Fabrication and characterization of soy β-conglycinin-dextran-polyphenol nanocomplexes: Improvement on the antioxidant activity and sustained-release property of curcumin

Glycated Soy β-Conglycinin Nanoparticle for Efficient Nanocarrier of Curcumin: Formation Mechanism, Thermal Stability, and Storage Stability

“…The particle size of the 7S-Cur nanocomplexes was around 60 nm smaller than of 7S-150-Cur (approximately 90 nm), which is in keeping with the results of DLS. Both the 7S-Cur and 7S-150-Cur nanocomplexes exhibited a spheroid shape with uniform dispersion, suggesting that the obtained nanocomplexes had a stable structure [ 7 ]. Meanwhile, the solutions of 7S-Cur and 7S-150-Cur were clear and transparent, suggesting that the curcumin nanocomplexes were uniformly dispersed in water.…”

“…Protein-based nanoparticles have been commonly used as nanocarriers for curcumin because of their excellent biosafety, biocompatibility, and biodegradability [ 6 ]. Many proteins, for example, whey proteins, soy protein, and bovine serum albumin simply bind bioactives to the surface through hydrophobic interactions, resulting in a limited curcumin loading amount, and accelerated the instability of nanocomplexes [ 7 , 8 , 9 ]. Some proteins, for example, β-casein [ 10 ] and soy β-conglycinin [ 8 ], have a unique nanostructure that can be disassembled to expose more binding sites for curcumin, and then reassembled to encapsulate curcumin within the self-assembled structure, which enabled them to be developed as high-encapsulation-performance nanocarriers for curcumin by the self-assembly technology.…”

“…The subunits of 7S are connected by non-covalent interactions [ 11 ]. Based on this unique characteristic, 7S can be disassembled and reassembled induced by many methods such as the pH-driven strategy [ 7 ], ethanol-assisted strategy [ 12 ], and urea-assisted strategy [ 8 ]. Meanwhile, 7S has been successfully used to prepare nanocomplexes with curcumin and have exhibited a high encapsulation efficiency [ 7 , 8 ].…”

“…Based on this unique characteristic, 7S can be disassembled and reassembled induced by many methods such as the pH-driven strategy [ 7 ], ethanol-assisted strategy [ 12 ], and urea-assisted strategy [ 8 ]. Meanwhile, 7S has been successfully used to prepare nanocomplexes with curcumin and have exhibited a high encapsulation efficiency [ 7 , 8 ]. However, as a protein, native 7S is highly vulnerable to environmental stresses (including extreme pH and high temperature), which has limited the application of natural 7S as a nanocarrier for hydrophobic nutrients in the food industry [ 13 ].…”

“…In the past study, Xu et al [ 13 ] have reported that glycation could effectively increase the thermal stability of 7S nanoparticles. Meanwhile, our recent study has demonstrated that 7S-DEX conjugates have a similar pH-driven self-assemble ability as natural 7S [ 7 ]. Results showed that encapsulation within 7S-DEX conjugates could greatly improve the sustained-release property and antioxidant activity of curcumin.…”