A high-flux isopore micro-fabricated membrane for effective concentration and recovering of waterborne pathogens

Warkiani, Majid Ebrahimi; Lou, Chao-Ping; Liu, Hao-Bing; Gong, Haiqing

doi:10.1007/s10544-012-9647-6

Cited by 33 publications

(34 citation statements)

References 27 publications

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“…Isoporous membranes have uniformity in pore size and that is ideal for many applications including, but not limited to, molecular separation, drug delivery, pathogen detection, tissue engineering, and microfluidics. [60] The most obvious advantages of isoporous membranes over traditional membranes are that they have a sharp molecular weight cut-off for . Angewandte Reviews A. G. Fane et al…”

Section: Isoporous Membranesmentioning

confidence: 99%

“…The traditional isoporous fabrication technique of track-etching is applied successfully to polymeric membranes, although the limited porosity can increase fouling issues; ideal membranes would be isoporous and highly porous. The techniques of microelectromechanical systems (MEMS) adapted from the semiconductor industry including electroplating [60] and lithography [61] are already mature enough to fabricate isoporous membranes using inorganic materials such as silicon, silicon oxide, and silicon nitride. The methods of embossing, micromolding, and nano-imprinting [62] have extended the possibility to organic and polymeric materials.…”

mentioning

confidence: 99%

“…The majority of MEMS-based membranes are relatively large pore size (MF range), although fine pores are possible. [60] Anodization is another isoporous membrane fabrication technology which exploits the growth of self-assembled porous oxide on metallic thin films (normally aluminum) by an appropriate voltage in an electrolyte solution. Apart from the limited choice of suitable metallic materials, producing large areas of defect-free isoporous membrane is still a challenge due to the fragility of metal oxides.…”

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confidence: 99%

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Synthetic Membranes for Water Purification: Status and Future

2015

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Membrane technology offers the best options to "drought proof" mankind on an increasingly thirsty planet by purifying seawater or used (waste) water. Although desalination by reverse osmosis (RO) and wastewater treatment by membrane bioreactors are well established the various membrane technologies still need to be significantly improved in terms of separation properties, energy demand and costs. We can now define the ideal characteristics of membranes and advances in material science and novel chemistries are leading to increasingly effective membranes. However developments in membranes must be matched by improved device design and membrane engineering. It is likely that limitations in fluid mechanics and mass transfer will define the upper bounds of membrane performance. Nevertheless major advances and growth over the next 20 years can be anticipated with RO remaining as the key to desalination and reclamation, with other membrane processes growing in support and in niche areas.

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Section: Isoporous Membranesmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Synthetic Membranes for Water Purification: Status and Future

2015

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“…Microfluidic channels were fabricated using soft lithography process described elsewhere. 31 To obtain microfluidic channels of 40-lm height, SU8-50 was spin coated (MicroChem Corp.) on a silicon wafer at 3000 rpm for 30 s, then it was soft baked on a hot-plate at 658C for 5 min and 958C for 30 min until the solvent evaporated and the film was densified. After cooling down, SU8 resist was subjected to 360-440 nm UV radiation at 300 mJ cm 22 through a mask with predefined patterns.…”

Section: Fabrication Of Microfluidic Channelsmentioning

confidence: 99%

A hybrid microfluidic system for regulation of neural differentiation in induced pluripotent stem cells

Hesari

Soleimani

Atyabi

et al. 2016

J Biomedical Materials Res

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Controlling cellular orientation, proliferation, and differentiation is valuable in designing organ replacements and directing tissue regeneration. In the present study, we developed a hybrid microfluidic system to produce a dynamic microenvironment by placing aligned PDMS microgrooves on surface of biodegradable polymers as physical guidance cues for controlling the neural differentiation of human induced pluripotent stem cells (hiPSCs). The neuronal differentiation capacity of cultured hiPSCs in the microfluidic system and other control groups was investigated using quantitative real time PCR (qPCR) and immunocytochemistry. The functionally of differentiated hiPSCs inside hybrid system's scaffolds was also evaluated on the rat hemisected spinal cord in acute phase. Implanted cell's fate was examined using tissue freeze section and the functional recovery was evaluated according to the Basso, Beattie, and Bresnahan (BBB) locomotor rating scale. Our results confirmed the differentiation of hiPSCs to neuronal cells on the microfluidic device where the expression of neuronal-specific genes was significantly higher compared to those cultured on the other systems such as plain tissue culture dishes and scaffolds without fluidic channels. Although survival and integration of implanted hiPSCs did not lead to a significant functional recovery, we believe that combination of fluidic channels with nanofiber scaffolds provides a great microenvironment for neural tissue engineering, and can be used as a powerful tool for in situ monitoring of differentiation potential of various kinds of stem cells. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1534-1543, 2016.

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“…Their platform utilized a modified weir-type structure along with fluidic channels (Figure 1b) to continuously separate and capture CTCs at flow rates of up to 20 mL/h. Micropillar arrays with different gap sizes have also been employed to demonstrate the effective isolation of CTCs from blood (26), the enrichment of fetal nucleated red blood cells (27), leukapheresis (28), and the removal of pathogens (29), but their reported throughputs were lower.…”

Section: Microfluidic Microfiltrationmentioning

confidence: 99%

Large-Volume Microfluidic Cell Sorting for Biomedical Applications

Warkiani

Wu²,

Tay

et al. 2015

Annu. Rev. Biomed. Eng.

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102

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Microfluidic cell-separation technologies have been studied for almost two decades, but the limited throughput has restricted their impact and range of application. Recent advances in microfluidics enable high-throughput cell sorting and separation, and this has led to various novel diagnostic and therapeutic applications that previously had been impossible to implement using microfluidics technologies. In this review, we focus on recent progress made in engineering large-volume microfluidic cell-sorting methods and the new applications enabled by them.

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A high-flux isopore micro-fabricated membrane for effective concentration and recovering of waterborne pathogens

Cited by 33 publications

References 27 publications

Synthetic Membranes for Water Purification: Status and Future

Synthetic Membranes for Water Purification: Status and Future

A hybrid microfluidic system for regulation of neural differentiation in induced pluripotent stem cells

Large-Volume Microfluidic Cell Sorting for Biomedical Applications

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