Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Jia, Ben; Huang, Heyuan; Dong, Zhicheng; Ren, Xiaoyang; Lu, Yanyan; Wang, Wenzhi; Zhou, Shaowen; Zhao, Xin; Guo, Baolin

doi:10.1039/d3cs00923h

Cited by 11 publications

(1 citation statement)

References 401 publications

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“…In recent years, with the growing emphasis on environmental protection, polymer chemistry is moving towards sustainability, which includes the development of environmentally friendly production processes and the use of renewable feedstocks instead of fossil fuel sources [28][29][30][31]. Various research teams are already working on preparing novel raw materials from renewable sources and using them to produce new materials [32].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Graft Copolymers with Poly(ε-caprolactone) Side Chain Using Hydroxylated Poly(β-myrcene-co-α-methyl styrene)

Li,

Zhang,

et al. 2024

Molecules

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Graft copolymers have unique application scenarios in the field of high-performance thermoplastic elastomers, resins and rubbers. β-myrcene (My) is a biomass monomer derived from renewable plant resources, and its homopolymer has a low glass transition temperature and high elasticity. In this work, a series of tapered copolymers P(My-co-AMS)k (k = 1, 2, 3) were first synthesized in cyclohexane by one-pot anionic polymerization of My and α-methyl styrene (AMS) using sec-BuLi as the initiator. PAMS chain would fracture when heated at high temperature and could endow the copolymer with thermal degradation property. The effect of the incorporation of AMS unit on the thermal stability and glass transition temperature of polymyrcene main chain was studied. Subsequently, the double bonds in the linear copolymers were partially epoxidized and hydroxylated into hydroxyl groups to obtain hydroxylated copolymer, which was finally used to initiate the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) to synthesize the graft copolymer with PCL as the side chain. All these copolymers before and after modifications were characterized by proton nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), thermogravimetry analysis (TGA), and differential scanning calorimeter (DSC).

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Graft Copolymers with Poly(ε-caprolactone) Side Chain Using Hydroxylated Poly(β-myrcene-co-α-methyl styrene)

Li,

Zhang,

et al. 2024

Molecules

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Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations

Xu,

Yan,

Gerhard

et al. 2024

Advanced Materials

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Citrate‐based biodegradable polymers have emerged as a distinctive biomaterial platform with tremendous potential for diverse medical applications. By harnessing their versatile chemistry, these polymers exhibit a wide range of material and bioactive properties, enabling them to regulate cell metabolism and stem cell differentiation through energy metabolism, metabonegenesis, angiogenesis and immunomodulation. Moreover, the recent U.S. Food and Drug Administration (FDA) clearance of the biodegradable poly(octamethylene citrate) (POC)/hydroxyapatite‐based orthopedic fixation devices represent a translational research milestone for biomaterial science. POC joins a short list of biodegradable synthetic polymers that have ever been authorized by the FDA for use in humans. The clinical success of POC has sparked enthusiasm and accelerated the development of next‐generation citrate‐based biomaterials. This review presents a comprehensive, forward‐thinking discussion on the pivotal role of citrate chemistry and metabolism in various tissue regeneration and on the development of functional citrate‐based metabotissugenic biomaterials for regenerative engineering applications.This article is protected by copyright. All rights reserved

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Thermal‐Mechanical Coupling Performance of Heat‐Resistant, High‐Strength and Printable Al‐Si Alloy Antisymmetric Lattice Structure

Yan,

Dong,

Jia

et al. 2024

Advanced Science

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The unsatisfactory mechanical performance at high temperatures limits the broad application of 3D‐printed aluminum alloy structures in extreme environments. This study investigates the mechanical behavior of 4 different lattice cell structures in high‐temperature environments using AlSi12Fe2.5Ni3Mn4, a newly developed, heat‐resistant, high‐strength, and printable alloy. A novel Antisymmetric anti‐Buckling Lattice Cell (ASLC‐B) based on a unique rotation reflection multistage design is developed. Micro‐CT (Computed Tomography) and SEM (Scanning Electron Microscope) analyses revealed a smooth surface and dense interior with an average porosity of less than 0.454%. Quasi‐static compression tests at 25, 100, and 200 °C showed that ASLC‐B outperformed the other 3 lattice types in load‐bearing capacity, energy absorption, and heat transfer efficiency. Specifically, the ASLC‐B demonstrated a 51.56% and 44.14% increase in compression load‐bearing capacity at 100 and 200 °C compared to ASLC‐B(AlSi10Mg), highlighting its excellent high‐temperature mechanical properties. A numerical model based on the Johnson‐Cook constitutive relationship revealed the damage failure mechanisms, showing ASLC‐B's effectiveness in preventing buckling, enhancing load‐transfer efficiency, and reducing stress concentrations. This study emphasizes the importance of improving energy absorption and mechanical performance for structural optimization in extreme conditions. The ASLC‐B design offers significant advancements in maintaining structural integrity and performance under high temperatures.

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Degradable biomedical elastomers: paving the future of tissue repair and regenerative medicine

Abstract: This review critically analyzes degradable biomedical elastomers, focusing on their degradation, synthesis, microstructure, and role in tissue repair. It guides experts in balancing degradation with tissue repair for improved applications.

Cited by 11 publications

References 401 publications

Synthesis and Characterization of Graft Copolymers with Poly(ε-caprolactone) Side Chain Using Hydroxylated Poly(β-myrcene-co-α-methyl styrene)

Synthesis and Characterization of Graft Copolymers with Poly(ε-caprolactone) Side Chain Using Hydroxylated Poly(β-myrcene-co-α-methyl styrene)

Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations

Thermal‐Mechanical Coupling Performance of Heat‐Resistant, High‐Strength and Printable Al‐Si Alloy Antisymmetric Lattice Structure

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