Fabrication and characterization of poly (vinyl alcohol)/chitosan blend nanofibers produced by electrospinning method

Jia, Yongtang; Gong, Jian; Liu, Siwen; Kim, Hee Young; Dong, Jiong; Shen, Xinyuan

doi:10.1016/j.carbpol.2006.06.010

Cited by 509 publications

(283 citation statements)

References 27 publications

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“…6 Synthetic polymers include poly(e-caprolactone) (PCL), 36,37 poly(l-lactic acid) (PLLA), 24 polyurethane, 26 copolymers of poly(ethylene glycol) (PEG) and PCL, 38 poly(l-lactic acidco-e-caprolactone) (P(LLA-CL)), 23,39 and poly (d,l-lacticco-glycolic acid) (PLGA). 40,41 Additionally, composite fibers can be created, such as chitosan-poly(vinyl alcohol) nanofibers 42 and silk, PEO, and hydroxyapatite nanoparticle composites. 43 Fibers containing a blend of collagen and elastin were electrospun with diameters ranging from 220 to 600 nm.…”

Section: Electrospinningmentioning

confidence: 99%

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Polymeric Nanofibers in Tissue Engineering

Dahlin

Kasper

Mikos

2011

Tissue Engineering Part B: Reviews

293

198

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Polymeric nanofibers can be produced using methods such as electrospinning, phase separation, and selfassembly, and the fiber composition, diameter, alignment, degradation, and mechanical properties can be tailored to the intended application. Nanofibers possess unique advantages for tissue engineering. The small diameter closely matches that of extracellular matrix fibers, and the relatively large surface area is beneficial for cell attachment and bioactive factor loading. This review will update the reader on the aspects of nanofiber fabrication and characterization important to tissue engineering, including control of porous structure, cell infiltration, and fiber degradation. Bioactive factor loading will be discussed with specific relevance to tissue engineering. Finally, applications of polymeric nanofibers in the fields of bone, cartilage, ligament and tendon, cardiovascular, and neural tissue engineering will be reviewed.

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Section: Electrospinningmentioning

confidence: 99%

“…40,43 Molecular structure X-ray diffraction is commonly used to determine the crystal structure of polymer fibers. 15,20,42,52 Often after chemical modification or the attachment of functional groups, the molecular structure is determined using FTIR 42,43,85,86 or nuclear magnetic resonance analysis. 52 …”

Section: Drug and Protein Distributionmentioning

confidence: 99%

Polymeric Nanofibers in Tissue Engineering

Dahlin

Kasper

Mikos

2011

Tissue Engineering Part B: Reviews

293

198

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“…PVA is used for a variety of biomedical applications such as bone implants (Allen et al, 2004;, and artificial organs (Chen et al, 1994). Several researchers have developed nanofibers of PVA with chitosan by electrospinning because PVA has good fiberforming characteristics (Li & Hsieh, 2006;Zhou et al, 2006;Huang et al, 2007;Jia et al, 2007;Zhou et al, 2007). The electrospun composite chitosan/PVA nanofibers in different ratios for biomedical applications were reported (Ding et al, 2002;Koski et al, 2004;Ohkawa et al 2004;Lin et al 2006;Zhang et al 2007;Zhou et al, 2008).…”

Section: Electrospinning Of Chitosanmentioning

confidence: 99%

“…Alternatively, the addition of cationic and anionic polyelectrolytes (Son et al, 2004) would also increase the conductivity of a solution and thus decrease fiber diameter. Since chitosan is a linear cationic polymer, it was determined that the polyelectrolyte chitosan can act like other ionic additives and does reduce fiber diameter thus producing thinner, uniform, bead free fibers was noted (Lin et al, 2006;Jia et al, 2007). It was also noted by Jia et al, 2007 that the formation of a crystalline microstructure is restricted during electrospinning because the stretched molecular chains solidify rapidly and at high elongation rates.…”

Section: Electrospinning Of Chitosanmentioning

confidence: 99%

“…Since chitosan is a linear cationic polymer, it was determined that the polyelectrolyte chitosan can act like other ionic additives and does reduce fiber diameter thus producing thinner, uniform, bead free fibers was noted (Lin et al, 2006;Jia et al, 2007). It was also noted by Jia et al, 2007 that the formation of a crystalline microstructure is restricted during electrospinning because the stretched molecular chains solidify rapidly and at high elongation rates. This effect has additionally been noted elsewhere (Deitzel et al, 2001;Zong et al, 2002).…”

Section: Electrospinning Of Chitosanmentioning

confidence: 99%

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Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

Jayakumar¹,

Nair²,

Furuike³

et al. 2010

Tissue Engineering

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Chitin and its deacetylated derivative, chitosan, are non-toxic, biodegradable biopolymers currently being developed for use in biomedical applications such as tissue engineering scaffolds, wound dressings, separation membranes, antibacterial coatings, stent coatings, and sensors. Recently, nano fibrous scaffolds based on chitin or chitosan have potential applications in tissue engineering. Tissue engineering is one of the most exciting interdisciplinary and multidisciplinary research areas today, and there has been exponential growth in the number of research publications in this area in recent years. It involves the use of living cells, manipulated through their extracellular environment or genetically to develop biological substitutes for implantation into the body and/or to foster remodeling of tissues in some active manners. Electrospun chitin and chitosan nano fibrous scaffolds would be used to produce tissue engineering scaffolds with improved cytocompatibility, which could mimic the native extracellular matrix (ECM). Electrospinning is truly a feasible means of producing nano fibrous scaffolds that resemble the ECM, however, moreover than this, it is imperative that the effects of an artificial matrix has on cell growth, proliferation, and differentiation. This review summarizes the recent progress in chitin and chitosan based nano fibrous scaffolds with an emphasis in tissue engineering applications.

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