Adherence to Topical Medication in Patients with Inflammatory Eye Disease

Javidi, Hedayat; Poonit, Nat; Patel, Radhika Pooja; Barry, Robert J.; Rauz, Saaeha; Murray, Philip I.

doi:10.1080/09273948.2019.1699122

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…Patient compliance with treatment and follow-up appointments is associated with better results. 43,44 Identifying factors that limit compliance are essential to optimize treatment and develop strategies that will enhance compliance with treatment and regular monitoring. 45 The patient's immune profile is a substantial parameter for the management of uveitis.…”

Section: Discussionmentioning

confidence: 99%

The Large Hellenic Study of Uveitis: Diagnostic and Therapeutic Algorithms, Complications, and Final Outcome

Kalogeropoulos

Asproudis

Stefaniotou

et al. 2023

Asia-Pacific Journal of Ophthalmology

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Purpose: The purpose of this study is to present the diagnostic and therapeutic algorithms, complications, and final outcome in the management of uveitic patients at a tertiary academic referral center. Design: Observational study. Methods: Analysis of the archives of 6191 uveitic patients at the Ocular Inflammation Service of the Department of Ophthalmology of the University Hospital of Ioannina in Greece from 1991 to 2020. Results: During the 30 years of the study, the diagnostic ability climbed from 45.43% (1991–1995) to 73.4% (2016–2020). This improvement was linked to several factors including the increase in the number of diagnostic paracenteses for the analysis of intraocular fluids, the range and quality of laboratory blood tests, the multimodal ophthalmic imaging, the proper use of nonophthalmic imaging, and the multidisciplinary approach. The degree of uveitis-related complications was related to the severity and cause of inflammation, the recurrence rate, inappropriate treatment, and the prolonged or initially inactive inflammation. The 3 most common complications included cataract, macular edema, and glaucoma. Apart from the modern treatments and surgical techniques, the 3-month preoperative control of inflammation played a critical role in the surgical outcomes. The percentage of patients with a successful outcome increased from 72% (2001–2005) to 90.50% (2016–2020). The center’s experience, prompt referral, patient’s compliance, and regular follow-ups are associated with a better outcome. The analysis of the results allowed the development of diagnostic and therapeutic algorithms. Conclusions: Developing diagnostic and therapeutic algorithms allows for the efficient management of uveitis, leading to better visual outcome and therefore a better quality of life.

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Section: Discussionmentioning

confidence: 99%

The Large Hellenic Study of Uveitis: Diagnostic and Therapeutic Algorithms, Complications, and Final Outcome

Kalogeropoulos

Asproudis

Stefaniotou

et al. 2023

Asia-Pacific Journal of Ophthalmology

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“…Each patient follows a personalised journey along the dry eye disease care pathway tailored to disease severity, underlying pathophysiology, therapeutic success rates, locally available dry eye disease services, professional opinions, waiting lists and patient choice. Achieving good adherence to treatments in dry eye disease is a well-recognised challenge and also impacts the patient journey along this care pathway [ 26 ]. Figure 1 provides an example NHS dry eye disease care pathway and illustrates the frequency of appointments and multiple treatment trials to optimise patients’ symptoms and signs.…”

Section: The Nhs Dry Eye Disease Care Pathwaymentioning

confidence: 99%

Achieving net-zero in the dry eye disease care pathway

Latham,

Williams,

Grover

et al. 2023

Eye

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Climate change is a threat to human health and wellbeing across the world. In recent years, there has been a surge in awareness of this crisis, leading to many countries and organisations setting “net-zero” targets. This entails minimising carbon emissions and neutralising remaining emissions by removing carbon from the atmosphere. At the 2022 United Nations Climate Change Conference (COP27), commitments to transition away from fossil fuels and augment climate targets were underwhelming. It is therefore imperative for public and private sector organisations to demonstrate successful implementation of net-zero and set a precedent for the global political consensus. As a top 10 world employer, the United Kingdom National Health Service (NHS) has pledged to reach net-zero by 2045. The NHS has already taken positive steps forward, but its scale and complexity as a health system means stakeholders in each of its services must highlight the specifications for further progress. Dry eye disease is a chronic illness with an estimated global prevalence of 29.5% and an environmentally damaging care pathway. Moreover, environmental damage is a known aggravator of dry eye disease. Worldwide management of this illness generates copious amounts of non-recyclable waste, utilises inefficient supply chains and involves recurrent follow-up appointments and prescriptions. By mapping the dry eye disease care pathway to environmental impact, in this review we will highlight seven key areas in which reduced emissions and pollution could be targeted. Examining these approaches for improved environmental sustainability is critical in driving the transformation needed to preserve our health and wellbeing.

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“…The OSDI score is calculated as the mean of the responses of all of the questions answered by the respondent, which is then multiplied by 25, to give a score in the range 0-100, with higher scores representing more severe symptomatology. Based on the resulting scores, patients can be classified as having normal (OSDI=0-12), mild (13)(14)(15)(16)(17)(18)(19)(20)(21)(22), moderate (23)(24)(25)(26)(27)(28)(29)(30)(31)(32) or severe (33+) symptomatology. As mentioned above, while the OSDI was intended for use in OSD, a patient involvement group indicated that many of the questions were applicable to uveitis because of the similarity of presenting symptoms and how these affect daily activities.…”

Section: Study Design and Proceduresmentioning

confidence: 99%

“…17 Recent studies confirm that neuropathic ocular pain specifically is not only prevalent in those with dry eye disease (DED) but also correlates with DED severity and persistence. [18][19][20][21][22] From a patient perspective, a lack of understanding of their condition may inhibit treatment adherence, 23 perpetuating both physical and mental morbidities. 5 A lack of understanding of IED on the behalf of a patient's social contacts may also have an additional impact.…”

Section: Introductionmentioning

confidence: 99%

Anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item

et al. 2021

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ObjectiveTo evaluate whether topical therapy is linked to scores related to anxiety, depression and quality of life (QoL) in inflammatory eye disease (IED).Methods and analysisPatients with ocular surface disease (OSD, N=100) and Uveitis (N=100) completed self-administered validated questions on ocular symptoms and well-being, with supplemental questions on eye drop frequency.ResultsForty (20%) patients had scores consistent with depression and 33 (17%) anxiety. Anxiety, depression, QoL and OSD index (OSDI) scores did not differ significantly between OSD and Uveitis groups. In those with anxiety or depression, QoL was significantly reduced in all WHO Quality Of Life-BREF domains (all p<0.001). Multivariable analysis considering demographic and disease-related factors found daily topical drop frequency to be independently associated with anxiety (p=0.009) but not depression (p=0.300).ConclusionA high proportion of patients with IED demonstrated scores indicative of anxiety and depression. Preliminary evidence suggests that the frequency of topical eye drops potentially plays a significant role in the psychological health status of patients with IED .

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Adherence to Topical Medication in Patients with Inflammatory Eye Disease

Cited by 8 publications

References 34 publications

The Large Hellenic Study of Uveitis: Diagnostic and Therapeutic Algorithms, Complications, and Final Outcome

The Large Hellenic Study of Uveitis: Diagnostic and Therapeutic Algorithms, Complications, and Final Outcome

Achieving net-zero in the dry eye disease care pathway

Anxiety and depression in inflammatory eye disease: exploring the potential impact of topical treatment frequency as a putative psychometric item

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