Fabrication and characterization of 3D scaffolds made from blends of sodium alginate and poly(vinyl alcohol)

Seok, Ji Min; Oh, Se Heang; Lee, Sang Jin; Lee, Jun Hee; Kim, Wan Doo; Park, Sang Hyug; Nam, Seung Yun; Shin, Heungsoo; Park, Su A

doi:10.1016/j.mtcomm.2018.09.013

Cited by 27 publications

(11 citation statements)

References 20 publications

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“…Na-Alg/cisplatin UV, SEM, TEM, Zeta Potential, DLS, ICP-MS Use for chemo/radiotherapy of proliferating macrophages [44] Na-Alg/Graphene oxide/poly(N-isopropyl acrylamide) TEM, FTIR, XRD, DSC, SEM used as a drug carrier for controlled delivery of bioactive agents to a specific target. [45] Na-Alg/PVA FTIR, TGA implantable drug-releasing scaffolds in tissue engineering, and as wound dressings in biomedical engineering applications [46] Na-Alg/Psyllium-fenugreek PCR, EE, OM Use for enhancement of probiotic bacterial growth in the gastrointestinal environment.…”

Section: Blends and Composite Of Na-algmentioning

confidence: 99%

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A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications

et al. 2021

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Sodium alginate (Na-Alg) is water-soluble, neutral, and linear polysaccharide. It is the derivative of alginic acid which comprises 1,4-β-d-mannuronic (M) and α-l-guluronic (G) acids and has the chemical formula (NaC6H7O6). It shows water-soluble, non-toxic, biocompatible, biodegradable, and non-immunogenic properties. It had been used for various biomedical applications, among which the most promising are drug delivery, gene delivery, wound dressing, and wound healing. For different biomedical applications, it is used in different forms with the help of new techniques. That is the reason it had been blended with different polymers. In this review article, we present a comprehensive overview of the combinations of sodium alginate with natural and synthetic polymers and their biomedical applications involving delivery systems. All the scientific/technical issues have been addressed, and we have highlighted the recent advancements.

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Section: Blends and Composite Of Na-algmentioning

confidence: 99%

“…Additionally, three-dimensional printing bio-inks are used for numerous biomaterials. Seok et al [46] synthesized the PVA base Na-Alg blends and used them for the fabrication of a 3D scaffold. These blends were prepared by using the post crosslinking method.…”

Section: Pva-based Na-algmentioning

confidence: 99%

A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications

et al. 2021

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“…Glutaraldehyde, used as a cytotoxicity agent, can be crosslinked with PVA to obtain proper mechanical and physical properties [ 120 ]. However, because PVA exhibits poor cell affinity, its physical modification is achieved by alternative methods, such as freeze-thawing [ 120 ] and homogeneously blending with other hydrogels to obtain stable and intended composites [ 122 , 123 ].…”

Section: Bio-inks: Biomaterials For 3d Bioprintingmentioning

confidence: 99%

Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering

Park

Kim

et al. 2020

Polymers

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Three-dimensional (3D) bioprinting technology has emerged as a powerful biofabrication platform for tissue engineering because of its ability to engineer living cells and biomaterial-based 3D objects. Over the last few decades, droplet-based, extrusion-based, and laser-assisted bioprinters have been developed to fulfill certain requirements in terms of resolution, cell viability, cell density, etc. Simultaneously, various bio-inks based on natural–synthetic biomaterials have been developed and applied for successful tissue regeneration. To engineer more realistic artificial tissues/organs, mixtures of bio-inks with various recipes have also been developed. Taken together, this review describes the fundamental characteristics of the existing bioprinters and bio-inks that have been currently developed, followed by their advantages and disadvantages. Finally, various tissue engineering applications using 3D bioprinting are briefly introduced.

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“…In addition, to improve mechanical stability, multi-nozzle systems have been used to simultaneously print a support structure made of PCL alongside alginate hydrogel structures [250,251]. Other ways to improve the mechanical stability after print are by formulation of alginate ink mixed with PVA powder (printability decreased and compressive modulus decreased from 56 to 13 kPa with increasing PVA content from 0 to 30% v/v [252]), or TiO 2 (Young's modulus of 13 MPa compared with control of 9 MPa), or β-TCP (Young's modulus of 8 MPa) [253]. For light-assisted fabrication, methacrylated alginate hydrogels have been photopolymerized with UV light allowing tunable swelling and mechanical properties [254].…”

Section: Structural and Mechanical Propertiesmentioning

confidence: 99%

“…Inclusion of NiCu [237], e-polylysine [238], carrageenan [239], gelatin [240][241][242], cellulose [243,244], PVA [252], TiO 2 [253], β-TCP [253]; Feature size 150 µm, E: 280 kPa [240] Myoblasts [242]; endothelial cells [259]; E.coli [260], growth factor [250], human adipose stem cells [248]; human induced pluripotent stem cells [261]; chondrocytes [243,244,251]; Schwann cells [265] Cellulose (4.3.4) Mixed with alginate [244,[266][267][268][269][270][271][272]; As reinforcement material, E: 2.5-22.5 kPa [281] Feature size 500 µm [280]; Tensile E: 0.67-0.63 GPa [282] Chondrocytes for cartilage tissue engineering [244,269,271]; human induced pluripotent stem cells, bone-marrow hMSCs [272]; pancreatic cancer cells [268]; fibroblast and hepatoma cells [270]; NIH 3T3 cells [274] Collagen (4.4.1)…”

Section: ) Applicationsmentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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Fabrication and characterization of 3D scaffolds made from blends of sodium alginate and poly(vinyl alcohol)

Cited by 27 publications

References 20 publications

A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications

A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications

Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

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