Fabrication and characterization of Mg-doped chitosan–gelatin nanocompound coatings for titanium surface functionalization

Abstract

Titanium and its alloys have been widely used in clinic and achieved great success. Due to the bio-inertness of titanium surface, challenges still exit in some compromised conditions. The present study aimed to functionalize titanium surface with magnesium (Mg)-doped chitosan/gelatin (CS/G) nanocompound coatings via electrophoretic deposition (EPD). CS/G coatings loaded with different amount of magnesium were successfully prepared on titanium substrate via EPD. Physicochemical characterization of the coatings confirmed that magnesium ions were loaded into the coatings in a dose-dependent manner. XRD results demonstrated that co-deposition of magnesium influenced the crystallinity of the coatings, and a new crystalline substance presented, namely hydrated basic magnesium carbonate. Mechanical tests showed improved tensile and shear bond strength of the magnesium-doped coatings, while the excessively high magnesium concentration could eventually decrease the bonding strength. Sustained release of magnesium ion was detected by ICP-OES within 28 days. TEM images also displayed that nanoparticles could be released from the coatings. In vitro cellular response assays demonstrated that the Mg-doped nanocompound coatings could enhance the proliferation and osteogenic differentiation of MC3T3-E1 cells compared to CS/G coatings. Therefore, it could be concluded that Mg-doped CS/G nanocompound coatings were successfully fabricated on titanium substrates via EPD. It would be a promising candidate to functionalize titanium surface with such organic-inorganic nanocompound coatings.

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

“…According to the literature, there have been few attempts to co-deposit CS with various TMIs by EPD, using a simultaneous cathodic deposition. However, the results from such previous studies indicate that atomic deposition of the metallic phase and the formation of new crystalline phases occur on the electrode after EPD [10,[24][25][26][27]. In such cases metal particles physically embedded in the chitosan matrix and furthermore the addition of salts in the deposition suspension significantly effects CS electrodeposition behavior, which leads to the formation of less homogeneous and less rigid films [28,29].…”

Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review

“…Titanium dioxide coating could change the physical properties and form a micro or nanoscale rough surface structure to some extent, thereby improving the hydrophilia and osteogenic differentiation induction ability of scaffold. Its convenience allows it to be combined with other types of titanium property improvement techniques to promote osteogenesis (67,68) further. Drug/bioactive factor-related coatings are currently the most popular coating technology.…”

Facile Synthesis of Gallium (III)-Chitosan Complexes as Antibacterial Biomaterial

“…Ga (III) is reported to exert inhibitory efficiency against numerous bacteria ( S. aureus , P. aeruginosa , E. coli , A. baumannii , etc. ), as well as therapeutic activity against diverse disorders, including accelerated bone resorption, autoimmune disease, and certain cancers [ 20 , 21 , 22 , 23 ]. According to Pearson’s classification from 1967, Ga (III) ion bonds most strongly to oxygen atoms and, to a lower magnitude, with nitrogen atoms on ligands [ 20 ].…”

“…), as well as therapeutic activity against diverse disorders, including accelerated bone resorption, autoimmune disease, and certain cancers [ 20 , 21 , 22 , 23 ]. According to Pearson’s classification from 1967, Ga (III) ion bonds most strongly to oxygen atoms and, to a lower magnitude, with nitrogen atoms on ligands [ 20 ]. This behavior makes Ga a suitable candidate for complexation with CS through bonding with N and O atoms from the amino and hydroxyl groups on the polymer chain and at least one water molecule, probably forming penta- or hexacoordinative complexes similar to Fe 3+ [ 11 , 24 , 25 ].…”