Rosacea is a common chronic inflammatory facial skin disease which is characterized by transient/persistent centrofacial erythema, telangiectasias, inflammatory papules and pustules, and phymatous changes. Additional to these visible features, patients often suffered self-report symptoms like burning, stinging, dryness and so on. 1 The pathogenesis of rosacea is still unclear. Existing studies have shown that the main factors involved in the pathogenesis of rosacea include the immune system, microbes and the cathelicidin axis, neurovascular processes and neurogenic inflammation, and genetics. 2,3 Furthermore, an accumulating amount of direct and indirect evidence suggests that the destruction of the skin barrier may play an essential role in the pathogenesis of rosacea, which could explain the widely accepted character of the high sensitivity of the facial skin in patients