“…While width ratio, β, limits the minimum of channel width, w w , to 5 µm according to flexure width done by Chan et al (2006). Current micromachining and etching limitation do surpass 5 µm but it is prone to defect such as scalloping and researches were mostly focused on microchannel or trench dimension rather than its wall (Kiihamäki & Franssila, 1999;Chan et al, 2006;Chen et al, 2007;Lindroos et al (2010); Lips & Puers, 2016;Tang et al, 2018). The lower and upper limits of the design variables are the maximum and minimum size for channel width, w c , and wall width, w w , for the microchannels with a constant channel height, H c. Utilizing MOPSO optimization, aspect ratio, α, and width ratio, β, adhere to the main equation of particle swarm as follows,…”