Fetal alcohol spectrum disorders among children in a Brazilian orphanage

Strömland, Kerstin; Ventura, Liana; Mirzaei, Layla; Oliveira, Keyla Fontes de; Bandim, José Marcelino; Ivo, Adriana Parente; Brandt, Carlos Teixeira

doi:10.1002/bdra.23326

Cited by 22 publications

(19 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…About 16% of these children presented ocular changes, such as low vision, strabism and morphological changes of optic nerves, which shows the devastating effects of drug abuse during pregnancy. (Strömland et al , 2014)…”

Section: Brazilian Cases Of Teratogenesismentioning

confidence: 99%

Teratogens: a public health issue – a Brazilian overview

et al. 2017

View full text Add to dashboard Cite

Congenital anomalies are already the second cause of infant mortality in Brazil, as in many other middle-income countries in Latin America. Birth defects are a result of both genetic and environmental factors, but a multifactorial etiology has been more frequently observed. Here, we address the environmental causes of birth defects – or teratogens – as a public health issue and present their mechanisms of action, categories and their respective maternal-fetal deleterious effects. We also present a survey from 2008 to 2013 of Brazilian cases involving congenital anomalies (annual average of 20,205), fetal deaths (annual average of 1,530), infant hospitalizations (annual average of 82,452), number of deaths of hospitalized infants (annual average of 2,175), and the average cost of hospitalizations (annual cost of $7,758). Moreover, we report on Brazilian cases of teratogenesis due to the recent Zika virus infection, and to the use of misoprostol, thalidomide, alcohol and illicit drugs. Special attention has been given to the Zika virus infection, now proven to be responsible for the microcephaly outbreak in Brazil, with 8,039 cases under investigation (from October 2015 to June 2016). From those cases, 1,616 were confirmed and 324 deaths occurred due to microcephaly complications or alterations on the central nervous system. Congenital anomalies impact life quality and raise costs in specialized care, justifying the classification of teratogens as a public health issue.

show abstract

Section: Brazilian Cases Of Teratogenesismentioning

confidence: 99%

Teratogens: a public health issue – a Brazilian overview

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Of the studies that used an ACA approach (ie, those studies that used ACA solely, as well as those that used a mixed-methods approach), 10 studies [40][41][42][49][50][51]62,64,[69][70][71] did not report the system used for diagnosing FAS and/or FASD. Of those studies that did report the diagnostic system used, 7 studies 44,54-56,59,60,66 used the 4-Digit Diagnostic Code, 24 2 studies 48,58 used the IOM diagnostic criteria, 23 2 studies 47,68 used the CDC FAS Guidelines, 15 1 study 46 used the FASD Study Group criteria, 17 and 1 study 63 used the Smith' s Recognizable Patterns of Human Malformations.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Prevalence of Fetal Alcohol Spectrum Disorders in Child Care Settings: A Meta-analysis

et al. 2013

View full text Add to dashboard Cite

BACKGROUND: Children often enter a child-care system (eg, orphanage, foster care, child welfare system) because of unfavorable circumstances (eg, maternal alcohol and/or drug problems, child abuse/neglect). Such circumstances increase the odds of prenatal alcohol exposure, and thus this population can be regarded as high risk for fetal alcohol spectrum disorders (FASD). The primary objective was to estimate a pooled prevalence for fetal alcohol syndrome (FAS) and FASD in various child-care systems based on data from existing studies that used an active case ascertainment method. METHODS:A systematic literature review, using multiple electronic bibliographic databases, and meta-analysis of internationally published and unpublished studies that reported the prevalence of FAS and/or FASD in all types of child-care systems were conducted. The pooled prevalence estimates and 95% confidence intervals (CIs) were calculated by using the Mantel-Haenszel method, assuming a random effects model. Sensitivity analyses were performed for studies that used either passive surveillance or mixed methods. RESULTS:On the basis of studies that used active case ascertainment, the overall pooled prevalence of FAS and FASD among children and youth in the care of a child-care system was calculated to be 6.0% (60 per 1000; 95% CI: 38 to 85 per 1000) and 16.9% (169 per 1000; 95% CI: 109 to 238 per 1000), respectively. CONCLUSIONS:The results confirm that children and youth housed in or under the guardianship of the wide range of child-care systems constitute a population that is high-risk for FASD. It is imperative that screening be implemented in these at-risk populations.

show abstract

“…There are no nationwide data on the number of people affected by FAS and FASD. Strömland and colleagues () studied 94 children in orphanage in northeastern Brazil and found that 50% of the biological mothers had known alcohol abuse, and 17% of the children were diagnosed with FASD. Momino and colleagues () investigated a group of 262 convicted male adolescents and 154 male students in the same age range in public schools in southern Brazil.…”

Section: Discussionmentioning

confidence: 99%

“…In Brazil, there are few publications addressing the extent of the problem of FAS/FASD; these studies are confined to limited geographic areas (Momino et al, ; Strömland et al, ). However, a number of studies have shown that alcohol intake during pregnancy in Brazil can be as high as 57% (Kroeff et al, ).…”

mentioning

confidence: 99%

Fetal Alcohol Spectrum Disorders: Health Needs Assessment in Brazil

Rocha

Souza

Wachholz

et al. 2020

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Background Fetal alcohol syndrome (FAS) is a disorder caused by alterations in embryo‐fetal development due to prenatal alcohol exposure. It is estimated that between 0.5 and 2 per 1,000 individuals are born with FAS every year. In Brazil, there are few studies addressing the extent of the problem of FAS/fetal alcohol spectrum disorders (FASD); these studies are confined to limited geographic areas. Therefore, we decided to perform a health needs assessment for FAS/FASD in Brazil. Methods To estimate the prevalence of FAS and FASD in Brazil, we used information from the literature, which estimates between 0.5 and 2/1,000 births per year for FAS and 10 to 50/1,000 for FASD. Results We estimated that approximately 1,500 to 6,000 children are born with FAS every year. Considering the whole population, the prevalence would be 95,377 to 380,000 affected people. However, when we consider FASD as a whole, we estimate that between 1,900,000 and 9,500,000 Brazilians might suffer the more severe consequences of alcohol exposure during pregnancy and be living with FASD. Conclusion The results of the current study indicate that FAS and FASD are prevalent disorders in Brazil, and more policies targeting alcohol intake during pregnancy must be developed.

show abstract

Fetal alcohol spectrum disorders among children in a Brazilian orphanage

Cited by 22 publications

References 38 publications

Teratogens: a public health issue – a Brazilian overview

Teratogens: a public health issue – a Brazilian overview

Prevalence of Fetal Alcohol Spectrum Disorders in Child Care Settings: A Meta-analysis

Fetal Alcohol Spectrum Disorders: Health Needs Assessment in Brazil

Contact Info

Product

Resources

About