Fabrication and characterization of a 3D scaffold based on elastomeric poly-glycerol Sebacate polymer for heart valve applications

Preclinical in vivo assessment of a cell-free multi-layered scaffold prepared by 3D printing and electrospinning for small-diameter blood vessel tissue engineering in a canine model

“…23 The nanostructured surface and nanometer-scale roughness were found to improve EC adhesion and growth. 24,25 Previously, we found that PCL nanofibers forming the innermost layer of a three-layered scaffold can simultaneously inhibit early thrombus formation and accelerate endothelialization compared to commercial ePTFE grafts. 9 Therefore, in this study, a hierarchical structure was designed for the inner layers of the graft, in which nanofibers cover the gaps between spiral pitches, reducing the early thrombus formation due to the direct contact of blood cells with nanofibers on one hand, and providing a more convenient substrate for adhesion and proliferation of ECs on the other hand.…”

Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

“…Moreover, the advancement of 3D elastomer scaffolds has shown considerable promise, addressing the limitations of thickness and porosity found in patch materials. 374 You et al successfully integrated cross-linked DBE with thermoplastics to fabricate cardiac scaffolds with finely tuned mechanical properties and intricate micro-architectures. 181 Following a 28-day implantation period in a biological model, the PGS–PCL scaffold group exhibited a significant reduction in infarct size compared to myocardial infarction controls.…”

Aortic Valve Engineering Advancements: Precision Tuning with Laser Sintering Additive Manufacturing of TPU/TPE Submillimeter Membranes

“…These include difficulties separating the polymeric heart valve structure from the mold, particularly with thin leaflets, the possibility of air microbubble insertion if speed settings are incorrect, and the critical challenge of rapidly cooling molten polymers. For instance, Atari et al produced 3D valve scaffolds using molding and based on an elastomeric poly-glycerol sebacate polymer, which required a cusp thickness of 1.2 mm [45].…”

“…Various polymers have been explored for this purpose: elastomeric poly-glycerol sebacate polymer, poly E-caprolactone [45], polystyrene-block-isobutylene-blockstyrene [59], and polyurethane copolymers [23].…”

“…Uniaxial tensile strength of TPU samples of 0.5 mm thickness according to exposure parameters, spatial orientations(45 …”