Eye Malformations in Children with Heavy Alcohol Exposure in Utero

Flanigan, Elizabeth Y.; Aros, Sofía; Bueno, Maria Ferraz; Conley, Mary; Troendle, James; Cassorla, Fernando; Mills, James L.

doi:10.1016/j.jpeds.2008.04.024

Cited by 15 publications

(9 citation statements)

References 29 publications

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“…The three children with FAS had significant ophthalmological findings (Table ), whereas no such signs were noted among the children with pFAS or ARND. This is in agreement with previous observations that children with complete FAS often have various ophthalmological findings, whereas the eyes are affected less frequently in milder forms of FASD (Miller et al, ; Strömland, ; Grönlund et al, ; Ribeiro et al, ; Flanigan et al, ). Seven of the 12 children with another diagnosis than FAS, but who also had an ophthalmological pathology, had parents with alcohol abuse.…”

Section: Discussionsupporting

confidence: 93%

“…Fetal alcohol spectrum disorders are a worldwide problem that has been studied in many countries, such as the United States (Jones et al, ), South Africa (May et al, ), Russia (Miller et al, ), Italy (May et al, ), Croatia (Petković and Barisić, ), Finland (Autti‐Rämö et al, ), and Sweden (Olegård et al, ; Landgren et al, ). In South America, studies on FASD have been performed in Chile (Flanigan et al, ; Kuehn et al, ), whereas only a few, mostly case studies have been done in Brazil (Silva et al, ; Grinfeld et al, ; Mesquita and Segre, ; Momino et al, ), a country with a high consumption of alcohol in certain socioeconomic settings, according to recent reports (Mendoza‐Sassi and Béria, ; Costa et al, ; Gama et al, ; Silveira et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Fetal alcohol spectrum disorders among children in a Brazilian orphanage

Strömland

Ventura

Mirzaei

et al. 2014

Birth Defects Research

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Fetal alcohol spectrum disorders among children in a Brazilian orphanage

Strömland

Ventura

Mirzaei

et al. 2014

Birth Defects Research

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“…This study suggests that ophthalmic screening should not be used to determine the presence of fetal alcohol syndrome, but that children who meet the criteria for fetal alcohol syndrome should have systematic eye examinations. [40]…”

Section: Optic Nervementioning

confidence: 99%

Ocular manifestations of drug and alcohol abuse

Peragallo¹,

Biousse²,

Newman

2013

Current Opinion in Ophthalmology

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Purpose of review To review commonly encountered adverse ocular effects of illicit drug use. Recent findings Drug and alcohol abuse can produce a variety of ocular and neuro-ophthalmic side effects. Novel, so-called “designer,” drugs of abuse can lead to unusual ocular disorders. Legal substances, when used in manners for which they have not been prescribed, can also have devastating ophthalmic consequences. Summary In this review we will systematically evaluate each part of the visual pathways and discuss how individual drugs may affect them.

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“…Independently of the exposition to high levels of alcohol prenatally, the risk of eye malformations seems to be limited to children who develop FAS. 6 Ocular findings occur in up to 90% of FAS patients 7 and all eye structures may be affected with a wide variety of severity. External ocular signs include short horizontal palpebral fissure, epicanthus, hypertelorism, blepharoptosis, telecanthus, strabismus and nystagmus.…”

Section: Introductionmentioning

confidence: 99%

Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis

et al. 2016

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RESUMOIntrodução: A hipoplasia do disco ótico é característica comum na síndrome fetal-alcoólica. Assim, propusemo-nos a avaliar as alterações morfológicas do disco ótico e a espessura da camada de fibras nervosas retinianas peripapilares, nunca antes estudada nestes doentes. Material e Métodos: Realizamos tomografia de coerência óptica de domínio espectral num grupo de 11 doentes (22 olhos) com síndrome fetal-alcoólica e num grupo controlo ajustado à idade. Avaliamos alguns parâmetros morfológicos do disco ótico (área e diâmetro do disco ótico, área do anel neurorretiniano, razão escavação/disco horizontal e vertical) e a espessura da camada de fibras nervosas retiniana peripapilares. Resultados: Os valores médios da área do disco ótico, anel neurorretiniano e diâmetro do disco ótico foram, respetivamente, no grupo de doentes e no grupo controlo: 1,540 ± 0,268 e 1,748 ± 0,326 mm 2 ; 1,205 ± 0,286 e 1,461 ± 0,314 mm 2 ; 1,417 ± 0,124 e 1,501 ± 0,148 mm (p < 0,05). Não encontramos diferenças significativas entre as razões escavação/disco. A espessura média da camada de fibras nervosas foi significativamente menor nos pacientes (90,500 ± 9,344 µm) relativamente aos controlos (111,000 ± 7,855 µm) (p < 0,0001). Verificamos uma diminuição significativa nos quadrantes superior, inferior e nasal (p < 0,005). O quadrante temporal não revelou diferenças significativas. Discussão: As áreas do disco ótico e anel neurorretiniano e o diâmetro do disco ótico foram significativamente menores nos pacientes com síndrome fetal-alcoólica. Embora a espessura média da camada de fibras nervosas peripapilares se tenha revelado diminuída, o quadrante temporal parece estar poupado. Conclusão: Para além de uma área/ diâmetro do disco ótico e área do anel neurorretiniano menores, descobrimos um padrão heterogéneo de perda da camada de fibras nervosas retinianas peripapilares em pacientes com síndrome fetal-alcoólica, sem atingimento do quadrante temporal. A tomografia de coerência óptica poderá ser útil no estabelecimento do diagnóstico da síndrome fetal-alcoólica. Optic disc hypoplasia is a common feature in fetal alcohol syndrome. Thus, we aimed to evaluate the optic disc morphology changes and the peripapillary retinal nerve fiber layer thickness in these patients. Material and Methods:We performed spectral-domain optical coherence tomography in a cohort of 11 patients (22 eyes) with fetal alcohol syndrome and in an age-matched control group. We evaluated optic nerve head parameters (optic disc area and diameter, rim area, cup/disc horizontal and vertical ratios) and peripapillary retinal nerve fiber layer thickness. Results: Mean optic disc area, rim area and optic disc diameter were, respectively, in fetal alcohol syndrome patients and control subjects: 1.540 ± 0.268 and 1.748 ± 0.326 mm 2 ; 1.205 ± 0.286 and 1.461 ± 0.314 mm 2 ; 1.417 ± 0.124 and 1.501 ± 0.148 mm (p < 0.05). We found no significant differences between groups for cup/disc ratios. Mean retinal nerve fiber layer thickness was significantly lower in fetal alcohol syndro...

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Eye Malformations in Children with Heavy Alcohol Exposure in Utero

Cited by 15 publications

References 29 publications

Fetal alcohol spectrum disorders among children in a Brazilian orphanage

Fetal alcohol spectrum disorders among children in a Brazilian orphanage

Ocular manifestations of drug and alcohol abuse

Pattern of Retinal Nerve Fiber Layer Thickness Loss in Fetal Alcohol Syndrome: A Spectral-Domain Optical Coherence Tomography Analysis

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