Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis

Liu, Yixiu; Xu, Li; Liang, Anna

doi:10.3389/fbioe.2022.1042128

Cited by 15 publications

(7 citation statements)

References 115 publications

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“…Therefore, there is an urgent clinical need for a new material that not only possesses the supportive strength, biocompatibility, and biosafety of bone cement but also offers more efficient antibacterial action and promotes bone repair. 94 , 95 …”

Section: Tissue Engineering Treatment Of Bone Infectionsmentioning

confidence: 99%

Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

Qin,

Yang,

Zhao

et al. 2024

Bone Res

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Osteomyelitis is a devastating disease caused by microbial infection in deep bone tissue. Its high recurrence rate and impaired restoration of bone deficiencies are major challenges in treatment. Microbes have evolved numerous mechanisms to effectively evade host intrinsic and adaptive immune attacks to persistently localize in the host, such as drug-resistant bacteria, biofilms, persister cells, intracellular bacteria, and small colony variants (SCVs). Moreover, microbial-mediated dysregulation of the bone immune microenvironment impedes the bone regeneration process, leading to impaired bone defect repair. Despite advances in surgical strategies and drug applications for the treatment of bone infections within the last decade, challenges remain in clinical management. The development and application of tissue engineering materials have provided new strategies for the treatment of bone infections, but a comprehensive review of their research progress is lacking. This review discusses the critical pathogenic mechanisms of microbes in the skeletal system and their immunomodulatory effects on bone regeneration, and highlights the prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections. It will inform the development and translation of antimicrobial and bone repair tissue engineering materials for the management of bone infections.

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Section: Tissue Engineering Treatment Of Bone Infectionsmentioning

confidence: 99%

Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

Qin,

Yang,

Zhao

et al. 2024

Bone Res

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“…For both surgical site infections and osteomyelitis, which are commonly caused by Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, as well as more resistant strains like Methicillin-resistant Staphylococcus aureus, up to 6 weeks of the sustained delivery of gentamicin might be needed to eliminate the infections and their biofilms [66,83,84]. Although non-biodegradable bone cements, like poly (methyl methacrylate) (PMMA), possess several advantages for osteomyelitis treatment, the need for a second surgical intervention to remove them hinders their wider use [85,86]. Biodegradable PLGA-based nanocarrier administration via injection at the site of infection is a great alternative [66].…”

Section: Gentamicin-loaded Plga Nanoparticlesmentioning

confidence: 99%

From Polymeric Nanoformulations to Polyphenols—Strategies for Enhancing the Efficacy and Drug Delivery of Gentamicin

Bārzdiņa,

Plotniece,

Sobolev

et al. 2024

Antibiotics

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Gentamicin is an essential broad-spectrum aminoglycoside antibiotic that is used in over 40 clinical conditions and has shown activity against a wide range of nosocomial, biofilm-forming, multi-drug resistant bacteria. Nevertheless, the low cellular penetration and serious side effects of gentamicin, as well as the fear of the development of antibacterial resistance, has led to a search for ways to circumvent these obstacles. This review provides an overview of the chemical and pharmacological properties of gentamicin and offers six different strategies (the isolation of specific types of gentamicin, encapsulation in polymeric nanoparticles, hydrophobization of the gentamicin molecule, and combinations of gentamicin with other antibiotics, polyphenols, and natural products) that aim to enhance the drug delivery and antibacterial activity of gentamicin. In addition, factors influencing the synthesis of gentamicin-loaded polymeric (poly (lactic-co-glycolic acid) (PLGA) and chitosan) nanoparticles and the methods used in drug release studies are discussed. Potential research directions and future perspectives for gentamicin-loaded drug delivery systems are given.

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“…Several antibacterial polymers were reported approximately 20 years ago [ 17 , 18 ]. Presently, antibacterial polymers and polymeric systems have proven to be effective against clinically relevant bacteria [ 19 , 20 ]. Hydrogels in a polymeric system can be fabricated from different polymers with inherent antibacterial activities, which in effect, confers specific antibacterial activity of the hydrogel formulation.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Periodontal Infections, the Possible Role of Hydrogels as Antibiotic Drug-Delivery Systems

et al. 2023

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With the advancement of biomedical research into antimicrobial treatments for various diseases, the source and delivery of antibiotics have attracted attention. In periodontal diseases, antibiotics are integral in positive treatment outcomes; however, the use of antibiotics is with caution as the potential for the emergence of resistant strains is of concern. Over the years, conventional routes of drug administration have been proven to be effective for the treatment of PD, yet the problem of antibiotic resistance to conventional therapies continues to remain a setback in future treatments. Hydrogels fabricated from natural and synthetic polymers have been extensively applied in biomedical sciences for the delivery of potent biological compounds. These polymeric materials either have intrinsic antibacterial properties or serve as good carriers for the delivery of antibacterial agents. The biocompatibility, low toxicity and biodegradability of some hydrogels have favoured their consideration as prospective carriers for antibacterial drug delivery in PD. This article reviews PD and its antibiotic treatment options, the role of bacteria in PD and the potential of hydrogels as antibacterial agents and for antibiotic drug delivery in PD. Finally, potential challenges and future directions of hydrogels for use in PD treatment and diagnosis are also highlighted.

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Current research progress of local drug delivery systems based on biodegradable polymers in treating chronic osteomyelitis

Cited by 15 publications

References 115 publications

Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

Prospects and challenges for the application of tissue engineering technologies in the treatment of bone infections

From Polymeric Nanoformulations to Polyphenols—Strategies for Enhancing the Efficacy and Drug Delivery of Gentamicin

Treatment of Periodontal Infections, the Possible Role of Hydrogels as Antibiotic Drug-Delivery Systems

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