Fabrication and characterization of a microporous polymeric micro-filter for isolation of<i>Cryptosporidium parvum</i>oocysts

Warkiani, Majid Ebrahimi; Lou, Chao-Ping; Gong, Haiqing

doi:10.1088/0960-1317/21/3/035002

Cited by 21 publications

(22 citation statements)

References 21 publications

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“…The SEM images of the integrated back-support and through-hole membrane are also shown in close-ups Fig. 4 Reciprocal value of rupture pressure for the metallic microfabricated membranes with different thickness in comparison to the theoretical values calculated using Rijn's model membrane pore size and thus distribution of the pores (Kovács et al 2007;Warkiani et al 2011b). …”

Section: Membrane Strengthmentioning

confidence: 93%

A high-flux isopore micro-fabricated membrane for effective concentration and recovering of waterborne pathogens

Warkiani

Lou

Liu

et al. 2012

Biomed Microdevices

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Section: Membrane Strengthmentioning

confidence: 93%

A high-flux isopore micro-fabricated membrane for effective concentration and recovering of waterborne pathogens

Warkiani

Lou

Liu

et al. 2012

Biomed Microdevices

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“…The pedicel layer, which is another filtration barrier layer, acts as a supporting structure providing mechanical strength to support the filtration barriers. Inspired by such a remarkable ability of selective filtration of the glomerular capillaries, nanoporous membranes or nanostencils for selective mass transport have recently been explored for the separation, detection, and purification of biomolecules . For the functionality of these artificial nanoporous stencils, an additional microsized structure plays a role in mechanically supporting a free‐standing, porous nanomembrane, offering a highly selective transport property.…”

Section: The Role Of Multiscale Hierarchical Structures In Naturementioning

confidence: 99%

25th Anniversary Article: Scalable Multiscale Patterned Structures Inspired by Nature: the Role of Hierarchy

et al. 2013

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Multiscale, hierarchically patterned surfaces, such as lotus leaves, butterfly wings, adhesion pads of gecko lizards are abundantly found in nature, where microstructures are usually used to strengthen the mechanical stability while nanostructures offer the main functionality, i.e., wettability, structural color, or dry adhesion. To emulate such hierarchical structures in nature, multiscale, multilevel patterning has been extensively utilized for the last few decades towards various applications ranging from wetting control, structural colors, to tissue scaffolds. In this review, we highlight recent advances in scalable multiscale patterning to bring about improved functions that can even surpass those found in nature, with particular focus on the analogy between natural and synthetic architectures in terms of the role of different length scales. This review is organized into four sections. First, the role and importance of multiscale, hierarchical structures is described with four representative examples. Second, recent achievements in multiscale patterning are introduced with their strengths and weaknesses. Third, four application areas of wetting control, dry adhesives, selectively filtrating membranes, and multiscale tissue scaffolds are overviewed by stressing out how and why multiscale structures need to be incorporated to carry out their performances. Finally, we present future directions and challenges for scalable, multiscale patterned surfaces.

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“…Only a couple of other polymers have been reportedly used for membrane fabrication by lithography. Among the few examples are epoxy-based photoresists (e. g. SU-8) 18,19 , also frequently applied in the electronic industry for other purposes and polydimethylsiloxane (PDMS) [20][21][22] . Huh et al 20 first demonstrated the fabrication of controllable PDMS microporous membrane having better porosity along with larger active area (1 × 2 cm) than previous reports, effective for the chosen application, but still smaller than what would be needed for most filtration purposes.…”

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confidence: 99%

Nanofabrication of Isoporous Membranes for Cell Fractionation

Sabirova

Pisig

Rayapuram

et al. 2020

Sci Rep

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cell fractionations and other biological separations frequently require several steps. they could be much more effectively done by filtration, if isoporous membranes would be available with high pore density, and sharp pore size distribution in the micro-and nanoscale. We propose a combination of two scalable methods, photolithography and dry reactive ion etching, to fabricate a series of polyester membranes with isopores of size 0.7 to 50 μm and high pore density with a demonstrated total area of 38.5 cm 2 . The membranes have pore sizes in the micro-and submicro-range, and pore density 10-fold higher than track-etched analogues, which are the only commercially available isoporous polymeric films. Permeances of 220,000 L m −2 h −1 bar −1 were measured with pore size 787 nm. The method does not require organic solvents and can be applied to many homopolymeric materials. the pore reduction from 2 to 0.7 μm was obtained by adding a step of chemical vapor deposition. The isoporous system was successfully demonstrated for the organelle fractionation of Arabidopsis homogenates and could be potentially extended to other biological fractionations.Different biomedical and diagnostic technologies, such as cancer cell separation, biosensing, controlled drug delivery, microfluidic devices for organ-in-a-chip, as well as investigations in plant and bioscience relay on effective separation processes. The main hurdle for an effective separation by filtration is the limited availability of highly uniform pores in the size of tens to a few micrometers, a range relevant for these applications. The majority of commercial membranes, prepared in large-scale by a classical solution casting and non-solvent induced phase separation (NIPS), have a broad pore size distribution, limiting their application when strict selectivity is essential. There is only one kind of commercial polymeric isoporous membranes in the market: the track-etched membranes (e. g. Nuclepore, Cyclopore), prepared by the bombardment of fission fragments in a nuclear reactor or ion beams in high energy accelerators, mostly available with pores of a few micrometers or down tenths of micrometer 1,2 . The track-etched membranes are usually made of polycarbonate (PC) or poly(ethylene terephthalate) (PET). Their pore density is low, they are normally commercialized in small discs, the isoporosity is not always perfect due to the possible overlap of tracks during the bombardment preparation step 3 . Beside track-etching, among the most interesting research approaches to develop isoporous membranes in the last decade is the self-assembly and non-solvent induced phase separation (SNIPS) of block copolymers, also a relevant topic in our group 4 . Most membranes under this category have pores in the range of 20-60 nm, with some reports down to a few nanometers. While the SNIPS process can be done in large membrane machines, the obtained morphology is highly dependent on the composition of the block copolymer, the solvent and conditions used for the casting process. The materi...

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Fabrication and characterization of a microporous polymeric micro-filter for isolation ofCryptosporidium parvumoocysts

Cited by 21 publications

References 21 publications

A high-flux isopore micro-fabricated membrane for effective concentration and recovering of waterborne pathogens

A high-flux isopore micro-fabricated membrane for effective concentration and recovering of waterborne pathogens

25th Anniversary Article: Scalable Multiscale Patterned Structures Inspired by Nature: the Role of Hierarchy

Nanofabrication of Isoporous Membranes for Cell Fractionation

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