Fabrication and characterization of fast dissolving glycerol monolaurate microemulsion encapsulated gelatin nanofibers with antimicrobial activity

Zhang, Xinyan; Tan, Liansheng; Taxipalati, Maierhaba; Deng, Lingli

doi:10.1002/jsfa.11220

Cited by 10 publications

(2 citation statements)

References 52 publications

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“…Examples include the application of functional foods such as active substance embedding and nutrient substance encapsulation and transportation [151][152][153][154] . It is also widely used in the field of food packaging [155][156][157][158][159][160][161] , such as cheese packaging 162 , beef packaging 163 , pork preservation 164 , chicken packaging 165 , fish packaging 166,167 , and bread packaging 168 .…”

Section: Gelatinmentioning

confidence: 99%

Green electrospinning for safe food engineering

Jiang

Che³

et al. 2023

Preprint

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The nanofibers formed by electrospinning technology have the advantages of orderly release mechanism and controllable dissolution rate. However, the use of toxic and harmful organic solvents is widespread in the field of electrospinning, which not only poses a potential hazard to human health and the natural environment, but also increases the manufacturing cost and difficulty of electrospinning. Therefore, the purpose of this paper is to introduce the application of green electrospinning technology in food engineering. Water solvent electrospinning is mainly introduced, and some water-soluble biopolymer and synthetic polymers are reviewed. Their latest applications and development limitations in the field of food engineering are introduced and discussed. The water solvent electrospinning introduced here transforms a process that has adverse effects on the environment and health into a scalable and ecologically conscious “green” electrospinning, which is both important and timely and will bring exemplary changes to the field of food engineering.

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Section: Gelatinmentioning

confidence: 99%

Green electrospinning for safe food engineering

Jiang

Che³

et al. 2023

Preprint

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“…As a medium-chain fatty acid, GML not only provides energy and regulates the immunologic balance (19-21) but also kills harmful pathogens such as Salmonella (22), enterotoxic Escherichia coli (23), and Staphylococcus aureus (11,(24)(25)(26)(27)(28). Interestingly, GML had no effect on probiotics such as Lactobacillus (29)(30)(31).…”

Section: Introductionmentioning

confidence: 99%

Glycerol monolaurate ameliorates DSS-induced acute colitis by inhibiting infiltration of Th17, neutrophils, macrophages and altering the gut microbiota

Dong²,

Ouyang

et al. 2022

Front. Nutr.

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Background and aimsInflammatory bowel disease (IBD) places a heavy medical burden on countries and families due to repeated and prolonged attacks, and the incidence and prevalence of IBD are increasing worldwide. Therefore, finding an effective treatment is a matter of great urgency. Glycerol monolaurate (GML), which has a twelve-carbon chain, is a compound naturally found in human breast milk. Some studies have shown that GML has antibacterial and anti-inflammatory effects. However, the specific mechanism of action remains unclear.MethodsAcute colitis was established in mice using 3% DSS, and glycerol monolaurate (500 mg·kg−1) was administered for two weeks. QPCR and western blotting were performed to examine the inflammatory status. Mice described were subjected to flow cytometry analysis for immune cell activation.ResultsGML treated alleviated macroscopic symptoms such as shortened colons, increased spleen weight, and caused weight loss in mice with DSS-induced colitis. In addition, GML decreased the expression of pro-inflammatory factors (NF-α, IL-1β and IL-1α) and increased the expression of anti-inflammatory factors (IL-10 and TGF-β). GML inhibited the activation of the MAPK and NF-κB signalling pathways, improved tissue damage, and increased the expression of intestinal tight junction proteins. In addition, LPMCs extracted from intestinal tissue via flow cytometry showed that GML treatment led to a decrease of Th17 cells, Neutrophils and Macrophages. 16S rDNA sequencing showed that GML increased the abundance of commensal bacterium such as Akkermansia and Lactobacillus murinus.ConclusionsWe showed that oral administration of GML ameliorated DSS-induced colitis by inhibiting infiltration of Th17 cells, Neutrophils, and Macrophages, protecting the intestinal mucosal barrier and altered the abundance of commensal bacterium. This study provides new insights into the biological function and therapeutic potential of GML in the treatment of IBD.

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