Extremity Soft Tissue Sarcoma: Factors Predictive of Local Recurrence and Survival

Abstract

This study suggests that local control of extremity soft tissue sarcoma is improved by radical surgery and by the addition of radiotherapy when more conservative procedures are used. Overall survival appeared to be largely determined by patient (age, recurrent presentation) and tumour characteristics (grade, size).

Prognostic Index for Extremity Soft Tissue Sarcomas With Isolated Local Recurrence

“…44 Several studies have also shown that there is no difference in survival between patients who presented with primary sarcoma and those presenting initially with local recurrence. 38,45 The prognostic factors for distant metastases and survival in our study were tumor size, histologic grade, and time to local recurrence. Tumor size and histologic grade are the two most important prognostic factors for survival that have been consistently identified in primary soft tissue sarcomas.…”

Do Surgical Margin and Local Recurrence Influence Survival in Soft Tissue Sarcomas?

“…Negative surgical margin, low histologic grade, and use of radiotherapy are the most important factors in achieving local disease control [6,8,10,12,23,27,30,33]. However, the effect of positive margin and local recurrence as independent prognostic factors for metastasis-free survival and overall survival is still a matter of debate [9,10,16,21,23,25,28,29].…”

Fibro-histiocitoma maligno da pálpebra: relato de caso

“…Em outro estudo, margens cirúrgicas negativas associaram-se a menor taxa de recidiva e maior sobrevida (20) . Radioterapia adjuvante para o tratamento de tumores mesenquimais malignos parece estar relacionado com menor taxa de recidiva local ou metástases quando comparado ao tratamento cirúrgico isoladamente (20)(21) , especialmente em casos com margens cirúrgicas comprometidas (20) . O uso de quimioterapia adjuvante no tratamento de sarcomas de extremidades pode trazer beneficio com relação a sobrevida e taxa de recidiva (22)(23) , no entanto, a escassez de estudos não nos permite chegar a mesma conclusão com relação ao tratamento do fibro-histiocitoma maligno periocular.…”

“…Sugere-se, porém, um seguimento clínico e radiológico cuidadoso, com atenção especial aos pulmões e ao sistema nervoso central. Sinais de recidiva podem não ocorrer, mas não se deve descartar a possibilidade de exenteração orbitária, caso isto ocorra (9,21) . Até o momento, a biópsia excisional com remoção completa da lesão foi a conduta adotada no caso aqui descrito, levando-se em conta que a lesão era pequena e bem delimitada.…”