicity and good antibacterial activity against Escherichia coli, Staphylococcus aureus, and Streptococcus mutans. These results provide good evidence that MD/PAA hydrogel prepared by gamma-ray irradiation has potential as a competitive candidate for the therapeutic dressing.

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Fabrication and evaluation of electrospun PCL–gelatin micro-/nanofiber membranes for anti-infective GTR implants

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Cited by 104 publications

References 39 publications

Engineering of Oxygen Vacancy and Electric‐Field Effect by Encapsulating Lithium Titanate in Reduced Graphene Oxide for Superior Lithium Ion Storage

Engineering of Oxygen Vacancy and Electric‐Field Effect by Encapsulating Lithium Titanate in Reduced Graphene Oxide for Superior Lithium Ion Storage

Preparation and evaluation of poly(ester-urethane) urea/gelatin nanofibers based on different crosslinking strategies for potential applications in vascular tissue engineering

Preparation of Radiation Cross-Linked Poly(Acrylic Acid) Hydrogel Containing Metronidazole with Enhanced Antibacterial Activity

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