Eye Drop Dispenser Type and Medication Possession Ratio in Patients With Glaucoma: Single-Use Containers Versus Multiple-Use Bottles

Adherence to Topical Medication in Patients with Inflammatory Eye Disease

“…Improper drop instillation has been cited as an important feature in non-adherence to glaucoma medications. [11][12][13][14][15][16][17] Although we did not directly observe patients instilling their medication, as only 42% stated they had received instruction on how to do so and 26% of patients reported an insufficient time interval (< five minutes) between consecutive medications, then it is reasonable to assume some patients would be doing this incorrectly.…”

“…They can be grouped into four major types: medication regimen, patient factors, provider factors, and situational or environmental factors. 9 These include poor education, lack of motivation, forgetfulness, drop application, and other practical issues including delivery systems (single-use containers, multiple-use bottles), 15 together with specific individual and age differences. 33 Forgetfulness was the major reason stated for non-adherence in our study and this is well recognized in adherence studies in glaucoma.…”

“…Interventions to improve adherence in glaucoma include patient education, reminder devices and eye drop instillation training. 15,[20][21][22][23][24] Boland et al showed improved adherence to glaucoma medication with telephone or text medication reminders 36 and email reminders also improved adherence but only in younger patients. 37 These measures may not be practical if patients are using medication frequently throughout the day and on regimens that may require a complicated treatment taper or have poor eyesight or hearing.…”

“…1 Previous studies have demonstrated that patient adherence to topical medication in conditions, such as glaucoma can be poor and appears influenced by a number of factors, such as understanding of disease, [2][3][4] rationale of treatment, 2,5,6 having a simplified treatment regimen, [7][8][9][10] ease of drop instillation and whether they are dispensed in single use containers or multiple-use bottles. [11][12][13][14][15][16][17] In the ophthalmic literature there is very little information on adherence in inflammatory eye disease. 18 We wished to evaluate adherence to topical medication in patients with inflammatory eye disease in a tertiary Eye Centre setting and to identify factors that may influence this.…”

Reduction of Eyedrop Volume for Topical Ophthalmic Medications with the Nanodropper Bottle Adaptor

“…[32][33][34] A 2018 study compared the price and medication waste of single-use blister packs with bottles of medication and determined that bottles were, overall, more cost-effective than single-use medications even after accounting for over-or under-consumption of medication on a monthly basis. 35 As the most costeffective means of obtaining topical medications is a stock bottle, the adaptor could, therefore, extend the use of these medications beyond what is currently available through other products. Moreover, one study determined through costadjusted quality of life algorithms that a measure costing $550/year or less to improve medication adherence for glaucoma patients would be considered highly cost effective.…”