Eye closure in darkness animates sensory systems

Marx, Esther; Stephan, Thomas; Nolte, A.; Deutschländer, Angela; Seelos, Klaus; Dieterich, Marianne; Brandt, Thomas

doi:10.1016/s1053-8119(03)00150-2

Cited by 167 publications

(144 citation statements)

References 43 publications

(45 reference statements)

Supporting

Mentioning

120

Contrasting

Order By: Relevance

“…These activations can be expected since open eyes produce a stimulation of the visual system which is not the case if the eyes are closed. Furthermore the result is in line with other fMRI studies contrasting eyes-open and eyes-closed states (Marx et al, 2004;Marx et al, 2003). The eyes-closed condition did not elicit any regions of greater activation.…”

Section: Discussionsupporting

confidence: 92%

“…This is important because the two resting conditions do differ substantially in both EEG (Barry et al, 2007;Berger, 1929 ) and fMRI (Bianciardi et al, 2009;Marx et al, 2004;Marx et al, 2003). Indeed our results were highly condition and partly frequency specific.…”

Section: Discussionmentioning

confidence: 65%

“…A comprehensive study of resting state EEG-BOLD coupling covering the common spectral frequency bands and resting states has not yet been performed. Such a study is important, because the profile formed by different EEG rhythms is characteristic of different brain states and brain functions, and because eyes-open and eyes-closed states differ substantially in levels of arousal and EEG (Barry et al, 2007;Berger, 1929 ;Bianciardi et al, 2009;Marx et al, 2004;Marx et al, 2003) as well as in fMRI (Bianciardi et al, 2009;Marx et al, 2004;Marx et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

EEG–BOLD correlations during (post-)adolescent brain maturation

et al. 2011

View full text Add to dashboard Cite

-The transition from adolescence to adulthood is a critical stage in the human lifespan during which the brain still undergoes substantial structural and functional change. The changing frequency composition of the resting state EEG reflects maturation of brain function. This study investigated (post)adolescent brain maturation captured by two independently but simultaneously recorded neuronal signals: EEG and fMRI. Data were collected in a 20 min eyes-open/eyes-closed resting state paradigm. EEG, fMRI-BOLD signal and EEG-BOLD correlations were compared between groups of adults, age 25 (n = 18), and adolescents, age 15 (n = 18). A typical developmental decrease of low-frequency EEG power was observed even at this late stage of brain maturation. Frequency and condition specific EEG-fMRI correlations proved robust for multiple brain regions. However, no consistent change in the EEG-BOLD correlations was identified that would correspond to the neuronal maturation captured by the EEG. This result indicates that the EEG-BOLD correlation measures a distinct aspect of neurophysiological activity that presumably matures earlier, since it is less sensitive to late maturation than the neuronal activity captured by low-frequency EEG.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

EEG–BOLD correlations during (post-)adolescent brain maturation

et al. 2011

View full text Add to dashboard Cite

show abstract

“…This suggests that the conditions affect brain function more profoundly than one could expect from the simple blocking of visual input. However, the coupling differences are in line with EEG (Barry et al, 2007;Berger, 1929 ) and fMRI literature (Bianciardi et al, 2009;Marx et al, 2004;Marx et al, 2003;Yang et al, 2007) reporting EO/EC condition differences. With the increasing interest in resting state brain function, differences between EO and EC have likewise garnered interest, and they also relate to the debate about an optimal 'baseline' .…”

Section: Eeg-bold Signal Correlationssupporting

confidence: 86%

Brain state regulation during normal development: Intrinsic activity fluctuations in simultaneous EEG–fMRI

et al. 2012

View full text Add to dashboard Cite

Brain maturation in adolescence is mirrored by the EEG as a pronounced decrease in low frequency activity. This EEG power attenuation parallels reductions of structural and metabolic markers of neuronal maturation (i.e., gray matter loss and decrease of absolute cerebral glucose utilization). However, it is largely unknown what causes these electrophysiological changes, and how this functional reorganization relates to other functional measures such as the fMRI BOLD signal. In this study, we used simultaneously recorded EEG and fMRI to localize hemodynamic correlates of fluctuating EEG oscillations and to study the development of this EEG-BOLD coupling. Furthermore, the maturational EEG power attenuation was directly compared to BOLD signal power maturation. Both analyses were novel in their developmental perspective and aimed at providing a functional lead to EEG maturation. Data from 19 children, 18 adolescents and 18 young adults were acquired in 10min eyes-open/eyes-closed resting states. Our results revealed that both EEG and BOLD amplitudes strongly decrease between childhood and adulthood, but their functional coupling remains largely unchanged. The global reduction of absolute amplitude of spontaneous slow BOLD signal fluctuation is a novel marker for brain maturation, and parallels the globally decreasing trajectories of EEG amplitudes, gray matter and glucose metabolism during adolescence. Further, the absence of thalamocortical EEG-BOLD coupling in children together with age-related normalized thalamic BOLD power increase indicated maturational changes in brain state regulation. Abstract -Brain maturation in adolescence is mirrored by the EEG as a pronounced decrease in low frequency activity. This EEG power attenuation parallels reductions of structural and metabolic markers of neuronal maturation (i.e., gray matter loss and decrease of absolute cerebral glucose utilization). However, it is largely unknown what causes these electrophysiological changes, and how this functional reorganization relates to other functional measures such as the fMRI BOLD signal. In this study, we used simultaneously recorded EEG and fMRI to localize hemodynamic correlates of fluctuating EEG oscillations and to study the development of this EEG-BOLD coupling. Furthermore, the maturational EEG power attenuation was directly compared to BOLD signal power maturation. Both analyses were novel in their developmental perspective and aimed at providing a functional lead to EEG maturation. Data from 19 children, 18 adolescents and 18 young adults were acquired in 10 min eyes-open/eyes-closed resting states. Our results revealed that both EEG and BOLD amplitudes strongly decrease between childhood and adulthood, but their functional coupling remains largely unchanged. The global reduction of absolute amplitude of spontaneous slow BOLD signal fluctuation is a novel marker for brain maturation, and parallels the globally decreasing trajectories of EEG amplitudes, gray matter and glucose metabolism during adolescence. Furthe...

show abstract

“…Significant differences in the properties of the brain's resting activity have been reported between these 2 states. [29][30][31][32][33][34] These differences include alterations in multiple EEG bands, 35,36 changes in the amplitude of low-frequency fluctuations in the visual cortex and paracentral lobule (note that this study acquired data from the posterior portion of the brain only, and so changes in other regions may also occur 34 ) and differences in activity levels in the sensory cortices. 31 Interestingly, it should be noted that the changes in brain activity seen between the eyes open and eyes closed conditions do not appear to be simply owing to a difference in the amount of light seen.…”

Section: Visual Noisementioning

confidence: 99%