Eye Manifestations of Congenital Toxoplasmosis

Mets, Marilyn B.; Holfels, Ellen; Boyer, Kenneth M.; Swisher, Charles N.; Roizen, Nancy; Stein, Laszlo; Stein, Mark A.; Hopkins, Joyce; Withers, Shawn; Mack, Douglas G.; LUCIANO, ROSE; Patel, Dushyant V.; Remington, Jack S.; Meier, Paul; McLeod, Rima

doi:10.1016/s0002-9394(14)70986-9

Cited by 92 publications

(79 citation statements)

References 32 publications

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“…However, it should be pointed out that the findings in our study were obtained at the first ophthalmological examination of children up to the age of 12 months and only the paper of Mets et al 14 showed results similar to ours.…”

Section: Discussionsupporting

confidence: 72%

“…[8][9][10][11][12][13] Ocular lesions are the most frequent manifestations of congenital toxoplasmosis. 14,15 Prevalence of retinochoroiditis lesions widely vary in literature. 1,10,12,14 These lesions may already be present at birth or they may appear later.…”

Section: Introductionmentioning

confidence: 99%

“…14,15 Prevalence of retinochoroiditis lesions widely vary in literature. 1,10,12,14 These lesions may already be present at birth or they may appear later. 10 It should be mentioned that this ocular involvement is serious because, in many cases, it affects the macular region.…”

Section: Introductionmentioning

confidence: 99%

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Ocular manifestations of congenital toxoplasmosis

Melamed

Eckert

Spadoni

et al. 2009

Eye

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Purpose To evaluate the ocular manifestations of congenital toxoplasmosis at the first ophthalmological examination of children up to the age of 12 months. Methods Cross-sectional study of 44 children with a confirmed diagnosis of congenital toxoplasmosis. In all patients, complete ophthalmological examinations were performed under sedation. The patients underwent biomicroscopy of the anterior segment, skiascopy under cyclopegia, and indirect binocular ophthalmoscopy with maximum mydriasis. Results The mean age of patients was 4.2 months. Of the 44 children evaluated, 31 (70.4%) presented ocular involvement and 29 (65.9%) of them had retinochoroiditis lesions. The retinochoroiditis lesions were bilateral in 22 (75.8%) patients and unilateral in 7 (24.2%). The retinochoroiditis lesions were active in 8 (15.7%) eyes and had healed in 43 (84.3%). Most of the lesions were concentrated in the papillomacular area (76.3%). Other associated ocular alterations were present in 22 children, the most prevalent being cataract, microphthalmia, and strabismus. Conclusion Ocular involvement in congenital toxoplasmosis might be much more frequent and occurs earlier than previously described.

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

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Ocular manifestations of congenital toxoplasmosis

Melamed

Eckert

Spadoni

et al. 2009

Eye

View full text Add to dashboard Cite

show abstract

“…A RC foi a alteração ocular mais comum em nossa amostra, o que está de acordo com a literatura 1,2,[8][9][10][11][12] . Estudos que abrangem pacientes maiores de 1 ano apresentam freqüência maior de lesões retinianas, explicado pelo fato de que essas lesões seriam, provavelmente, de aparecimento tardio 5,7 e também pela maior facilidade de execução do exame de fundo de olho (FO) nessa faixa etária.…”

Section: Discussionunclassified

“…Em nosso estudo, o não desenvolvimento de nistagmo nas crianças com catarata, provavelmente se deveu ao fato do exame ter sido realizado nos primeiros meses de vida onde se dá o período crítico para o desenvolvimento do reflexo de fixação 16 . As demais alterações oculares encontradas são todas descritas 8,[10][11][12] .…”

Section: Discussionunclassified