Eye and hand motor interactions with the Symbol Digit Modalities Test in early multiple sclerosis

Nygaard, Gro Owren; Benavent, Sigrid A. de Rodez; Harbo, Hanne F.; Laeng, Bruno; Sowa, Piotr; Damangir, Soheil; Nilsen, Kristian Bernhard; Etholm, Lars; Tønnesen, Siren; Kerty, Emı́lia; Drolsum, Liv; Landrø, Nils Inge; Celius, Elisabeth Gulowsen

doi:10.1016/j.msard.2015.08.003

Cited by 27 publications

(24 citation statements)

References 30 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Future studies should seek to disentangle the impact of motor function impairments, such as eye movements, dysarthria, and upper limbs in the performance of IPS tasks. Previous research has shown that eye movements (Nygaard et al, 2015) or dysarthria (Arnett, Smith, Barwick, Benedict, & Ahlstrom, 2008) are associated with poor performance on cognitive tests; however, more studies are needed across realms of cognition.…”

Section: Discussionmentioning

confidence: 99%

Role of Demographic and Clinical Factors in Cognitive Functioning of Persons with Relapsing-Remitting and Progressive Multiple Sclerosis

Costa

DeLuca

Sandroff

et al. 2017

J Int Neuropsychol Soc

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Role of Demographic and Clinical Factors in Cognitive Functioning of Persons with Relapsing-Remitting and Progressive Multiple Sclerosis

Costa

DeLuca

Sandroff

et al. 2017

J Int Neuropsychol Soc

View full text Add to dashboard Cite

show abstract

“…We tested cognitive functions using two standard tests; 1) the Montreal cognitive assessment (MoCA), 21 and 2) the symbol-digit modalities test (SDMT). 22 The MoCA was originally developed to screen for mild cognitive impairment in a geriatric outpatient population with an impairment threshold of <26. 21 An alternative threshold of <23 was determined in a larger, more heterogeneous population 23 ; we reported results based on both thresholds.…”

Section: Methodsmentioning

confidence: 99%

The feasibility of assessing cognitive and motor function in multiple sclerosis patients using robotics

Simmatis

Jin²,

Taylor

et al. 2020

Multiple Sclerosis Journal - Experimental, Translational and Cl

View full text Add to dashboard Cite

Background Multiple sclerosis (MS) causes pervasive motor, sensory and cognitive dysfunction. The Expanded Disability Status Scale (EDSS) is the gold standard for assessing MS disability. The EDSS is biased towards mobility and may not accurately measure MS-related disabilities in the upper limb or in cognitive functions (e.g. executive function). Objective Our objectives were to determine the feasibility of using the Kinarm robotic system to quantify neurological deficits related to arm function and cognition in MS patients, and examine relationships between traditional clinical assessments and Kinarm variables. Methods Individuals with MS performed 8 robotic tasks assessing motor, cognitive, and sensory ability. We additionally collected traditional clinical assessments and compared these to the results of the robotic assessment. Results Forty-three people with MS were assessed. Most participants could complete the robotic assessment. Twenty-six (60%) were impaired on at least one cognitive task and twenty-six (60%) were impaired on at least one upper-limb motor task. Cognitive domain task performance correlated most strongly with the EDSS. Conclusions Kinarm robotic assessment of people with MS is feasible, can identify a broad range of upper-limb motor and sensory, as well as cognitive, impairments, and complements current clinical rating scales in the assessment of MS-related disability.

show abstract

“…Correlation between the SDMT and PASAT has previously been reported in several studies (Brochet et al., ; Drake et al., ; Lopez‐Gongora, Querol, & Escartin, ; Nygaard et al., ). The highest correlation coefficient between the cognitive tests and the SF‐36 and the MCS was observed for the SDMT.…”

Section: Discussionmentioning

confidence: 99%

“…The oral administration is recommended when testing MS patients to minimize confounding due to upper extremity weakness or ataxia (Benedict et al, 2002). A recent study did, indeed, report a correlation between the written SDMT and the 9HPT (Nygaard et al, 2015). Some authors have, however, found that speech is slow in MS patients, which could contribute to results when using neuropsychological tests such as both the oral SDMT and the PASAT that require rapid spoken response (Arnett, Smith, Barwick, Benedict, & Ahlstrom, 2008).…”

Section: Discussionmentioning

confidence: 99%

Progressive multiple sclerosis, cognitive function, and quality of life

et al. 2018

View full text Add to dashboard Cite

BackgroundPatients with progressive multiple sclerosis (MS) often have cognitive impairment in addition to physical impairment. The burden of cognitive and physical impairment progresses over time, and may be major determinants of quality of life. The aim of this study was to assess to which degree quality of life correlates with physical and cognitive function in progressive MS.MethodsThis is a retrospective study of 52 patients with primary progressive (N = 18) and secondary progressive MS (N = 34). Physical disability was assessed using the Expanded Disability Status Scale, Timed 25 Foot Walk (T25FW) test and 9‐Hole Peg Test (9HPT). Cognitive function was assessed using Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test, and Trail Making Test B (TRAIL‐B). In addition, quality of life was assessed by the Short Form 36 (SF‐36) questionnaire.ResultsOnly measures of cognitive function correlated with the overall SF‐36 quality of life score and the Mental Component Summary score from the SF‐36. The only physical measure that correlated with a measure of quality of life was T25FW test, which correlated with the Physical Component Summary from the SF‐36. We found no other significant correlations between the measures of cognitive function and the overall physical measures but interestingly, we found a possible relationship between the 9HPT score for the nondominant hand and the SDMT and TRAIL‐B.ConclusionOur findings support inclusion of measures of cognitive function in the assessment of patients with progressive MS as these correlated closer with quality of life than measures of physical impairment.

show abstract

Eye and hand motor interactions with the Symbol Digit Modalities Test in early multiple sclerosis

Abstract: RRMS patients have an increased SI time compared to controls. Cognitive tests results, exemplified by the wSDMT, may be confounded by eye and hand motor function.

Cited by 27 publications

References 30 publications

Role of Demographic and Clinical Factors in Cognitive Functioning of Persons with Relapsing-Remitting and Progressive Multiple Sclerosis

Role of Demographic and Clinical Factors in Cognitive Functioning of Persons with Relapsing-Remitting and Progressive Multiple Sclerosis

The feasibility of assessing cognitive and motor function in multiple sclerosis patients using robotics

Progressive multiple sclerosis, cognitive function, and quality of life

Contact Info

Product

Resources

About