Silk protein/polyvinylpyrrolidone nanofiber membranes loaded with puerarin accelerate wound healing in mice by reducing the inflammatory response

Sun, Shuwen; Ding, Chuanbo; Liu, Xinglong; Zhao, Yingchun; Zhang, Jinping; Ding, Qiteng; Zhang, Yiwen; Zhang, Yue; Hao, Mingqian; Zheng, Yi-Nan; Liu, Wencong; Yang, Min

doi:10.1016/j.bioadv.2022.212734

Cited by 17 publications

(4 citation statements)

References 47 publications

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“…Reasonable control of these factors can prolong the stability of SF. Due to its biocompatibility, adjustable degradation, unique biomedical and mechanical properties, ease of processing, and abundant supply, SF can be processed into gels [ 60 ], films [ 61 ], nanofibers [ 62 ], nanoparticles [ 63 ], and other materials that can be widely applied in drug delivery [ 64 ], tissue repair [ 65 ], and other fields.…”

Section: Biological Properties Of Sfmentioning

confidence: 99%

Evaluation and Application of Silk Fibroin Based Biomaterials to Promote Cartilage Regeneration in Osteoarthritis Therapy

et al. 2023

Biomedicines

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Osteoarthritis (OA) is a common joint disease characterized by cartilage damage and degeneration. Traditional treatments such as NSAIDs and joint replacement surgery only relieve pain and do not achieve complete cartilage regeneration. Silk fibroin (SF) biomaterials are novel materials that have been widely studied and applied to cartilage regeneration. By mimicking the fibrous structure and biological activity of collagen, SF biomaterials can promote the proliferation and differentiation of chondrocytes and contribute to the formation of new cartilage tissue. In addition, SF biomaterials have good biocompatibility and biodegradability and can be gradually absorbed and metabolized by the human body. Studies in recent years have shown that SF biomaterials have great potential in treating OA and show good clinical efficacy. Therefore, SF biomaterials are expected to be an effective treatment option for promoting cartilage regeneration and repair in patients with OA. This article provides an overview of the biological characteristics of SF, its role in bone and cartilage injuries, and its prospects in clinical applications to provide new perspectives and references for the field of bone and cartilage repair.

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Section: Biological Properties Of Sfmentioning

confidence: 99%

Evaluation and Application of Silk Fibroin Based Biomaterials to Promote Cartilage Regeneration in Osteoarthritis Therapy

et al. 2023

Biomedicines

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“…In the animal wound healing Further, thymol was added to the NFM, which made the drug-loaded NFM have good antibacterial effects against Escherichia coli and Staphylococcus aureus. Sun et al [113] prepared puerarin-loaded electrospun composite NFMs with silk protein and polyvinylpyrrolidone (PVP) as matrix materials. It has been proven that puerarin improved the porosity, hydrophilicity, and antioxidant capacity of NFMs.…”

Section: Antibacterial Factorsmentioning

confidence: 99%

Electrospun Nanofiber Membranes with Various Structures for Wound Dressing

Yang,

2023

Materials

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Electrospun nanofiber membranes (NFMs) have high porosity and a large specific surface area, which provide a suitable environment for the complex and dynamic wound healing process and a large number of sites for carrying wound healing factors. Further, the design of the nanofiber structure can imitate the structure of the human dermis, similar to the natural extracellular matrix, which better promotes the hemostasis, anti-inflammatory and healing of wounds. Therefore, it has been widely studied in the field of wound dressing. This review article overviews the development of electrospinning technology and the application of electrospun nanofibers in wound dressings. It begins with an introduction to the history, working principles, and transformation of electrospinning, with a focus on the selection of electrospun nanofiber materials, incorporation of functional therapeutic factors, and structural design of nanofibers and nanofiber membranes. Moreover, the wide application of electrospun NFMs containing therapeutic factors in wound healing is classified based on their special functions, such as hemostasis, antibacterial and cell proliferation promotion. This article also highlights the structural design of electrospun nanofibers in wound dressing, including porous structures, bead structures, core-shell structures, ordered structures, and multilayer nanofiber membrane structures. Finally, their advantages and limitations are discussed, and the challenges faced in their application for wound dressings are analyzed to promote further research in this field.

