Eye Preservation Brachytherapy for Orbital and Adjacent Tumors: Preliminary Results

Perioperative Intensity-Modulated Brachytherapy for Refractory Orbital Rhabdomyosarcomas in Children

“…They reported that two patients with RMS, which recurred 4 and 7 months after BT, were treated with another cycle of BT and EBRT, but exenteration unfortunately was necessary [47]. Our group employed a manual BT technique, as described above, using flexible catheters without mold to allow maximum adaptation to the anatomic region and using iridium-192 as stepping source in afterloading technique to allow IMBT [28,44]. A more detailed overview of different BT methods for the treatment of malignancies involving the skull base and orbit has recently been published [43].…”

Role of Perioperative Brachytherapy in the Treatment of Malignancies Involving the Skull Base and Orbit

“…The Amsterdam University group and the Kiel University group published their first positive experiences with intraorbital implants at about the same time. 14,21,24,35 Distinctively from other groups treating skull base malignancies by BT in form of perioperative BT in AL technique, Nag et al 11,16,18,20,[28][29][30] developed intraoperative high-dose rate (IOHDR) BT for intraoperative radiation. Both methods have in common that BT is performed after surgical tumor resection.…”

“…On the contrary, we had no worse experience with starting IMBT between day 7 and day 10 after surgery. 5,14 Experience With Intraoperative BT in AL Technique IOHDR BT has been used for the treatment of head and neck cancers by Nag et al 11,16,18,20,[28][29][30] from the Ohio group since the 90s. They published their preliminary experience from a pilot study of IOHDR for advanced head and neck cancer in 1996.…”

“…After wound healing, 15 to 30 Gy total BT dose were administered as fractionated doses (5 Gy/d on up to 5 d/wk) in our patients. Preliminary feasibility data have been already published in part, 14,37 whereas further follow-up analysis data have been not yet published.…”

Feasibility of Combined Operation and Perioperative Intensity-Modulated Brachytherapy of Advanced/Recurrent Malignancies Involving the Skull Base

“…The motivation for developing this therapeutic approach was the desire to elaborate an interdisciplinary method which is effective in gaining local tumor control but one which, at the same time, allows for the preservation of visual acuity also in patients who have undergone previous therapeutic irradiation. Early results from patients with orbital malignancies which have been treated with this method by our interdisciplinary team have been encouraging [17][18][19][20]. The aim of this retrospective analysis was to assess the technical feasibility and toxicity involved in this method and to evaluate the outcomes of patients who have received such treatments -with a particular emphasis on the posttreatment intactness of their visual systems.…”