Fabrication and characterization of matrine-loaded konjac glucomannan/fish gelatin composite hydrogel as antimicrobial wound dressing

Zhou, Liping; Xu, Tingwei; Yan, Jicheng; Li, Xin; Xie, Yuqing; Chen, Hao

doi:10.1016/j.foodhyd.2020.105702

Cited by 74 publications

(34 citation statements)

References 31 publications

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“…Hydrogels were formed by chemical or physical crosslinking of soluble or hydrophilic polymers. Although hydrogels had a cooling effect on the wounds, they had weak mechanical integrity when swollen, thus hybrid hydrogels had gained lots of attention in this field [ 41 ]. Konjac glucomannan hydrogel is an example of a hydrogel with swelling and gel-forming ability, that could not be adequately utilized due to flexibility and water retention limitations [ 41 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…Although hydrogels had a cooling effect on the wounds, they had weak mechanical integrity when swollen, thus hybrid hydrogels had gained lots of attention in this field [ 41 ]. Konjac glucomannan hydrogel is an example of a hydrogel with swelling and gel-forming ability, that could not be adequately utilized due to flexibility and water retention limitations [ 41 ]. Fish gelatin gels had been utilized in wound dressing due to their biocompatibility, biodegradability and low antigenicity.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…The composite gel had great water absorption and thermal stability, all of which would aid in wound healing. The combination of konjac and fish gelatin was found to be promising to overcome the drawbacks and reinforce the gel properties [ 41 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…(3) Biomedical applications, it has many intrinsic activities including antihypertensive, antidiabetic, anticancer, antioxidant, and antimicrobial activities. It is also used in wound dressing and wound healing, gene therapy and tissue engineering [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. (4) Pharmaceutical industry and drug delivery, it is widely used as a gelling agent for plasma expanders.…”

Section: Introductionmentioning

confidence: 99%

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Cosmetic, Biomedical and Pharmaceutical Applications of Fish Gelatin/Hydrolysates

et al. 2021

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There are several reviews that separately cover different aspects of fish gelatin including its preparation, characteristics, modifications, and applications. Its packaging application in food industry is extensively covered but other applications are not covered or covered alongside with those of collagen. This review is comprehensive, specific to fish gelatin/hydrolysate and cites recent research. It covers cosmetic applications, intrinsic activities, and biomedical applications in wound dressing and wound healing, gene therapy, tissue engineering, implants, and bone substitutes. It also covers its pharmaceutical applications including manufacturing of capsules, coating of microparticles/oils, coating of tablets, stabilization of emulsions and drug delivery (microspheres, nanospheres, scaffolds, microneedles, and hydrogels). The main outcomes are that fish gelatin is immunologically safe, protects from the possibility of transmission of bovine spongiform encephalopathy and foot and mouth diseases, has an economic and environmental benefits, and may be suitable for those that practice religious-based food restrictions, i.e., people of Muslim, Jewish and Hindu faiths. It has unique rheological properties, making it more suitable for certain applications than mammalian gelatins. It can be easily modified to enhance its mechanical properties. However, extensive research is still needed to characterize gelatin hydrolysates, elucidate the Structure Activity Relationship (SAR), and formulate them into dosage forms. Additionally, expansion into cosmetic applications and drug delivery is needed.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cosmetic, Biomedical and Pharmaceutical Applications of Fish Gelatin/Hydrolysates

et al. 2021

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“…Konjac/gelatin hydrogel was fabricated by alkali processing and thermal treatment and it showed excellent matrine encapsulation efficiency. Moreover, matrine-loaded konjac/gelatin hydrogel could not only maintain a physiological environment beneficial to wound healing, but also inhibit the growth of bacteria on the wound surface [ 19 ]. A novel multifunctional poly(γ-glutamic acid)/gelatin hydrogel was fabricated and confirmed to be a promising wound dressing material for the wound healing [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Antibacterial Gelatin/Sodium Alginate Sponges and Their Antibacterial Activity

Wen

Zhu

et al. 2020

Polymers

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In the present study, sponges with the antibiotic tetracycline hydrochloride (TCH) loaded into alginate incorporated with gelatin (G/SA) were fabricated. The G/SA sponges were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric (TG) analysis. G/SA sponges show a three-dimensional network structure with high porosity. An excellent swelling behavior and a controlled TCH release performance are observed from G/SA sponges. Moreover, they exhibit good antibacterial activity against both Gram-positive and Gram-negative bacteria.

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Konjac glucomannan: A review of structure, physicochemical properties, and wound dressing applications

Zhou

Zheng

Xie

et al. 2021

J of Applied Polymer Sci

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Natural bio‐based materials used in wound dressings have been continuously developed in recent years, and have certain advantages in water retention, biocompatibility, and therapeutic properties. Konjac glucomannan (KGM) is a kind of plant polysaccharide with good cell compatibility and gel properties. Various gels obtained by modification of KGM through physical and chemical methods have great application potential in wound excipients. In the past few years, various KGM‐based wound barrier materials such as hydrogels, xerogel, microspheres, films, and fibers have been continuously researched and developed. The combination of KGM and other polymers can improve the problem of poor mechanical properties and give it new functional properties, which is beneficial to the moisturizing of the wound surface and the release of drugs to promote wound healing. This article reviews the physicochemical properties of KGM and the latest developments in KGM‐based composite gels, reveals the relationship between molecules in KGM‐based composite gels, and looks forward to the research and development prospects of KGM‐based composites in wound dressings.

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Fabrication and characterization of matrine-loaded konjac glucomannan/fish gelatin composite hydrogel as antimicrobial wound dressing

Cited by 74 publications

References 31 publications

Cosmetic, Biomedical and Pharmaceutical Applications of Fish Gelatin/Hydrolysates

Cosmetic, Biomedical and Pharmaceutical Applications of Fish Gelatin/Hydrolysates

Synthesis of Antibacterial Gelatin/Sodium Alginate Sponges and Their Antibacterial Activity

Konjac glucomannan: A review of structure, physicochemical properties, and wound dressing applications

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