We investigate global symmetries for 6D SCFTs and LSTs having a single "unpaired" tensor, that is, a tensor with no associated gauge symmetry. We verify that for every such theory built from F-theory whose tensor has Dirac self-pairing equal to −1, the global symmetry algebra is a subalgebra of e 8 . This result is new if the F-theory presentation of the theory involves a one-parameter family of nodal or cuspidal rational curves (i.e., Kodaira types I 1 or II) rather than elliptic curves (Kodaira type I 0 ). For such theories, this condition on the global symmetry algebra appears to fully capture the constraints on coupling these theories to others in the context of multi-tensor theories. We also study the analogous problem for theories whose tensor has Dirac self-pairing equal to −2 and find that the global symmetry algebra is a subalgebra of su(2). However, in this case there are additional constraints on F-theory constructions for coupling these theories to others.