Fabrication and characterization of self-assembled whey protein isolate/short linear glucan core–shell nanoparticles for sustained release of curcumin

Li, Xiaojing; Xu, Ting; Wu, Caie; Fan, Gongjian; Li, Tingting; Wang, Yaosong; Zhou, Dandan

doi:10.1016/j.foodchem.2022.135124

Cited by 17 publications

(9 citation statements)

References 40 publications

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“…2e). Li et al 35 reported the use of self-assembled WPI/short linear dextran core–shell nanoparticles for controlled curcumin release under gastrointestinal conditions. The nanoparticles exhibited low cytotoxicity at higher concentrations, concurrently enhancing both the DPPH scavenging activity and reducing capacity of curcumin.…”

Section: Resultsmentioning

confidence: 99%

Orally administered dual-targeted astaxanthin nanoparticles as novel dietary supplements for alleviating hepatocyte oxidative stress

Zhang,

Shaukat,

Liu

et al. 2024

Food Funct.

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Section: Resultsmentioning

confidence: 99%

Orally administered dual-targeted astaxanthin nanoparticles as novel dietary supplements for alleviating hepatocyte oxidative stress

Zhang,

Shaukat,

Liu

et al. 2024

Food Funct.

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“…The LC (%) of APIs (Cur, Pio) into CS NPs was measured based on the method reported in literature [19]. A quantity of freeze-dried CS-APIs NPs (0.008 g CS-Pio NPs; 0.01 g CS-Cur NPs; 0.013 g CS-Pio-Cur NPs) was treated with ethanol (10 mL) The mixture was sonicated for 5 min and after that was centrifuged for 10 min at 15.000 rpm at 4 ° C. Then, the supernatant was used to measure the absorbance at 424 nm (for Cur) and 272 nm (for Pio) respectively [20,21].…”

Section: The Entrapment Efficiency (Ef) and Loading Capacity (Lc)mentioning

confidence: 99%

Simultaneous Determination of Pioglitazone and Curcumin from Chitosan-Based Co-delivery Nanosystem for Diabetes Mellitus Therapy

Sava,

Lupascu,

Tătărușanu

et al. 2024

Preprint

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Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement of oxidative stress in its onset and progression. Pioglitazone (Pio) is an antidiabetic drug which primarily works by reducing insulin resistance while Curcumin (Cur) is powerful antioxidant with o important hypoglycemic effect, also. The both drugs are associated with several drawbacks, such as reduced bioavailability, a short half-life time (Pio) as well as instability and poor water solubility (Cur), which limit their therapeutic use. In order to overcome these disadvantages, a new co-delivery (Pio, Cur) nanosystem based chitosan (CS) (CS-Pio-Cur NPs), was developed, and characterized in reference with simple nanosystems (CS-Pio NPs, CS-Cur NPs). The developed CS-based NPs (CS-Pio-Cur NPs, CS-Pio NPs, CS-Cur NPs) were physico-chemical characterized in terms of particle size (PS), entrapment efficiency (EF%) and loading capacity (LC%). The CS-Pio-Cur NPs proved increased or similar values of EE (88.95% ± 7.79 for Cur; 94.83% ± 9.89 for Pio) and LC% (24.25 % ± 1.62 for Cur; 3.5% ± 0.98 for Pio), in reference with simple nanosystems, CS-Cur NPs (EE = 82.46% ± 1.74; LC = 20.34% ± 0.94) and CS-Pio NPs) (EE = 96.31% ± 0.68; LC = 4.11% ± 0.47), respectively. The identification of APIs (Cur, Pio) loaded into CS matrix was performed using FR-IR spectroscopy and for simultaneously quantification of APIs (Cur, Pio) released from CS-Pio-Cur NPs, a HLPC method was developed and validated. Based on release study performed in different simulated fluids (SGF, SIF, SCF) it can be appreciated that developed CS-APIs NPs have favorable pharmacokinetic profile with good release in gastrointestinal tract.

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“…In addition, Cur has low cost, high safety, and is often used in medicine and food processing (Gayathri et al., 2023). Despite having a wide range of beneficial biological functions, the application of Cur as a bioactive agent in various functional products or pharmacological formulations has been limited due to its low aqueous solubility and poor chemical stability under high light, temperature, and oxygenation conditions (Li et al., 2023).…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, protein‐based delivery systems are a cheap and easy way to deliver bioactive components due to their good self‐assembling nature, high water solubility, and surface‐active properties (Tavares et al., 2014). There are numerous studies on the interaction and properties of Cur through complexation with food proteins, such as pea proteins (Zhang et al., 2020), lotus seed protein (Su et al., 2021), caseins (Du et al., 2023), whey protein isolate (WPI) (Li et al., 2023), and bovine serum albumin (Hudson et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, WP has been used to fabricate microgels to improve Cur stability and antioxidant properties, with a Cur loading amount of 17.51 ± 0.46 µg mg −1 protein (Mohammadian et al., 2018). The Cur‐loaded WPI/short linear glucan core–shell fabricated by self‐assembly remained relatively stable under various pH conditions (2–4 and 8–10), high temperatures (60–70°C), and ionic strengths (<400 mM), as well as showing little cytotoxicity at high concentrations and significantly enhancing the DPPH scavenging activity and reducing the power of Cur (Li et al., 2023).…”

Section: Introductionmentioning

confidence: 99%

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Interaction between curcumin and ultrafiltered casein micelles or whey protein, and characteristics of their complexes

Wu,

Qin,

et al. 2024

Journal of Food Science

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This work evaluated the interaction between micellar casein (MC) or whey protein (WP) in ultrafiltration retentate with curcumin (Cur), as well as the physicochemical and functional properties of Cur–MC and Cur–WP complexes. The MC had a higher affinity for Cur than WP, shown by higher binding constants of Cur–MC at various temperatures. Thermodynamic analysis of the binding process indicated that the interaction between Cur and MC or WP was hydrophobic in nature. Cur promoted the size and polydispersity index of MC and WP at 4 mM but did not alter the morphology of spray‐dried MC and WP. The Cur–MC complexes showed better aqueous solubility at pH 2–3 and 6–10 compared to free MC. Combination with MC or WP improved the 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonate) radical scavenging activity of Cur. In addition, combination with MC and WP promoted cumulative release of Cur during simulated gastrointestinal digestion, especially for WP. Thus, MC and WP in retentates can be good alternative protein‐based carriers for Cur delivery, whereas their complexes in powder form have good functional properties that could be used as active food ingredients in several food formulations.Practical ApplicationMicrofiltration is a cheap and convenient approach that can be used to easily produce micellar casein (MC), with whey protein (WP) as one byproduct. In this study, we proved that MC and WP in retentates have strong interaction with curcumin (Cur), whereas their complexes have good functional properties. Thus, spray‐dried MC–Cur or WP–Cur complexes could be used as active food ingredients in several food formulations.

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Fabrication and characterization of self-assembled whey protein isolate/short linear glucan core–shell nanoparticles for sustained release of curcumin

Cited by 17 publications

References 40 publications

Orally administered dual-targeted astaxanthin nanoparticles as novel dietary supplements for alleviating hepatocyte oxidative stress

Orally administered dual-targeted astaxanthin nanoparticles as novel dietary supplements for alleviating hepatocyte oxidative stress

Simultaneous Determination of Pioglitazone and Curcumin from Chitosan-Based Co-delivery Nanosystem for Diabetes Mellitus Therapy

Interaction between curcumin and ultrafiltered casein micelles or whey protein, and characteristics of their complexes

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