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“…9 The preparation of single-layer electrospun nanofibers by mixing drugs and materials is the most common method in wound dressing. 10 Although the preparation process is simple, there are problems such as uncontrolled drug release and the inability to drain the excessive exudate around the wound, which make it difficult to achieve multifunctional wound dressings.…”

Section: Introductionmentioning

confidence: 99%

“…Electrospun nanofibrous membranes have been recognized as a class of promising wound dressing materials for wound healing because of their high specific surface areas, porous nanostructures, and structural similarity to the native extracellular matrix (ECM), which are beneficial for cell adhesion and growth as well as transport of cellular nutrients and metabolites. , In addition, another advantage of electrospun nanofibers is that they can efficiently load and deliver drugs to the wound site . The preparation of single-layer electrospun nanofibers by mixing drugs and materials is the most common method in wound dressing . Although the preparation process is simple, there are problems such as uncontrolled drug release and the inability to drain the excessive exudate around the wound, which make it difficult to achieve multifunctional wound dressings.…”

Section: Introductionmentioning

confidence: 99%

Phase Change Material-Embedded Multifunctional Janus Nanofiber Dressing with Directional Moisture Transport, Controlled Release of Anti-Inflammatory Drugs, and Synergistic Antibacterial Properties

Liu,

Huang,

Liang

et al. 2023

ACS Appl. Mater. Interfaces

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Wound healing is a systematic and complex process that involves various intrinsic and extrinsic factors affecting different stages of wound repair. Therefore, multifunctional wound dressings that can modulate these factors to promote wound healing are in high demand. In this work, a multifunctional Janus electrospinning nanofiber dressing with antibacterial and anti-inflammatory properties, controlled release of drugs, and unidirectional water transport was prepared by depositing coaxial nanofibers on a hydrophilic poly(ε-caprolactone)@polydopamine-ε-polyl-lysine (PCL@PDA-ε-PL) nanofiber membrane. The coaxial nanofiber was loaded with the phase change material lauric acid (LA) in the shell layer and anti-inflammatory ibuprofen (IBU) in the core layer. Among them, LA with a melting point of 43 °C served as a phase change material to control the release of IBU. The phase transition of LA was induced by near-infrared (NIR) irradiation that triggered the photothermal properties of PDA. Moreover, the Janus nanofiber dressing exhibited synergistic antimicrobial properties for Escherichia coli and Staphylococcus aureus due to the photothermal properties of PDA and antibacterial ε-PL. The prepared Janus nanofiber dressing also exhibited anti-inflammatory activity and biocompatibility. In addition, the Janus nanofiber dressing had asymmetric wettability that enabled directional water transport, thereby draining excessive wound exudate. The water vapor transmission test indicated that the Janus nanofiber dressing had good air permeability. Finally, skin wound healing evaluation in rats confirmed its efficacy in promoting wound healing. Therefore, this strategy of designing and manufacturing a multifunctional Janus nanofiber dressing had great potential in wound healing applications.

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Silk protein/polyvinylpyrrolidone nanofiber membranes loaded with puerarin accelerate wound healing in mice by reducing the inflammatory response

Cited by 17 publications

References 47 publications

Evaluation and Application of Silk Fibroin Based Biomaterials to Promote Cartilage Regeneration in Osteoarthritis Therapy

Evaluation and Application of Silk Fibroin Based Biomaterials to Promote Cartilage Regeneration in Osteoarthritis Therapy

Electrospun Nanofiber Membranes with Various Structures for Wound Dressing

Phase Change Material-Embedded Multifunctional Janus Nanofiber Dressing with Directional Moisture Transport, Controlled Release of Anti-Inflammatory Drugs, and Synergistic Antibacterial Properties

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