The association between rosacea and the condition of low tolerance to skincare of the facial skin: a case‐control study in China

Abstract

Rosacea is a common chronic inflammatory facial skin disease which is characterized by transient/persistent centrofacial erythema, telangiectasias, inflammatory papules and pustules, and phymatous changes. Additional to these visible features, patients often suffered self-report symptoms like burning, stinging, dryness and so on. 1 The pathogenesis of rosacea is still unclear. Existing studies have shown that the main factors involved in the pathogenesis of rosacea include the immune system, microbes and the cathelicidin axis, neurovascular processes and neurogenic inflammation, and genetics. 2,3 Furthermore, an accumulating amount of direct and indirect evidence suggests that the destruction of the skin barrier may play an essential role in the pathogenesis of rosacea, which could explain the widely accepted character of the high sensitivity of the facial skin in patients

A Review of the Challenges and Nuances in Treating Rosacea in Asian Skin Types Using Cleansers and Moisturizers as Adjuncts

“…In a retrospective case-control survey in China of 997 patients with rosacea and 1012 controls with healthy skin, the odds ratio (OR) of developing rosacea was increased in those with a history of allergic reaction to skincare products: OR = 5.110, 95% CI = 3.893-6.706, P<.001, and in those with a history of allergic reaction to skincare in beauty salons: OR = 3.002, 95% CI = 1.506-5.981, P=.002. 19 A cross-sectional study of university students in China, including 310 patients with rosacea and 3,129 healthy controls, found that both frequent use of facial cleansers (P=.03) and extended baths (P=.02) were significantly associated with rosacea. 20 A retrospective, multi-center case-control survey study in China of 1,245 patients with rosacea and 1,538 controls with healthy skin found an association between rosacea and certain behaviors including: using a foaming cleanser (OR = 1.45, P=.01), wearing makeup more than 6 times a week (OR = 2.839, P<.001), applying a facial mask more than 4 times a week (OR = 2.56-3.069, P<.001), visiting the beauty salon than once a week (OR = 4.946, P=.0018), and using products from a beauty salon (OR = 2.334, P=.0018).…”