Fabrication and characterization of electrospun poly‐DL‐lactide (PDLLA) fibrous coatings on 45S5 Bioglass^® substrates for bone tissue engineering applications

Abstract

BACKGROUND: This work focuses on combining electrospun biodegradable poly-DL-lactide (PDLLA) fibres and 45S5 Bioglass  for tissue engineering applications.

Stratified scaffolds for osteochondral tissue engineering applications: Electrospun PDLLA nanofibre coated Bioglass®-derived foams

“…The surface roughness increased more than 13 times in terms of the rms value for 2D Bioglass Õ sintered pellets coated with PDLLA fibers. 27 This result is in agreement with the study by Chen et al 34 who modified the surface of poly(e-caprolactone) membranes via electrospinning. Topography (roughness) of the porous bilayered scaffolds could not be measured by white light interferometry because the surface is not flat.…”

“…This result was expected based on the evidence presented previously, 27 indicating the mineralization of PDLLA fibers on sintered Bioglass Õ substrates upon immersion in SBF. Figure 8(A)-(C) show SEM images of PDLLA fibers on Bioglass Õ scaffolds deposited for 30 min after immersion in SBF for 7, 14, and 28 days.…”

“…This pattern was formed due to the structure of the underlying porous scaffolds and it was not observed in fiber depositions on planar surfaces, described in the previous investigation. 27 Figure 4(A) shows a SEM image of the interface in a PDLLA/45S5 Bioglass Õ scaffold deposited for 2 h, where it is possible to observe the two distinct porous layers. Figure 4(B) shows the PDLLA fibrous layer at higher magnification.…”

“…In the present paper, results are presented, in which novel bilayered scaffolds based on Bioglass Õ derived foams (for the bone aspect) coated with a fibrous PDLLA layer obtained by electrospinning (for cartilage) have been developed and preliminary in vitro tests utilized to characterize the material. This work evolved from our previous study in which we presented the process of electrospinning of PDLLA fibers on dense bioactive glass substrates 27 and shows for the first time the formation of tissue engineering scaffolds combining electrospun PDLLA nanofibers and bioactive glass-ceramic highly porous scaffolds.…”

pH-dependent antibacterial effects on oral microorganisms through pure PLGA implants and composites with nanosized bioactive glass

“…Usually, the electrospinning solution was obtained by mixing a solgel precursor of BG with a polymer solution. Bretcanu et al and Yunos et al electrospun their polymer onto BG45S5 pellets [35,36], while in this study the BG45S5/PLGA composite was prepared by electrospinning a dispersion of the inorganic phase in the polymer solution.…”