F-18 FDG PET/CT for Detecting Bone and Bone Marrow Involvement in Sarcoidosis Patients

Mostard, Rémy L M; Prompers, L.; Weijers, R.; Kroonenburgh, Marinus J. van; Wijnen, Petal A.; Geusens, Piet; Drent, Marjolein

doi:10.1097/rlu.0b013e3182335f9b

Cited by 80 publications

(49 citation statements)

References 15 publications

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“…Such an increased diagnostic yield closely corresponds to the results of Teirstein et al, who found occult sites on 18 F-FDG PET in 15% of patients that went undetected clinically or by conventional radiography and MDCT (22). An even higher prevalence (34%) of bone and bone marrow involvement undetected on CT has been reported (26). The additional information provided by 18 F-FDG PET/CT is likely to influence clinical management.…”

Section: Discussionsupporting

confidence: 67%

The Utility of ¹⁸F-FDG PET/CT for Diagnosis and Adjustment of Therapy in Patients with Active Chronic Sarcoidosis

et al. 2012

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Section: Discussionsupporting

confidence: 67%

The Utility of ¹⁸F-FDG PET/CT for Diagnosis and Adjustment of Therapy in Patients with Active Chronic Sarcoidosis

et al. 2012

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“…Positron emission tomography/computed tomography (PET/CT) imaging can be useful in the assessment of bone involvement in sarcoidosis patients. ( 31 ) …”

Section: Osseous Sarcoidosismentioning

confidence: 99%

Musculoskeletal involvement in sarcoidosis

Akasbi¹,

Zahra²,

Harzy³

2014

J. bras. pneumol.

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Sarcoidosis is a multisystem inflammatory disorder of unknown cause. It most commonly affects the pulmonary system but can also affect the musculoskeletal system, albeit less frequently. In patients with sarcoidosis, rheumatic involvement is polymorphic. It can be the presenting symptom of the disease or can appear during its progression. Articular involvement is dominated by nonspecific arthralgia, polyarthritis, and Löfgren's syndrome, which is defined as the presence of lung adenopathy, arthralgia (or arthritis), and erythema nodosum. Skeletal manifestations, especially dactylitis, appear mainly as complications of chronic, multiorgan sarcoidosis. Muscle involvement in sarcoidosis is rare and usually asymptomatic. The diagnosis of rheumatic sarcoidosis is based on X-ray findings and magnetic resonance imaging findings, although the definitive diagnosis is made by anatomopathological study of biopsy samples. Musculoskeletal involvement in sarcoidosis is generally relieved with nonsteroidal anti-inflammatory drugs or corticosteroids. In corticosteroid-resistant or -dependent forms of the disease, immunosuppressive therapy, such as treatment with methotrexate or anti-TNF-α, is employed. The aim of this review was to present an overview of the various types of osteoarticular and muscle involvement in sarcoidosis, focusing on their diagnosis and management.

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“…It is currently unclear how often asymptomatic sarcoid bone lesions are incidentally detected in PET imaging [7]. Mostard et al [10] showed that more than one-third (32/94) of PET-CT-positive sarcoidosis patients had osseous abnormalities on PET-CT; however, there was no single preference of bone localization. Another interesting finding in their study is that corresponding CT lesions were identified in only 2 of the 32 patients with PET-detected bone abnormalities.…”

Section: Discussionmentioning

confidence: 98%

Bone and bone marrow involvement in sarcoidosis

2015

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Bone and bone marrow involvement in sarcoidosis have been infrequently reported. We aimed to describe the clinical features, radiological descriptions, pathological examinations, and outcomes of three patients with osseous sarcoidosis and one patient with bone marrow sarcoidosis seen at our institution. Our case series included fluorodeoxyglucose positron emission tomography descriptions in assessing the whole-body extent of sarcoidosis. In the era of advanced imaging, large bone and axial skeleton sarcoidosis lesions are more common than previously reported.

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F-18 FDG PET/CT for Detecting Bone and Bone Marrow Involvement in Sarcoidosis Patients

Cited by 80 publications

References 15 publications

The Utility of ¹⁸F-FDG PET/CT for Diagnosis and Adjustment of Therapy in Patients with Active Chronic Sarcoidosis

The Utility of ¹⁸F-FDG PET/CT for Diagnosis and Adjustment of Therapy in Patients with Active Chronic Sarcoidosis

Musculoskeletal involvement in sarcoidosis

Bone and bone marrow involvement in sarcoidosis

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F-18 FDG PET/CT for Detecting Bone and Bone Marrow Involvement in Sarcoidosis Patients

Cited by 80 publications

References 15 publications

The Utility of 18F-FDG PET/CT for Diagnosis and Adjustment of Therapy in Patients with Active Chronic Sarcoidosis

The Utility of 18F-FDG PET/CT for Diagnosis and Adjustment of Therapy in Patients with Active Chronic Sarcoidosis

Musculoskeletal involvement in sarcoidosis

Bone and bone marrow involvement in sarcoidosis

Contact Info

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The Utility of ¹⁸F-FDG PET/CT for Diagnosis and Adjustment of Therapy in Patients with Active Chronic Sarcoidosis

The Utility of ¹⁸F-FDG PET/CT for Diagnosis and Adjustment of Therapy in Patients with Active Chronic Sarcoidosis