Fabrication and Characterization of Buccal Film Loaded Self-emulsifying Drug Delivery System containing Lysiphyllum strychnifolium Stem Extracts

Pichayakorn, Wiwat; Monton, Chaowalit; Sampaopan, Yupaporn; Panrat, Kamon; Suksaeree, Jirapornchai

doi:10.1208/s12249-022-02341-6

Cited by 10 publications

(6 citation statements)

References 63 publications

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“…A film sample's ability to maintain a certain number of folds before breaking was investigated. The number of folds a film sample could withstand before cracking was used to calculate its folding endurance [19,20].…”

Section: Folding Endurancementioning

confidence: 99%

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Monton

Suksaeree

2023

Trends Sci

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With the guidance of Design-Expert® software version 11, the mechanical properties of topical films containing Ganoderma applanatum (G. applanatum) extracts were investigated. While ethyl cellulose (EC), G. applanatum extracts, and triethyl citrate (TEC) were independent factors, ultimate tensile strength (UTS), elongation at break, and folding endurance were dependent variables. The best relationships between UTS, elongation at break, and folding endurance could be predicted more accurately using quadratic, 2FI, and linear models, respectively. The ratio of EC, G. applanatum extracts, and TEC was predicted by the Design of Experiments (DoE) to be 2.6: 2.8: 2.8. The model’s suitability for predicting outcomes inside the design space without necessitating extra trials was established by proving that the ratio’s value of prediction was more than 4. The experimental values of UTS, elongation at break, and folding endurance were 82.15±7.42 MPa, 87.40±15.56 %, and 79±6 folds, respectively. The percent errors of prediction were 12.27, 15.49, and 11.82 %, respectively. The Design-Expert® software’s DoE effectively demonstrated a low percent error of the prediction of less than 20 %. This was suitable and acceptable for developing film formulation in drug delivery systems. HIGHLIGHTS The formulations of topical films containing applanatum extract were optimized, and they were improved EC and TEC were used as polymer matrix and plasticizer, respectively The best relationships between UTS, elongation at break, and folding endurance could be predicted more accurately using quadratic, 2FI, and linear models, respectively UTS, elongation at break, and folding endurance experimental values were 82.15±7.42 MPa, 87.40±15.56 %, and 79±6 folds Less than 20 % was effectively proven which was enough and acceptable GRAPHICAL ABSTRACT

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Section: Folding Endurancementioning

confidence: 99%

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Monton

Suksaeree

2023

Trends Sci

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“…blank film through its main semi-crystalline characteristics (Figure 12b). Strong intramolecular and intermolecular hydrogen connections exist between PVA and the main chain because of the OH groups' binding to the major chain [24,25]. In this study, because the silver-nanoparticle-complexed G. applanatum was present in significantly lower amounts than the blank film in the topical film, the topical film showed a semicrystalline structure that was more closely related to the characteristics of the blank film (Figure 12c).…”

Section: Tgamentioning

confidence: 64%

“…Folding the film sample repeatedly in the same area until it broke was used to test its folding endurance. The folding endurance was determined by counting the number of folds carried out before the film sample broke [24,25]. FTIR Spectrum FTIR spectrometer (Vertex70, Bruker, Berlin, Germany) was used to examine the sample.…”

Section: G Applanatum Folding Endurancementioning

confidence: 99%

Effect of Ionic Liquid on Silver-Nanoparticle-Complexed Ganoderma applanatum and Its Topical Film Formulation

et al. 2023

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Imidazolium-based ionic liquids have been widely utilized as versatile solvents for metal nanoparticle preparation. Silver nanoparticles and Ganoderma applanatum have displayed potent antimicrobial activities. This work aimed to study the effect of 1-butyl-3-methylimidazolium bromide-based ionic liquid on the silver-nanoparticle-complexed G. applanatum and its topical film. The ratio and conditions for preparation were optimized by the design of the experiments. The optimal ratio was silver nanoparticles: G. applanatum extract: ionic liquid at 97:1:2, and the conditions were 80 °C for 1 h. The prediction was corrected with a low percentage error. The optimized formula was loaded into a topical film made of polyvinyl alcohol and Eudragit®, and its properties were evaluated. The topical film was uniform, smooth, and compact and had other desired characteristics. The topical film was able to control the release of silver-nanoparticle-complexed G. applanatum from the matrix layer. Higuchi’s model was used to fit the kinetic of the release. The skin permeability of the silver-nanoparticle-complexed G. applanatum was improved by about 1.7 times by the ionic liquid, which might increase solubility. The produced film is suitable for topical applications and may be utilized in the development of potential future therapeutic agents for the treatment of diseases.

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“…The film proved to have very good mucoadhesion and a long release period of viable lactobacilli either at the level of a lesion at the oral mucosa or at the level of the entire oral cavity [78]. To achieve better discharge of active substances, mucoadhesive systems have been improved with solid dispersion of nanoparticles, microemulsions, and liposomes [79][80][81][82][83].…”

Section: Intraoral Mucoadhesive Systemsmentioning

confidence: 99%

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

Cocoș,

Dumitriu Buzia,

Tatu

et al. 2024

Pharmaceutics

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In this study, we focused on innovative approaches to improve drug administration in oral pathology, especially by transmucosal and transdermal pathways. These improvements refer to the type of microneedles used (proposing needles in the saw), to the use of certain enhancers such as essential oils (which, besides the amplifier action, also have intrinsic actions on oral health), to associations of active substances with synergistic action, as well as the use of copolymeric membranes, cemented directly on the tooth. We also propose a review of the principles of release at the level of the oral mucosa and of the main release systems used in oral pathology. Controlled failure systems applicable in oral pathology include the following: fast dissolving films, mucoadhesive tablets, hydrogels, intraoral mucoadhesive films, composite wafers, and smart drugs. The novelty elements brought by this paper refer to the possibilities of optimizing the localized drug delivery system in osteoarthritis of the temporomandibular joint, neuropathic pain, oral cancer, periodontitis, and pericoronitis, as well as in maintaining oral health. We would like to mention the possibility of incorporating natural products into the controlled failure systems used in oral pathology, paying special attention to essential oils.

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Fabrication and Characterization of Buccal Film Loaded Self-emulsifying Drug Delivery System containing Lysiphyllum strychnifolium Stem Extracts

Cited by 10 publications

References 63 publications

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Modelling Mechanical Properties of Topical Films Containing Ganoderma applanatum using the Design of Experiments

Effect of Ionic Liquid on Silver-Nanoparticle-Complexed Ganoderma applanatum and Its Topical Film Formulation

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

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