Stratified scaffolds for osteochondral tissue engineering applications: Electrospun PDLLA nanofibre coated Bioglass®-derived foams

Yunos, D. Mohammad; Ahmad, Zeeshan; Salih, Vehid; Boccaccini, A. R.

doi:10.1177/0885328211414941

Cited by 58 publications

(37 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inspired by these multi-tissue structures, a variety of complex scaffold designs seeking to recapitulate the native spatial and compositional inhomogeneity have been developed. 4,28,77 This review will discuss current regenerative engineering efforts in ligament-bone, 3,11,19,20,54,62,68,71,72,86,87,96–98,110,111,113–115 tendon-bone, 24,78,79,137 muscle-tendon, 57,58,60,117,118 and cartilage-bone integration, 1,5,13,15–18,25–27,30,32,33,36,37,39,41,47,49,52,53,55,56,69,74,91,95,100–104,106,119,128,133–136 focusing on biomaterial- and cell-based strategies for engineering biomimetic, functional spatial variations in composition and mechanical properties. In light of the complexity of multi-tissue regeneration, the application of strategic biomimicry across tissue-tissue junctions, or prioritizing what needs to be recapitulated from native tissues and identifying the most crucial parameters for complex scaffold design, is essential for avoiding over-engineering the scaffold system.…”

Section: Introductionmentioning

confidence: 99%

Engineering Complex Orthopaedic Tissues Via Strategic Biomimicry

Mosher

Boushell

et al. 2014

Ann Biomed Eng

View full text Add to dashboard Cite

The primary current challenge in regenerative engineering resides in the simultaneous formation of more than one type of tissue, as well as their functional assembly into complex tissues or organ systems. Tissue-tissue synchrony is especially important in the musculoskeletal system, whereby overall organ function is enabled by the seamless integration of bone with soft tissues such as ligament, tendon, or cartilage, as well as the integration of muscle with tendon. Therefore, in lieu of a traditional single-tissue system (e.g. bone, ligament), composite tissue scaffold designs for the regeneration of functional connective tissue units (e.g. bone-ligament-bone) are being actively investigated. Closely related is the effort to re-establish tissue-tissue interfaces, which is essential for joining these tissue building blocks and facilitating host integration. Much of the research at the forefront of the field has centered on bioinspired stratified or gradient scaffold designs which aim to recapitulate the structural and compositional inhomogeneity inherent across distinct tissue regions. As such, given the complexity of these musculoskeletal tissue units, the key question is how to identify the most relevant parameters for recapitulating the native structure-function relationships in the scaffold design. Therefore, the focus of this review, in addition to presenting the state-of-the-art in complex scaffold design, is to explore how strategic biomimicry can be applied in engineering tissue connectivity. The objective of strategic biomimicry is to avoid over-engineering by establishing what needs to be learned from nature and defining the essential matrix characteristics that must be reproduced in scaffold design. Application of this engineering strategy for the regeneration of the most common musculoskeletal tissue units (e.g. bone-ligament-bone, muscle-tendon-bone, cartilage-bone) will be discussed in this review. It is anticipated that these exciting efforts will enable integrative and functional repair of soft tissue injuries, and moreover, lay the foundation for the development of composite tissue systems and ultimately, total limb or joint regeneration.

show abstract

Section: Introductionmentioning

confidence: 99%

Engineering Complex Orthopaedic Tissues Via Strategic Biomimicry

Mosher

Boushell

et al. 2014

Ann Biomed Eng

View full text Add to dashboard Cite

show abstract

“…Bilayered scaffolds allow for establishment of optimised tissue-specifi c biological environments in each layer. Furthermore, they can be designed to mimic the native ECM for each tissue type, which may be more suitable than the fabrication of monolithic constructs with different functional requirements of both bone and cartilage in a single structure [112] .…”

Section: Bioceramic-based Scaffolds For Osteochondral Repairmentioning

confidence: 99%

Cartilage tissue engineering

Salih

2014

Tissue Engineering Using Ceramics and Polymers

View full text Add to dashboard Cite

“…HAp nucleation has also been performed on PCL (Li et al , 2009 ;Nirmala et al , 2010 ;Samavedi et al , 2011 ) and poly(d,l-lactide) (PDLLA) (Yunos et al , 2011 ;Zou et al , 2012 ). Li et al .…”

Section: Hydroxyapatite (Hap) Nanoparticlesmentioning

confidence: 99%

“…As previously described, several studies have incorporated synthetic nanofi bers with mineral-based nanoparticles, where the fi bers were electrospun PCL, PLGA, or PDLLA (Erisken et al , 2008(Erisken et al , , 2010(Erisken et al , , 2011Li et al , 2009 ;Nirmala et al , 2010 ;Samavedi et al , 2011 ;Yunos et al , 2011 ;Ramalingam et al , 2012 ). Other electrospun interfacial constructs incorporate only the synthetic nanofi ber itself (Spalazzi et al , 2008 ;Xie et al , 2010 ;Liu et al , © Woodhead Publishing Limited, 2013 2011 ).…”

Section: Synthetic Nanofi Bersmentioning

confidence: 99%