Fabrication and aggregation of thermoresponsive glucose-functionalized double hydrophilic copolymers

Lou, Song; Zhang, Hua; Williams, Gareth R.; Branford-White, Christopher; Nie, Huali; Quan, Jing; Zhu, Li‐Min

doi:10.1016/j.colsurfb.2012.12.012

Cited by 17 publications

(16 citation statements)

References 43 publications

(42 reference statements)

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“…OVAG were synthesized via the chemoenzymatic synthesis of carbohydrates as described in the literature. 36,37 RAFT polymerization of OVAG and NIPAm (Experiment 1 in Table 1). In a typical experiment, NIPAm (0.79 g, 7.00 Â 10 À3 mol) was rst weighed in a 25 mL one-neck round-bottom ask, and 25 mol% of OVAG (0.58 g, 1.75 Â 10 À3 mol) based on the amount of NIPAm used was introduced into the same ask.…”

Section: Synthesesmentioning

confidence: 99%

“…The LCST was dened as the temperature corresponding to a 50% of the maximum absorbance. 37 Laser Light Scattering (LLS) measurement of block glycopolymer. P(NIPAm-co-OVAG)-b-PNIPAm-1 was dissolved in double distilled water to prepare an aqueous solution with glycopolymer concentration of 0.8 mg mL À1 .…”

Section: Analytical Techniquesmentioning

confidence: 99%

“…It has been reported that the LCST value of PNIPAm-based copolymer can be precisely designed to be in the range 32-40 C by adjusting the relative amount of monomers, and LCST value increases with the molar fraction of hydrophilic monomers in the copolymers. 37 Fig. 3 shows the absorbance depends on the temperature of the glycopolymers micellar solution.…”

Section: Lcst Determination Of Glycopolymersmentioning

confidence: 99%

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Lectin recognizing thermoresponsive double hydrophilic glycopolymer micelles by RAFT polymerization

et al. 2014

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Section: Synthesesmentioning

confidence: 99%

Section: Analytical Techniquesmentioning

confidence: 99%

Section: Lcst Determination Of Glycopolymersmentioning

confidence: 99%

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Lectin recognizing thermoresponsive double hydrophilic glycopolymer micelles by RAFT polymerization

et al. 2014

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“…In our previous work, we have synthesized various thermoresponsive glycopolymers and proven that these double-hydrophilic glycopolymers are able to self-assemble into micelles with tunable sizes and morphologies in water at different temperatures. 31–36 In this work, our focus is to design reliable procedure to synthesize glycopolymer-grafted AuNRs (GlycoAuNRs) combining both the biocompatibility and liver-targeting effect. Afterwards, their interactions with lectin-ligands, the ability in cell recognition, and the integration of tumor clinics and treatment are investigated (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Galactose-functionalized GlycoAuNR as a photothermal conversion complex: Its binding to lectin RCA₁₂₀ and hepatoma-targeting therapy

Zheng

Zhang

et al. 2020

J Biomater Appl

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Glycopolymer-grafted gold nanorods (GlycoAuNRs) were designed and fabricated as a heptoma-targeting phototherapy nanoparticles. The block glycopolymer, poly (diethyleneglycol methacrylate)-block-poly(6-O-vinyladipoyl-α-D-galactose) (PDEGMA-b-POVNGA), was synthesized by RAFT polymerization and modified AuNRs with Au-S bonds via reducing the thioester at the end of glycopolymer to thiol (–SH). Galactose pendants of thermosensitive AuNRs@PDEGMA-b-POVNGA were exposed when the temperature of aqueous dispersion is above lower critical solution temperature, which was responsible for specific binding ability with ricinus communis agglutinin. In vitro experiment indicated that the synthesized glycopolymer could significantly improve cytocompatibility of AuNRs and target to hepatocellular carcinoma cells, owing to the galactose moiety that recognized the overexpressed asialoglycoprotein receptor on the hepatocellular carcinoma cells. Interestingly, the addition of ricinus communis agglutinin could inhibit the growth of the hepatocellular carcinoma cells in some extent. Furthermore, the photothermal therapy assay proved that glycoAuNRs-ricinus communis agglutinin could realize highly effective photothermal treatment for the tumor cells in vitro upon laser irradiation by cooperative effect.

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“…Sendo assim, os copolímeros à base de NIPAM e ADG têm sido empregados em estudos de reconhecimento de proteínas e liberação controlada de fármacos (JAFARI; YILMAZ; BECER, 2021; LOU; WANG; WILLIAMS; NIE et al, 2014; LOU; ZHANG; WILLIAMS;BRANFORD- WHITE et al, 2013;RAKU;TOKIWA, 2001;BLIGH; QUAN et al, 2014; QUAN et al, 2014). Entretanto, os efeitos da adição crescente de ADG nas propriedades dos copolímeros poli(NIPAM/ADG) ainda não foram reportados.…”

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Modelagem Molecular Por Homologia Da Enzima Diidroorotato Desidrogenase Da Leishmania Major E Aplicação De Técnicas De Docagem E Dinâmica Molecular

Rocha¹,

Rocha²,

Júnior³

et al. 2021

Química: Debate Entre a Vida Moderna E O Meio Ambiente 2

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Fabrication and aggregation of thermoresponsive glucose-functionalized double hydrophilic copolymers

Cited by 17 publications

References 43 publications

Lectin recognizing thermoresponsive double hydrophilic glycopolymer micelles by RAFT polymerization

Lectin recognizing thermoresponsive double hydrophilic glycopolymer micelles by RAFT polymerization

Galactose-functionalized GlycoAuNR as a photothermal conversion complex: Its binding to lectin RCA₁₂₀ and hepatoma-targeting therapy

Modelagem Molecular Por Homologia Da Enzima Diidroorotato Desidrogenase Da Leishmania Major E Aplicação De Técnicas De Docagem E Dinâmica Molecular

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Fabrication and aggregation of thermoresponsive glucose-functionalized double hydrophilic copolymers

Cited by 17 publications

References 43 publications

Lectin recognizing thermoresponsive double hydrophilic glycopolymer micelles by RAFT polymerization

Lectin recognizing thermoresponsive double hydrophilic glycopolymer micelles by RAFT polymerization

Galactose-functionalized GlycoAuNR as a photothermal conversion complex: Its binding to lectin RCA120 and hepatoma-targeting therapy

Modelagem Molecular Por Homologia Da Enzima Diidroorotato Desidrogenase Da Leishmania Major E Aplicação De Técnicas De Docagem E Dinâmica Molecular

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Galactose-functionalized GlycoAuNR as a photothermal conversion complex: Its binding to lectin RCA₁₂₀ and hepatoma-targeting therapy