Fabrication and characterization of PLLA/Mg composite tube as the potential bioresorbable/biodegradable stent(BRS)

Srivastava, Alok; Ahuja, Ramya; Bhati, Pooja; Singh, Shweta; Chauhan, Pankaj; Vashisth, Priya; Kumar, Avinash; Bhatnagar, Naresh

doi:10.1016/j.mtla.2020.100661

Cited by 13 publications

(16 citation statements)

References 52 publications

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“…Figure 4 presents FTIR spectra of PLLA and PLLA/ZnO membranes, with the main bands belonging to polymer PLLA [33,34]. The strongest peak located at around 1754 cm −1 corresponds to the vibration of the C = O bond, while symmetric and asymmetric bending vibration of CH 3 groups were observed at 1454, 1385, and 1362 cm −1 .…”

Section: Physico-chemical Properties Of Plla/zno Composite Membranesmentioning

confidence: 99%

Structure and Properties of Biodegradable PLLA/ZnO Composite Membrane Produced via Electrospinning

et al. 2020

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These days, composite materials based on polymers and inorganic nanoparticles (NPs) are widely used in optoelectronics and biomedicine. In this work, composite membranes of polylactic acid and ZnO NPs containing 5–40 wt.% of the latter NPs were produced by means of electrospinning. For the first time, polymer material loaded with up to 40 wt.% of ZnO NPs (produced via laser ablation in air and having non-modified surface) was used to prepare fiber-based composite membranes. The morphology, phase composition, mechanical, spectral and antibacterial properties of the membranes were tested by a set of analytical techniques including SEM, XRD, FTIR, UV-vis, and photoluminescence spectroscopy. Antibacterial activity of the materials was evaluated following standard procedures (ISO 20743:2013) and using S. aureus and E. coli bacteria. It is shown that incorporation of 5–10 wt.% of NPs led to improved mechanical properties of the composite membranes, while further increase of ZnO content up to 20 wt.% and above resulted in their noticeable deterioration. At the same time, the antibacterial properties of ZnO-rich membranes were more pronounced, which is explained by a larger number of surface-exposed ZnO NPs, in addition to those embedded into the bulk of fiber material.

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Section: Physico-chemical Properties Of Plla/zno Composite Membranesmentioning

confidence: 99%

Structure and Properties of Biodegradable PLLA/ZnO Composite Membrane Produced via Electrospinning

et al. 2020

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“…And their degradation products, after being degraded in vivo are non-toxic and can be absorbed by the body or excreted with metabolism ( Brannigan and Dove, 2017 ; Xu et al, 2020 ). However, the degradation products of polyester materials can cause a decrease in the pH of the local microenvironment and are prone to cause sterile inflammation ( Srivastava et al, 2020 ). This problem also needs to be considered and solved in practical applications.…”

Section: Biodegradable Polymersmentioning

confidence: 99%

Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis

Liu

Liang

2022

Front. Bioeng. Biotechnol.

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Chronic osteomyelitis is one of the most challenging diseases in orthopedic treatment. It is usually treated with intravenous antibiotics and debridement in clinical practice, which also brings systemic drug side effects and bone defects. The local drug delivery system of antibiotics has the characteristics of targeted slow release to the lesion site, replacing systemic antibiotics and reducing the toxic and side effects of drugs. It can also increase the local drug concentration, achieve sound bacteriostatic effects, and promote bone healing and formation. Currently, PMMA beads are used in treating chronic osteomyelitis at home and abroad, but the chain beads need to be removed after a second operation, inconveniences patients. Biodegradable materials have been extensively studied as optimal options for antibiotic encapsulation and delivery, bringing new hope for treating chronic osteomyelitis. This article reviews the research progress of local drug delivery systems based on biodegradable polymers, including natural and synthetic ones, in treating chronic osteomyelitis.

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“…With this in mind, efforts have been gathered to develop a new generation of biodegradable stents, made by combining polymers and Mg properties, with improved radial strength, better ductility, controlled drug delivery, and prolonged degradation times. Most recently, a new approach consisting on bioresorbable Polymer/Mg composites has been proposed for cardiovascular applications [41].…”

Section: Cardiovascularmentioning

confidence: 99%

“…The company Biotronik (Germany) offers resorbable Mg stents for vascular intervention. [21] First attempt of Mg for osteosynthesis [22] Mg alloys in cardiovascular implant technology [39] In vivo studies (AZ31, AZ91, WE43, LAE442) [44] Review of Mg alloys as biomaterials (AZ31, AZ91, WE43) [16] Drug eluting bioresorbable Mg stent [38] Toxicity of alloying elements (rare earth, Al) [25] Binary Mg-Zn alloy coated with PLGA [29] Absorbable Metal Stent insight (WE31 alloy) [40] Polymer/Mg composites for orthopedic applications [31] Review of coatings on Mg alloys [ [41] In vivo studies Pure Mg [32] Small and large animal models (MgZnCa alloys)…”

Section: Cardiovascularmentioning

confidence: 99%

Bioresorbable Metals for Cardiovascular and Fracture Repair Implants

Cifuentes

2021

Materials Research Foundations

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The potential of bioresorbable metals to revolutionize current and future medical devices fascinates researchers. Magnesium, iron, and zinc have been thoroughly studied for the treatment of cardiovascular diseases or to repair fractures. Iron was the first type of metal being researched and introduced in biomedical applications. Magnesium is the most studied one, it has been tested by clinical trials and commercially available products have been already developed. The interest in zinc has recently emerged and is continuously growing. This chapter offers an overview of the role that Mg, Fe, and Zn are playing advancing the evolution of bioresorbable implants.

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Fabrication and characterization of PLLA/Mg composite tube as the potential bioresorbable/biodegradable stent(BRS)

Cited by 13 publications

References 52 publications

Structure and Properties of Biodegradable PLLA/ZnO Composite Membrane Produced via Electrospinning

Structure and Properties of Biodegradable PLLA/ZnO Composite Membrane Produced via Electrospinning

Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis

Bioresorbable Metals for Cardiovascular and Fracture Repair Implants

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