Fabrication and characterization of dextran/nanocrystalline β-tricalcium phosphate nanocomposite hydrogel scaffolds

Ghaffari, Rahil; Salimi-Kenari, Hamed; Fahimipour, Farahnaz; Rabiee, Sayed Mahmood; Adeli, Hassan; Dashtimoghadam, Erfan

doi:10.1016/j.ijbiomac.2020.01.112

Cited by 48 publications

(10 citation statements)

References 53 publications

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“…The composite hydrogel without cross‐linkers will not be able to maintain structural integrity and functions at the defect sites 5,6 . Therefore, chemical crosslinking agents such as glutaraldehyde and epichlorohydrin have been applied together with a freeze‐drying process to improve the mechanical strength and enhance the physical stability of the hydrogels 7,8 . The crosslinking process enables the hydrogels to function as scaffolds in order to maintain space and facilitate tissue formation 5,9 .…”

Section: Introductionmentioning

confidence: 99%

“…Inorganic materials act as nucleation sites for mineralization and cell adhesion that facilitate integration of the newly formed bone with the surrounding bone 20 . In addition, bioceramic nanoparticles increase the compressive strength, protein absorption, and osteoconductive properties of the hydrogels 8,18,19,4 . Therefore, it is hypothesized that bTCP improves the physical, mechanical, and sustained release properties of the thermosensitive bTCP‐bGP‐chitosan/collagen hydrogel as scaffolds and delivery vehicles of natural flavonoids for bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

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Effects of beta‐tricalcium phosphate nanoparticles on the properties of a thermosensitive chitosan/collagen hydrogel and controlled release of quercetin

Sareethammanuwat

Boonyuen

Arpornmaeklong

2020

J Biomedical Materials Res

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In the present study, an inorganic matrix of beta‐tricalcium phosphate (bTCP) nanoparticles and quercetin was incorporated into an organic matrix of 2:1 (w/w) chitosan/collagen composite to fabricate thermosensitive bTCP‐chitosan/collagen‐quercetin hydrogels. A sol–gel transition of the hydrogels was stimulated by beta‐glycerophosphate (bGP) and temperature changes at physiological temperature and pH levels. Thereafter, the effects of 1%–3% (w/v) bTCP on properties of the bTCP‐bGP‐2:1 (w/w) chitosan/collagen hydrogels were investigated. Notably, the incorporation of 1%–3% (w/v) bTCP in the hydrogels did not interfere with the gelation process and time of the hydrogels at physiological temperature and pH levels. The bTCP‐hydrogels exhibited a porous structure, interconnecting pore architecture, and median pore size of 100–200 μm. The incorporation of 3% bTCP increased the mechanical strength but decreased the swelling and degradation rates, pore size, permeability, and quercetin release rate of the hydrogels. The hydrogels were noncytotoxic and able to support cell encapsulation. A sustained quercetin release profile of the 3% bTCP‐hydrogel further suggested the applicability of the hydrogel as a delivery vehicle of natural flavonoids for bone regeneration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of beta‐tricalcium phosphate nanoparticles on the properties of a thermosensitive chitosan/collagen hydrogel and controlled release of quercetin

Sareethammanuwat

Boonyuen

Arpornmaeklong

2020

J Biomedical Materials Res

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“…For example, peptides were attached to a methacrylated dextran for regenerating axonal cells [ 62 ] and an interpenetrated polymer network (IPN) alginate-methacrylated dextran was loaded with bovine serum albumin (BSA) and chondrocytes for soft tissue engineering [ 67 ]. β-tricalciumphosphate has also been loaded in a dextran-based hydrogel, and provided an osteoinductive response according to the bioactivity results [ 68 ]. However, the poor mechanical properties of this material hinder its use for bone engineering, and another target application has been considered, namely maxillofacial reconstruction [ 68 ].…”

Section: Exopolysaccharides For Producing Ddssmentioning

confidence: 99%

“…β-tricalciumphosphate has also been loaded in a dextran-based hydrogel, and provided an osteoinductive response according to the bioactivity results [ 68 ]. However, the poor mechanical properties of this material hinder its use for bone engineering, and another target application has been considered, namely maxillofacial reconstruction [ 68 ]. These articles show the potential use of dextran hydrogels in soft tissue engineering applications, providing the mechanical properties are appropriate.…”

Section: Exopolysaccharides For Producing Ddssmentioning

confidence: 99%

Microbial Exopolysaccharides as Drug Carriers

Cardea

2020

Polymers

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Microbial exopolysaccharides are peculiar polymers that are produced by living organisms and protect them against environmental factors. These polymers are industrially recovered from the medium culture after performing a fermentative process. These materials are biocompatible and biodegradable, possessing specific and beneficial properties for biomedical drug delivery systems. They can have antitumor activity, they can produce hydrogels with different characteristics due to their molecular structure and functional groups, and they can even produce nanoparticles via a self-assembly phenomenon. This review studies the potential use of exopolysaccharides as carriers for drug delivery systems, covering their versatility and their vast possibilities to produce particles, fibers, scaffolds, hydrogels, and aerogels with different strategies and methodologies. Moreover, the main properties of exopolysaccharides are explained, providing information to achieve an adequate carrier selection depending on the final application.

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“…For applications requiring further control of the functional release and active surfaces, various coatings can be added to the hydrogel scaffold, as has been shown previously. Depending on the surface modification, [55][56][57] sensor functionality, [58] drug release, [21] and stimulation cell growth functions [21,41,59] can also be realized.…”

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confidence: 99%

Meshes‐to‐Fibrils Transition of Gellan Gum Hydrogel Architecture by Thermal Annealing

Abalymov

Meeren

Walle

et al. 2020

Macro Materials & Eng

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The possibilities created by tuning the architecture of hydrogels open up extensive opportunities for their application in tissue engineering and biomedicine. A simple and effective procedure is developed here, based on thermal annealing, which affects the alignment of the fibrils and results in a mesh‐like structure. Atomic force microscopy and cryo‐scanning electron microscopy are used to characterize the resultant gel. The alignment angle is demonstrated to take place spontaneously, providing an easy way for self‐assembly of such structures. The protocol developed here is likely to be applicable in numerous areas of biomedicine and tissue engineering.

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Fabrication and characterization of dextran/nanocrystalline β-tricalcium phosphate nanocomposite hydrogel scaffolds

Cited by 48 publications

References 53 publications

Effects of beta‐tricalcium phosphate nanoparticles on the properties of a thermosensitive chitosan/collagen hydrogel and controlled release of quercetin

Effects of beta‐tricalcium phosphate nanoparticles on the properties of a thermosensitive chitosan/collagen hydrogel and controlled release of quercetin

Microbial Exopolysaccharides as Drug Carriers

Meshes‐to‐Fibrils Transition of Gellan Gum Hydrogel Architecture by Thermal Annealing

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