Feasibility of Combined Operation and Perioperative Intensity-Modulated Brachytherapy of Advanced/Recurrent Malignancies Involving the Skull Base

Abstract

Perioperative fractionated IMBT after extensive but vision-preserving tumor resection seems to be a safe and well-tolerated treatment of advanced/recurrent malignancies involving the skull base. These preliminary data suggest that combined operation and perioperative fractionated IMBT is a palliative therapeutic option in the management of fatal malignancies involving the base of the skull, a strategy which leaves the patients' visual acuity intact.

Fractionated Stereotactic Radiation Therapy in the Management of Benign Cavernous Sinus Meningiomas

“…With 10-15% of all meningiomas, cavernous sinus meningiomas are relatively rare lesions. Nevertheless, meningiomas, pituitary adenomas and schwannomas are the most benign tumors close to the cavernous sinus [15,22,41]. The treatment of cavernous sinus meningiomas is a challenge for neurosurgeons due to adjacent neurovascular structures, like the venous plexus, internal carotid artery and trigeminal/oculomotor nerves.…”

Differential Expression of Egr1 and Activation of Microglia Following Irradiation in the Rat Brain

“…To reduce side effects, new irradiation strategies have been developed including proton radiotherapy [3], boron neutron capture therapy [32], intensity-modulated stereotactic radiosurgery [8], and intensitymodulated brachytherapy [26]. Unfortunately, for some tumors such as primary lymphomas of the central nervous system (CNS) and particularly for brain metastases, whole-brain γ-irradiation might be inevitable to achieve tumor regression or remission [12].…”

Clinicopathologic Features of Aggressive Meningioma Emphasizing the Role of Radiotherapy in Treatment

“…The use of adjuvant radiotherapy in the treatment of aggressive meningiomas is still controversial. Several irradiation techniques were proposed including fractionated stereotactic radiotherapy (FSRT), radiosurgery, and brachytherapy [9,11,18,26,31,35,37].…”