Fabrication and Development of Pectin Microsphere of Metformin Hydrochloride

Abstract

Purpose. The objective of the proposed work is to evaluate the efficacy of Pectins to qualify them as polymers for designing an oral microsphere for the delivery of selected oral antidiabetic drug-like metformin hydrochloride. Methods. Different Microspheres formulations were prepared by the water in oil (w\o) emulsion solvent evaporation technique and subsequently evaluated for its different physical parameters as well as its in vitro and in vivo drug release study. Results. The formulations F2 (98.42) and F3 (98.03) showed a constant and high release in the dissolution profile, so among these two formulations, F2 was taken for development study, due to the better result shown over in other evaluation parameters. From the HPLC determinations after in vivo study, it had been found that the test samples and the standard sample had not shown any significant fluctuation in relation to their retention time. Conclusion. From in vitro and in vivo results, it may be concluded that drug-loaded pectin microspheres in 1 : 1 ratio are a suitable delivery system for metformin hydrochloride and may be used for effective management of NIDDM. From this experiment, it could be concluded that as a natural polymer, pectin has potentiality in novel drug delivery system.

Microparticulate and nanoparticulate drug delivery systems for metformin hydrochloride

“…The authors reported that pectin microspheres showed better controlled release of metformin HCl compared to microspheres made of the other polymers. When the effects of metformin HCl-containing pectin microspheres and pure drug (equivalent 25 mg/kg body weight) were evaluated on diabetic rats after oral administration, it was found that microspheres continuously decreased the blood glucose level for about 5 h (from 297.5 to 173 mg/dL) compared to that of pure drug (maximum decrease obtained at 1 h, from 298.7 to 134.4 mg/dL) (Banerjee et al, 2012). Wang et al (2013) extracted a crude polysaccharide from the Mactra veneriformis (a marine clam; it is used as a seafood and also in traditional Chinese medicine).…”

Evaluation of two novel plant gums for bioadhesive microsphere and sustained-release formulations of metformin hydrochloride

“…17 Different drug : polymer ratios were used ( Table 1). The drug (500 mg) and the gum (500, 1000, 1500 or 2000 mg) were dispersed in water.…”

“…The size and distribution was adequate for optimum absorption across the mucosal layer, the stirring and speed employed in the formulation process probably accounted for the narrow range of particle sizes. 17 Representative images from the morphological studies of the polymers and microspheres by Scanning Electron Microscopy are presented in Fig. 4d-e.…”

“…17 Also, the dissolution rate of metformin hydrochloride in phosphate buffer (pH 6.8) was studied in different formulations and was found to be as high as between 96.27 and 97.93%. 18 This paper evaluates the solid-state characteristics and physicochemical properties of 2 novel plant gums (enterolobium and cedrela gums) in the formulation of bioadhesive microspheres loaded with metformin hydrochloride with the target of reducing the dosing frequency of metformin through a sustained-release drug delivery system.…”

Preparation of CEL2 glass‐ceramic porous scaffolds coated with chitosan microspheres that have a drug delivery function

“…[15][16][17][18][19][20][21][22][23][24] The drugs encapsulated in chitosan microspheres include anticancer agents, anti-inflammatory agents, antibiotics, antihypertensive agents, peptide drugs, proteins, and vaccines. [26][27][28][29][30] Polymer coatings are also known to be drug carriers, providing a viable manner to avoid the risks of side effects associated with oral or parenteral therapies. [26][27][28][29][30] Polymer coatings are also known to be drug carriers, providing a viable manner to avoid the risks of side effects associated with oral or parenteral therapies.…”